Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

SIRT2

  • Official Full Name

    sirtuin 2

  • Overview

    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
  • Synonyms

    SIRT2; sirtuin 2; SIR2; SIR2L; SIR2L2; NAD-dependent protein deacetylase sirtuin-2; sirtuin-2; sirtuin type 2; SIR2-like protein 2; sir2-related protein type 2; silent information regulator 2; regulatory protein SIR2 homolog 2; NAD-dependent deacetylase sirtuin-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • C
  • 6×His
  • GST
  • His
  • HIS
  • His (Fc)
  • Avi
  • N/A
  • N
  • T7|His
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SIRT2-30567TH Recombinant Human SIRT2, His-tagged E.coli His
Human SIRT2-30564TH Recombinant Human SIRT2 E.coli N/A 389 amino acids
Human SIRT2-463H Recombinant Human SIRT2, His-tagged E.coli His
Human SIRT2-30566TH Recombinant Human SIRT2, His-tagged Insect Cell HIS 351 amino acids
Human SIRT2-31405TH Active Recombinant Human SIRT2 Protein (50-356), C-6xHis tagged E.coli C-6×His 50-356
Human SIRT2-4876H Recombinant Human Sirtuin 2, GST-tagged E.coli GST
Human SIRT2-191H Recombinant Human SIRT2 Protein, His-tagged E.coli His 50-389
Human SIRT2-929H Recombinant Human SIRT2, His-tagged E.coli His
Human SIRT2-2680H Recombinant Human SIRT2, His-tagged E.coli His 1-352aa
Human SIRT2-4875H Recombinant Human Sirtuin 2, His-tagged Sf9 Insect Cell His
Human SIRT2-174H Recombinant Human SIRT2 protein, T7/His-tagged E.coli T7/His
Human SIRT2-647H Recombinant Human SIRT2 Protein, His-tagged E.coli His Glu65~Glu340
Human SIRT2-1834HCL Recombinant Human SIRT2 293 Cell Lysate HEK293 N/A
Human SIRT2-5758H Recombinant Human SIRT2 Protein E.coli Tag Free
Human SIRT2-23H Recombinant Human SIRT2 Protein, His-tagged E.coli His 2-389
Human SIRT2-5759H Recombinant Human SIRT2 Protein (Met1-Gln389), N-GST tagged E.coli N-GST Met1-Gln389
Human SIRT2-107H Recombinant Human SIRT2 Protein, His-tagged E. coli His 2-389
Mouse Sirt2-648M Recombinant Mouse Sirt2 Protein, His-tagged E.coli His Glu65~Glu340
Mouse SIRT2-15152M Recombinant Mouse SIRT2 Protein Mammalian Cell His
Mouse SIRT2-8181M Recombinant Mouse SIRT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SIRT2-8181M-B Recombinant Mouse SIRT2 Protein Pre-coupled Magnetic Beads HEK293
Rat SIRT2-5408R Recombinant Rat SIRT2 Protein Mammalian Cell His
Rat Sirt2-649R Recombinant Rat Sirt2 Protein, His-tagged E.coli His Glu28~Leu303
Rat SIRT2-5067R Recombinant Rat SIRT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SIRT2-5067R-B Recombinant Rat SIRT2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SIRT2-9999Z Recombinant Zebrafish SIRT2 Mammalian Cell His
Chicken SIRT2-2178C Recombinant Chicken SIRT2 Mammalian Cell His
Kit-1083 SIRT2 Inhibitor Screening Assay Kit (Fluorometric) N/A
Kit-2026 SIRT2 Direct Fluorescent Screening Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SIRT2 Related Articles
  • SIRT2 Related Research Area

SIRT2 involved in several pathways and played different roles in them. We selected most pathways SIRT2 participated on our site, such as Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class III, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling events mediated by HDAC Class INR2C1;SIRT5;SIRT2;GATA2;PRMT5;SIRT4;TFCP2;SIRT7;MXD1
Signaling events mediated by HDAC Class IIISIRT2;SIRT7

SIRT2 has several biochemical functions, for example, NOT NAD+ ADP-ribosyltransferase activity, NAD+ binding, NAD-dependent histone deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT2 itself. We selected most functions SIRT2 had, and list some proteins which have the same functions with SIRT2. You can find most of the proteins on our site.

