SIRT2 Protein, sirtuin 2

SIRT2

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SIRT2

Official Full Name sirtuin 2
Background This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Synonyms SIRT2; sirtuin 2; SIR2; SIR2L; SIR2L2; NAD-dependent protein deacetylase sirtuin-2; sirtuin-2; sirtuin type 2; SIR2-like protein 2; sir2-related protein type 2; silent information regulator 2; regulatory protein SIR2 homolog 2; NAD-dependent deacetylase sirtuin-2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SIRT2-23H Recombinant Human SIRT2 Protein, His-tagged E.coli His
    Human SIRT2-174H Recombinant Human SIRT2 protein, T7/His-tagged E.coli T7/His
    Human SIRT2-1834HCL Recombinant Human SIRT2 293 Cell Lysate HEK293 N/A
    Human SIRT2-191H Recombinant Human SIRT2 Protein, His-tagged E.coli His
    Human SIRT2-2680H Recombinant Human SIRT2, His-tagged E.coli His
    Human SIRT2-30564TH Recombinant Human SIRT2 E.coli N/A
    Human SIRT2-30566TH Recombinant Human SIRT2, His-tagged Insect Cell HIS
    Human SIRT2-30567TH Recombinant Human SIRT2, His-tagged E.coli His
    Human SIRT2-31405TH Recombinant Human SIRT2, His-tagged E.coli His
    Human SIRT2-463H Recombinant Human SIRT2, His-tagged E.coli His
    Human SIRT2-4875H Recombinant Human Sirtuin 2, His-tagged Sf9 Insect Cell His
    Human SIRT2-4876H Recombinant Human Sirtuin 2, GST-tagged E.coli GST
    Human SIRT2-647H Recombinant Human SIRT2 Protein, His-tagged E.coli His
    Human SIRT2-929H Recombinant Human SIRT2, His-tagged E.coli His
    Mouse SIRT2-15152M Recombinant Mouse SIRT2 Protein Mammalian Cell His
    Mouse Sirt2-648M Recombinant Mouse Sirt2 Protein, His-tagged E.coli His
    Rat SIRT2-5408R Recombinant Rat SIRT2 Protein Mammalian Cell His
    Rat Sirt2-649R Recombinant Rat Sirt2 Protein, His-tagged E.coli His
    Chicken SIRT2-2178C Recombinant Chicken SIRT2 Mammalian Cell His
    Zebrafish SIRT2-9999Z Recombinant Zebrafish SIRT2 Mammalian Cell His
    Kit-1083 SIRT2 Inhibitor Screening Assay Kit (Fluorometric) N/A
    Kit-2026 SIRT2 Direct Fluorescent Screening Assay Kit N/A

    SIRT2 involved in several pathways and played different roles in them. We selected most pathways SIRT2 participated on our site, such as Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class III, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling events mediated by HDAC Class I PRMT5; MXD1; FKBP3; SIRT4; TFCP2; WDR77; GATA1; SIRT7; NR2C1; GATA2
    Signaling events mediated by HDAC Class III SIRT7; SIRT2

    SIRT2 has several biochemical functions, for example, NOT NAD+ ADP-ribosyltransferase activity, NAD+ binding, NAD-dependent histone deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT2 itself. We selected most functions SIRT2 had, and list some proteins which have the same functions with SIRT2. You can find most of the proteins on our site.

    Function Related Protein
    NOT NAD+ ADP-ribosyltransferase activity SIRT5; SIRT1; SIRT2; SIRT3
    NAD+ binding SIRT7; GLUD1; SIRT4; SIRT1; SIRT6; HADH; UXS1; SIRT3; ALDH1A3; SIRT2
    NAD-dependent histone deacetylase activity SIRT1; SIRT2; SIRT6
    NOT NAD-dependent histone deacetylase activity SIRT2
    NAD-dependent histone deacetylase activity (H4-K16 specific) SIRT2
    NAD-dependent protein deacetylase activity SIRT1; SIRT2
    beta-tubulin binding PEX14; HDAC6; SNCA; PROL1; VAPB; IFT74; B4GALT1; OST4; PIFO; GABARAPL1
    chromatin binding HESX1; GATA2A; ZFP354B; BEND6; SIX1; PRKCBP1L; TCF7L2; CAMTA2; NAP1L2; BRD2
    histone acetyltransferase binding TP53; MYOCD; TAF7; PAX6; PCNA; SP1; TRIM68; EPAS1; ZBTB7A; HIF1A
    histone deacetylase activity HDAC5; MTA2; HDAC9; HDAC9B; NACC2; HDAC7; HDAC11; HDAC8; ATXN3L; HDAC10
    histone deacetylase binding FOXP3; YY1; WDTC1; CEBPB; PHB; NR2C1; HDAC5; CAMTA2; MAGEA1; NCOR2
    protein binding HIST1H4C; MRAP2; MRPL1; GATA1A; MCM8; NOL3; USP36; GNPDA2; RABGAP1; ARPIN
    protein deacetylase activity HDAC4; HDAC1; HDAC10; HDAC9; HDAC3; SIRT1; SIRT2; HDAC2; SIN3A; HDAC5
    transcription factor binding HES2; EP300; MED12L; NFIA; GTF2F1; NLK; FOXA3; HDAC5; CSNK2B; NBN
    tubulin deacetylase activity SIRT2; HDAC6
    NOT tubulin deacetylase activity SIRT2
    ubiquitin binding C36E6.2; NPLOC4; IDE; MARK4; SIRT2; FAF1; RNF31; C6orf106; TOP2A; SMAD3
    zinc ion binding MMP14A; TRIM26; RUNX1; SRSF7A; MTA1; GTF2H2C; TRIM2A; MSRB3; RNF213; PCGF2

    SIRT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT2.

    BUB1B; KAT2B; RELA; CDC14B; G6PD; RIPK3; MYOD1; HDAC6

    Yeung, F; Ramsey, CS; et al. Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylases. ONCOGENE 34:798-804(2015).
    Bajpe, PK; Prahallad, A; et al. A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. ONCOGENE 34:531-536(2015).

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