smad6
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  • Official Full Name
  • SMAD family member 6
  • Background
  • The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]
  • Synonyms
  • SMAD6; SMAD family member 6; AOVD2; MADH6; MADH7; HsT17432; mothers against decapentaplegic homolog 6; SMAD 6; hSMAD6; MAD homolog 6; mothers against DPP homolog 6; SMAD, mothers against DPP homolog 6; Mothers against decapentaplegic, drosophila, homolog of, 6;
Cat.#:PGC-299HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD6 Protein, His-tagged
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Cat.#:SMAD6-1913HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMAD6 Protein, MYC/DDK-tagged
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Cat.#:SMAD6-22HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human SMAD6 Protein, GST-tagged
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Cat.#:Smad6-300MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Smad6 Protein, His-tagged
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Cat.#:Smad6-301RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Smad6 Protein, His-tagged
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Cat.#:SMAD6-2801HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD6, His-tagged
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Cat.#:SMAD6-15589MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD6 Protein
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Cat.#:SMAD6-5821CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SMAD6
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Cat.#:SMAD6-4113ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SMAD6
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Cat.#:SMAD6-1644HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SMAD6 cell lysate
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Involved Pathway

SMAD6 involved in several pathways and played different roles in them. We selected most pathways SMAD6 participated on our site, such as TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TGF-beta signaling pathway
SMURF1; BMPR2; BMP6; PPP2R1B; TGFB2; TGFB1; TGFBR2; INHBA; AMHR2; BMPR1BB

Protein Function

SMAD6 has several biochemical functions, for example, I-SMAD binding, R-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD6 itself. We selected most functions SMAD6 had, and list some proteins which have the same functions with SMAD6. You can find most of the proteins on our site.
Function
Related Protein
Function I-SMAD binding
Related Protein SMAD4; SMAD6; SMAD2; SMURF1; SMAD1; CTNNB1; TGFB1I1; TGFBR1; AXIN1; AXIN2
Function R-SMAD binding
Related Protein JUN; TRIM33; C18orf1; SMAD6; ANKRD1; PMEPA1; ZEB2; SMURF1; SMAD2; PAX6
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein NR6A1; GATA1; ZKSCAN3; JDP2; HNRNPK; TTC6; PITX2; NR1D1; ZNF502; SIX2
Function chromatin binding
Related Protein GABPA; TOX; MSH6; CEBPB; ANKRD17; MCM5; MKRN1; TOX2; STAT5B; JMJD5
Function co-SMAD binding
Related Protein SMAD3; SMAD2; TGIF1; USP9X; SMAD1; SMAD6; TRIM33; CITED1; GATA4; FOXH1
Function identical protein binding
Related Protein CNTN2; AKT1; NDC80; SQSTM1; CBLL1; Serpina1b; PCBD1; HACL1; TYSND1; KDM6A
Function metal ion binding
Related Protein BTK; PVALB1; RSAD1; SOBPA; RAB11FIP4; NUAK1; ZFP110; HDAC8; KDM2AA; ZNF572
Function protein binding
Related Protein BNIPL; PALM; AKT1; FUCA2; IRF3; SULT2A1; ASCL1; RG9MTD1; DCTN4; SURF1
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZFP184; RBPJA; DBPB; HOXB7; NR2F2; SCAND1; NR5A1A; GATAD2B; RCAN1; RUNX2
Function transcription regulatory region DNA binding
Related Protein CTCF; ZFHX3; ETV5; ZNF613; CREB3L1; HNRNPL; ZFP746; MTERFD1; SNCA; TP53
Function transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
Related Protein SMAD6; SMAD7
Function type I activin receptor binding
Related Protein SPAW; NDR2; NODAL; SMAD6; NDR1
Function type I transforming growth factor beta receptor binding
Related Protein TGFBR2; FKBP1A; SMAD6; TGFB1; SMAD2; SMAD7; ENG; SNX25; TGFB3
Function ubiquitin protein ligase binding
Related Protein PER3; PTPN22; DNAJA1; CUL1B; CHEK2; WFS1; HSPA8; RALB; GRIK2; HSPA1B

Interacting Protein

SMAD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD6.
PRKX; SMAD1; Runx2; RUNX2; UBE2O; RPS6KA5; FKBP1A; MAPK6; SMURF2

SMAD6 Related Articles

Islam, SS; Mokhtari, RB; et al. Spatio-Temporal Distribution of Smads and Role of Smads/TGF-beta/BMP-4 in the Regulation of Mouse Bladder Organogenesis. PLOS ONE 8:-(2013).
Kaneda, A; Fujita, T; et al. Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence. PLOS GENETICS 7:-(2011).