Function Related Protein
NOT NAD+ ADP-ribosyltransferase activitySIRT5;SIRT3;SIRT1;SIRT2
NAD+ bindingSIRT7;SIRT1;ALDH1A3;SIRT6;UXS1;SIRT4;SIRT2;SIRT5;GLUD1
NAD-dependent histone deacetylase activitySIRT2;SIRT1;SIRT6
NOT NAD-dependent histone deacetylase activity
NAD-dependent histone deacetylase activity (H4-K16 specific)
NAD-dependent protein deacetylase activitySIRT1;SIRT2
beta-tubulin bindingPDCD5;RANBP10;ARL8A;B4GALT1;PACRG;IFT74;SIRT2;GABARAPL2;BBS4
chromatin bindingSMC1A;SOX9A;ADNP;MECP2;CREB3L1;POLG;ZNF143;HMGXB4;ZFP143
histone acetyltransferase bindingSP1;TAF7L;CITED2;MYOCD;EPAS1;NR4A3;CEBPB;ETS1;TP53
histone deacetylase activityHDAC9B;SIRT1;HDAC7;HDAC2;HDAC4;HDAC1;HDAC11;HDAC5;NACC2
histone deacetylase bindingZNF703;BRMS1;TOP2A;NRIP1;MEF2B;HIC1;NACC2;RFXANK;SIX3
protein bindingCETN3;KRT6C;PTPRN;MUTYH;TMEM147;DACH1;AIDA;POLG;COL1A1
protein deacetylase activityHDAC9;HDAC1;HDAC2;SIRT2;HDAC4;HDAC10;SIN3A;SIRT1;HDAC3
transcription factor bindingDAXX;RBPJ;NKX3;PIANP;HIF1A;BPTF;SOX8;MED12L;RNF19A
tubulin deacetylase activityHDAC6;SIRT2
NOT tubulin deacetylase activity
ubiquitin bindingUBXN1;UBXN2B;C6orf106;D17WSU92E;USP13;CRY2;CRY1;AUP1;RNF31
zinc ion bindingTIMM9;GALT;RNF166;ADAMTS4;PEX2;ADAMTS15A;TIMM13;NR5A1B;TRAIP

SIRT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT2.

BUB1B; KAT2B; RELA; CDC14B; G6PD; RIPK3; MYOD1; HDAC6

Yeung, F; Ramsey, CS; et al. Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylases. ONCOGENE 34:798-804(2015).
Bajpe, PK; Prahallad, A; et al. A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. ONCOGENE 34:531-536(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does SIRT2 participate in the regulation of cellular stress responses? 02/09/2022

SIRT2 is involved in stress response pathways, deacetylating and modulating the activity of stress-responsive proteins, contributing to cellular adaptation to various stress conditions.

How does SIRT2 contribute to the regulation of cellular metabolism? 07/15/2021

SIRT2 influences cellular metabolism by deacetylating enzymes involved in glycolysis, fatty acid metabolism, and mitochondrial function, impacting overall energy homeostasis.

Explain the molecular mechanisms underlying SIRT2-mediated deacetylation of target proteins. 11/30/2020

SIRT2 uses NAD+ as a cofactor to remove acetyl groups from lysine residues, a process that links cellular metabolic state to protein acetylation and deacetylation.

Discuss the role of SIRT2 in the regulation of cell cycle progression. 08/19/2019

SIRT2 influences cell cycle progression by deacetylating key regulators, such as cyclin-dependent kinases (CDKs) and checkpoint proteins, impacting cell cycle checkpoints and progression.

Discuss the role of SIRT2 in neurodegenerative diseases and its potential as a therapeutic target. 01/04/2018

SIRT2 has been implicated in neurodegenerative diseases, and modulating its activity is explored as a potential therapeutic strategy for conditions such as Parkinson's disease.

Customer Reviews (3)

Write a review
Reviews
04/15/2021

    Efficient and knowledgeable customer service—made our purchase straightforward.

    11/02/2020

      This recombined protein is our go-to for dependable and accurate results.

      08/30/2018

        Punctual delivery is crucial, and this product arrived right on time.

        Ask a Question for All SIRT2 Products

        Required fields are marked with *

        My Review for All SIRT2 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends