SOD1

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SOD1

Official Full Name superoxide dismutase 1, soluble
Background The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
Synonyms SOD1; superoxide dismutase 1, soluble; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer; superoxide dismutase [Cu-Zn]; SOD, soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; epididymis secretory protein Li 44;
    • Species :
    • Bovine
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Horse
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Sheep
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Rabbit
    • yeast
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • MBP
    • SUMO
    • Myc
    • T7
    • Myc/DDK
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SOD1-070H Recombinant Human SOD1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse Sod1-6040M Recombinant Mouse Sod1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human SOD1-67H Recombinant Human SOD1 Protein Insect Cell
    Human CAB11605RH Rabbit Monoclonal Antibody to Human Superoxide Dismutase 1, Soluble Rabbit N/A
    Human SOD1-04H Recombinant Human SOD1 protein E.coli N/A
    Human SOD1-05H Recombinant Human SOD1 protein E.coli N/A
    Human SOD1-1037H Recombinant Human SOD1 Protein E.coli N/A
    Human SOD1-103H Recombinant Human SOD1, low endotoxin E.coli N/A
    Human SOD1-104H Recombinant Human SOD1 E.coli N/A
    Human SOD1-1158H Recombinant Human SOD1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SOD1-1161H Recombinant Human SOD1 protein, His-tagged E.coli His
    Human SOD1-1432H Recombinant Human SOD1 E.coli N/A
    Human SOD1-1570H Recombinant Human SOD1 protein E.coli N/A
    Human SOD1-1576HCL Recombinant Human SOD1 293 Cell Lysate HEK293 N/A
    Human SOD1-1635H Recombinant Human Superoxide Dismutase 1, Soluble, GST-tagged E.coli GST
    Human SOD1-170H Recombinant Human SOD1 Protein, His-tagged E.coli His
    Human SOD1-200H Recombinant Human Superoxide Dismutase 1 E.coli N/A
    Human SOD1-30341TH Recombinant Human SOD1 E.coli N/A
    Human SOD1-326H Recombinant Human Superoxide Dismutase 1, Soluble, His-tagged E.coli His
    Human SOD1-328H Recombinant Human SOD1 protein, His/MBP-tagged E.coli His/MBP
    Human SOD1-642H Recombinant Human SOD1 protein, His-tagged E.coli His
    Human SOD1-6992H Recombinant Human SOD1, GST-tagged E.coli GST
    Human SOD1-8H Recombinant Human Superoxide Dismutase yeast N/A
    Mouse SOD1-15749M Recombinant Mouse SOD1 Protein Mammalian Cell His
    Mouse Sod1-2023M Recombinant Mouse Sod1 protein, His-tagged E.coli His
    Rat Sod1-2026R Recombinant Rat Sod1 protein, His-tagged E.coli His
    Rat SOD1-5666R Recombinant Rat SOD1 Protein Mammalian Cell His
    Cynomolgus Monkey SOD1-956C Recombinant Cynomolgus SOD1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque SOD1-4405R Recombinant Rhesus monkey SOD1 Protein, His-tagged Mammalian Cell His
    Bovine SOD1-101B Native Bovine SOD N/A
    Bovine SOD1-102B Native Bovine SOD, modified N/A
    Chicken SOD1-2022C Recombinant Chicken SOD1 protein, His & T7-tagged E.coli His/T7
    Rabbit SOD1-2027R Recombinant Rabbit SOD1 protein, His-tagged E.coli His
    Chicken SOD1-6621C Recombinant Chicken SOD1 Mammalian Cell His
    Zebrafish sod1-1373Z Recombinant Zebrafish sod1 Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
    Zebrafish SOD1-8884Z Recombinant Zebrafish SOD1 Mammalian Cell His
    Cattle SOD1-2020C Recombinant Cattle SOD1 protein, His-tagged E.coli His
    Horse SOD1-2021H Recombinant Horse SOD1 protein, His & T7-tagged E.coli His/T7
    Sheep SOD1-2024S Recombinant Sheep SOD1 protein, His & T7-tagged E.coli His/T7
    Pig SOD1-2025P Recombinant Pig SOD1 protein, His & T7-tagged E.coli His/T7

    SOD1 involved in several pathways and played different roles in them. We selected most pathways SOD1 participated on our site, such as Peroxisome, Amyotrophic lateral sclerosis (ALS), Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Peroxisome PXMP2; PEX7; ACAA1; PEX11C; HMGCL; PECR; MPV17L2; SOD1; PEX13; ACSL5
    Amyotrophic lateral sclerosis (ALS) SOD1; NEFM; APAF1; MAPK11; TNFRSF1B; DERL1; PPP3CB; PPP3CC; PRPH; BCL2
    Huntingtons disease NDUFS4; NDUFB5; ATP5E; NDUFB11; UQCRC1; DCTN1; ATP5C1; NDUFA7; NDUFA11; UQCR11
    Prion diseases C9; BAX; NCAM2; FYN; IL1B; NCAM1; C8A; Hc; C1QB; SOD1

    SOD1 has several biochemical functions, for example, Rac GTPase binding, chaperone binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOD1 itself. We selected most functions SOD1 had, and list some proteins which have the same functions with SOD1. You can find most of the proteins on our site.

    Function Related Protein
    Rac GTPase binding RAB7; NOX1; CAV1; SRGAP3; HACE1; DOCK7; PAK6; ARHGAP4A; PAK3; PAK2
    chaperone binding SLC25A17; AMFR; HYOU1; HSPA5; BAG5; AHSA1L; TIMM44; ATP1A2; ST13; DNAJB2
    copper ion binding P2RX2; HAMP; METTL17; TYRP1B; P2RX4; SERPINB1A; CCS; ADNP; APOA4; TYR
    identical protein binding FKBP8; PFKM; CEP57L1; RIPK3; PAK2; MNS1; ALK; FNBP1; NISCH; PRKAB2
    protein binding SYNCRIP; BCLAF1; SRPK2; TBL3; TEKT5; PRMT3; ZNF259; ZBTB44; DCTN4; ITSN1
    protein homodimerization activity ZHX2; ASNS; DMRTC2; PAFAH1B2; MUC13; PRTFDC1; GREM2; CUBN; CCDC103; SYNDIG1
    protein phosphatase 2B binding AKAP5; PPP3CB; AKAP1; BAD; SLC9A1; ATP2B4; SOD1; MYOZ2
    superoxide dismutase activity NQO1; SOD3A; SOD2; SOD1; PRNPA; CCS
    zinc ion binding KLF4; TRIM25; TRIM14; NR2F2; RFPL2; ZFAND5; ADAMTS3; RABGGTB; LMO7; NANOS3

    SOD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOD1.

    Chga; Chgb; DYNC2LI1; RAC1; BAG3

    Malaspina, A; Puentes, F; et al. Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective. INTERNATIONAL IMMUNOLOGY 27:117-129(2015).
    Xu, GL; Ayers, JI; et al. Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice. HUMAN MOLECULAR GENETICS 24:1019-1035(2015).

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