Recombinant Full Length Human SOD1 Protein, C-Flag-tagged

• Cat.No.: SOD1-1180HFL
• Product Overview: Recombinant Full Length Human SOD1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 15.8 kDa
• AA Sequence: MATKAVCVLKGDGPVQGIINFEQKE SNGPVKVWGSIKGLTEGLHGFHVHE FGDNTAGCTSAGPHFNPLSR KHGGPKDEERHVGDLGNVTADKDGV ADVSIEDSVISLSGDHCIIGRTLVV HEKADDLGKGGNEESTKTGN
  AGSRLACGVIGIAQTRTRPLEQKLI SEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Huntington's disease, Prion diseases

Gene Information

• Gene Name: SOD1 superoxide dismutase 1 [ Homo sapiens (human) ]
• Official Symbol: SOD1
• Synonyms: ALS; SOD; ALS1; IPOA; STAHP; hSod1; HEL-S-44; homodimer
• Gene ID: 6647
• mRNA Refseq: NM_000454.5
• Protein Refseq: NP_000445.1
• MIM: 147450
• UniProt ID: P00441