| Official Full Name | sirtuin 2 |
| Background | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010] |
| Synonyms | SIRT2; sirtuin 2; SIR2; SIR2L; SIR2L2; NAD-dependent protein deacetylase sirtuin-2; sirtuin-2; sirtuin type 2; SIR2-like protein 2; sir2-related protein type 2; silent information regulator 2; regulatory protein SIR2 homolog 2; NAD-dependent deacetylase sirtuin-2; |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
SIRT2 involved in several pathways and played different roles in them. We selected most pathways SIRT2 participated on our site, such as Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class III, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling events mediated by HDAC Class I | PRMT5; MXD1; FKBP3; SIRT4; TFCP2; WDR77; GATA1; SIRT7; NR2C1; GATA2 |
| Signaling events mediated by HDAC Class III | SIRT7; SIRT2 |
SIRT2 has several biochemical functions, for example, NOT NAD+ ADP-ribosyltransferase activity, NAD+ binding, NAD-dependent histone deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT2 itself. We selected most functions SIRT2 had, and list some proteins which have the same functions with SIRT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT NAD+ ADP-ribosyltransferase activity | SIRT5; SIRT1; SIRT2; SIRT3 |
| NAD+ binding | SIRT7; GLUD1; SIRT4; SIRT1; SIRT6; HADH; UXS1; SIRT3; ALDH1A3; SIRT2 |
| NAD-dependent histone deacetylase activity | SIRT1; SIRT2; SIRT6 |
| NOT NAD-dependent histone deacetylase activity | SIRT2 |
| NAD-dependent histone deacetylase activity (H4-K16 specific) | SIRT2 |
| NAD-dependent protein deacetylase activity | SIRT1; SIRT2 |
| beta-tubulin binding | PEX14; HDAC6; SNCA; PROL1; VAPB; IFT74; B4GALT1; OST4; PIFO; GABARAPL1 |
| chromatin binding | HESX1; GATA2A; ZFP354B; BEND6; SIX1; PRKCBP1L; TCF7L2; CAMTA2; NAP1L2; BRD2 |
| histone acetyltransferase binding | TP53; MYOCD; TAF7; PAX6; PCNA; SP1; TRIM68; EPAS1; ZBTB7A; HIF1A |
| histone deacetylase activity | HDAC5; MTA2; HDAC9; HDAC9B; NACC2; HDAC7; HDAC11; HDAC8; ATXN3L; HDAC10 |
| histone deacetylase binding | FOXP3; YY1; WDTC1; CEBPB; PHB; NR2C1; HDAC5; CAMTA2; MAGEA1; NCOR2 |
| protein binding | HIST1H4C; MRAP2; MRPL1; GATA1A; MCM8; NOL3; USP36; GNPDA2; RABGAP1; ARPIN |
| protein deacetylase activity | HDAC4; HDAC1; HDAC10; HDAC9; HDAC3; SIRT1; SIRT2; HDAC2; SIN3A; HDAC5 |
| transcription factor binding | HES2; EP300; MED12L; NFIA; GTF2F1; NLK; FOXA3; HDAC5; CSNK2B; NBN |
| tubulin deacetylase activity | SIRT2; HDAC6 |
| NOT tubulin deacetylase activity | SIRT2 |
| ubiquitin binding | C36E6.2; NPLOC4; IDE; MARK4; SIRT2; FAF1; RNF31; C6orf106; TOP2A; SMAD3 |
| zinc ion binding | MMP14A; TRIM26; RUNX1; SRSF7A; MTA1; GTF2H2C; TRIM2A; MSRB3; RNF213; PCGF2 |
SIRT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT2.
BUB1B; KAT2B; RELA; CDC14B; G6PD; RIPK3; MYOD1; HDAC6
Easy access to products and services you need from our library via powerful searching tools.
Copyright © 2007 – 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy
