smad7
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  • Official Full Name
  • SMAD family member 7
  • Background
  • The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • SMAD7; SMAD family member 7; MAD, mothers against decapentaplegic homolog 7 (Drosophila) , MADH7, MADH8, SMAD, mothers against DPP homolog 7 (Drosophila); mothers against decapentaplegic homolog 7; hSMAD7; MAD homolog 8; mothers against DPP homolog 8; SM
Cat.#:SMAD7-1912HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMAD7 Protein, MYC/DDK-tagged
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Cat.#:SMAD7-29105THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SMAD7
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Cat.#:SMAD7-5610RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SMAD7 Protein
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Cat.#:SMAD7-9566ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SMAD7
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Involved Pathway

SMAD7 involved in several pathways and played different roles in them. We selected most pathways SMAD7 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TGF-beta signaling pathway
BMP2; TGFB3; PPP2CA; EP300; ID2A; BMPR2; TGFB2; SMAD5; ROCK2B; RPS6KB1B
Hippo signaling pathway
BMP8B; DLG3; AREG; ID2; TEAD4; SMAD4; PPP2R1A; INADL; BMP8A; FZD6

Protein Function

SMAD7 has several biochemical functions, for example, I-SMAD binding, activin binding, beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD7 itself. We selected most functions SMAD7 had, and list some proteins which have the same functions with SMAD7. You can find most of the proteins on our site.
Function
Related Protein
Function I-SMAD binding
Related Protein SMAD4; SMAD1; AXIN1; TGFB1I1; SMAD6; CTNNB1; SMAD7; AXIN2; TGFBR1; SMAD2
Function activin binding
Related Protein FST; SMURF1; FKBP1A; ACVR1; FSTL3; TGFBR3; SMAD7; ACVR2B; ACVRL1; ENG
Function beta-catenin binding
Related Protein BCL9L; BTRC; SLC9A3R1; CDH5; DACT3; CALCOCO1; LZIC; LEF1; CDH1; PTPRU
Function collagen binding
Related Protein ACHE; PODN; VWF; USH2A; PCOLCE; ITGA2; HSD17B12; GP6; MMP9; NID2
Function metal ion binding
Related Protein ZNF43; RNF169; ZFP354B; ZNF10; KLF18; KSR1; INPP5B; PDP2; DMRTA2; EXT1B
Function protein binding
Related Protein AMBRA1; PLCB1; HMGA1; HILPDA; AKR1B10; MXD3; ARNT; ZUFSP; SNAI2; LEPROT
Function transcription factor activity, sequence-specific DNA binding
Related Protein RFXAP; KLF5; SIM1A; TRP63; FOXN1; CBFB; POU6F1; ZBTB14; FLI1B; RUNX3
Function transcription regulatory region DNA binding
Related Protein ZFP821; ZNF613; HINFP; FOXA1; SREBF1; NR1H3; HDAC1; BRCA1; HNF1A; TAF2
Function transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
Related Protein SMAD7; SMAD6
Function type I transforming growth factor beta receptor binding
Related Protein SMAD2; SMAD6; SMAD7; SNX25; TGFBR2; TGFB1; ENG; FKBP1A; TGFB3
Function ubiquitin protein ligase binding
Related Protein RNF31; RNF20; PTPN22; ATXN3; SMAD3; BLZF1; RNF40; MOAP1; RB1; CXCR4

Interacting Protein

SMAD7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD7.
COPS5; WWP2; FKBP1A; AXIN1

SMAD7 Related Articles

Amiot, A; Peyrin-Biroulet, L; et al. Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases. THERAPEUTIC ADVANCES IN GASTROENTEROLOGY 8:66-82(2015).
Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).

SMAD7 Related Gene Family

TGF