|Official Full Name||superoxide dismutase 1, soluble|
|Background||The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]|
|Synonyms||SOD1; superoxide dismutase 1, soluble; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer; superoxide dismutase [Cu-Zn]; SOD, soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; epididymis secretory protein Li 44;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
SOD1 involved in several pathways and played different roles in them. We selected most pathways SOD1 participated on our site, such as Peroxisome, Amyotrophic lateral sclerosis (ALS), Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Peroxisome||PXMP2; PEX7; ACAA1; PEX11C; HMGCL; PECR; MPV17L2; SOD1; PEX13; ACSL5|
|Amyotrophic lateral sclerosis (ALS)||SOD1; NEFM; APAF1; MAPK11; TNFRSF1B; DERL1; PPP3CB; PPP3CC; PRPH; BCL2|
|Huntingtons disease||NDUFS4; NDUFB5; ATP5E; NDUFB11; UQCRC1; DCTN1; ATP5C1; NDUFA7; NDUFA11; UQCR11|
|Prion diseases||C9; BAX; NCAM2; FYN; IL1B; NCAM1; C8A; Hc; C1QB; SOD1|
SOD1 has several biochemical functions, for example, Rac GTPase binding, chaperone binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOD1 itself. We selected most functions SOD1 had, and list some proteins which have the same functions with SOD1. You can find most of the proteins on our site.
|Rac GTPase binding||RAB7; NOX1; CAV1; SRGAP3; HACE1; DOCK7; PAK6; ARHGAP4A; PAK3; PAK2|
|chaperone binding||SLC25A17; AMFR; HYOU1; HSPA5; BAG5; AHSA1L; TIMM44; ATP1A2; ST13; DNAJB2|
|copper ion binding||P2RX2; HAMP; METTL17; TYRP1B; P2RX4; SERPINB1A; CCS; ADNP; APOA4; TYR|
|identical protein binding||FKBP8; PFKM; CEP57L1; RIPK3; PAK2; MNS1; ALK; FNBP1; NISCH; PRKAB2|
|protein binding||SYNCRIP; BCLAF1; SRPK2; TBL3; TEKT5; PRMT3; ZNF259; ZBTB44; DCTN4; ITSN1|
|protein homodimerization activity||ZHX2; ASNS; DMRTC2; PAFAH1B2; MUC13; PRTFDC1; GREM2; CUBN; CCDC103; SYNDIG1|
|protein phosphatase 2B binding||AKAP5; PPP3CB; AKAP1; BAD; SLC9A1; ATP2B4; SOD1; MYOZ2|
|superoxide dismutase activity||NQO1; SOD3A; SOD2; SOD1; PRNPA; CCS|
|zinc ion binding||KLF4; TRIM25; TRIM14; NR2F2; RFPL2; ZFAND5; ADAMTS3; RABGGTB; LMO7; NANOS3|
SOD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOD1.
Chga; Chgb; DYNC2LI1; RAC1; BAG3