Recombinant Human SMAD7 Protein, MYC/DDK-tagged

• Cat.No.: SMAD7-1912H
• Product Overview: Recombinant human SMAD7 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 46.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: SMAD7 SMAD family member 7 [ Homo sapiens ]
• Official Symbol: SMAD7
• Synonyms: CRCS3; MADH7; MADH8
• Gene ID: 4092
• mRNA Refseq: NM_001190821
• Protein Refseq: NP_001177750
• MIM: 602932
• UniProt ID: O15105