tlr1
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  • Official Full Name
  • toll-like receptor 1
  • Background
  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.
  • Synonyms
  • TLR1; toll-like receptor 1; TIL; CD281; rsc786; KIAA0012; MGC104956; MGC126311; MGC126312; TIL. LPRS5; DKFZp547I0610; DKFZp564I0682; OTTHUMP00000218158; OTTHUMP00000218173; OTTHUMP00000218175; toll/interleukin-1 receptor-like protein; Similar to Drosophila Toll protein; Toll (Drosophila) homolog; Toll like receptor 1; Toll like receptor 1 Precursor; Toll/Interleukin 1 receptor like
Cat.#:TLR1-1815HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human TLR1 Protein (25-580 aa), His-tagged
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Cat.#:TLR1-685HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human TLR1, Fc Chimera
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Cat.#:TLR1-2069HTag:His|S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR1 protein, His & S-tagged
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Cat.#:TLR1-2393HTag:Fc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Toll-like Receptor 1, Fc Chimera
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Cat.#:TLR1-3257HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR1, GST-tagged
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Cat.#:TLR1-686HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human TLR1, Fc-tagged
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Cat.#:TLR1-705HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TLR1, Fc-tagged, Biotinylated
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Cat.#:TLR1-706HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TLR1, Fc-tagged
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Cat.#:Tlr1-2070MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tlr1 protein, His & GST-tagged
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Cat.#:TLR1-1664RTag:N/A
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR1 Protein
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Cat.#:TLR1-1665RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR1 Protein, hIgG1-tagged
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Cat.#:TLR1-1666RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR1 Protein, hIgG4-tagged
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Cat.#:TLR1-4729RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TLR1 Protein, His-tagged
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Cat.#:TLR1-7077ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TLR1
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Cat.#:TLR1-1047HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TLR1 293 Cell Lysate
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Involved Pathway

TLR1 involved in several pathways and played different roles in them. We selected most pathways TLR1 participated on our site, such as Toll-like receptor signaling pathway, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Toll-like receptor signaling pathway
TLR4BA; IFNB1; AKT2L; MAP2K6; MAPK12A; MAPK10; CD86; MAP2K7; IFNA5; PIK3R1
Tuberculosis
PPP3CC; ATP6V1H; SRC; CD74; AKT1; EEA1; FCGR3A; SPHK2; MAPK8; ATP6V0B

Protein Function

TLR1 has several biochemical functions, for example, Toll-like receptor 2 binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR1 itself. We selected most functions TLR1 had, and list some proteins which have the same functions with TLR1. You can find most of the proteins on our site.
Function
Related Protein
Function Toll-like receptor 2 binding
Related Protein TIRAP; TLR6; TLR1
Function protein binding
Related Protein COL4A3; ANKS4B; PSMB8; SNCA; PICALM; COG3; NTS; KPNA2; YWHAZ; TERT
Function protein heterodimerization activity
Related Protein HYPM; GCA; HIST1H2AM; MYOD1; MAFA; TAF11; BOKA; PAFAH1B3; ADIPOR2; LIMK1
Function receptor activity
Related Protein ABP1; CADM1; ANTXR2A; TNFRSF17; ITGB1B; ITGB8; PVRL4; CD33; P2RY2; GRIA4B
Function transmembrane signaling receptor activity
Related Protein OR4C13; TRPV1; LILRB5; GHRHRL; Cd79a, Cd79b; CLDN3; CALCRLA; NRXN1; IL11RA; GHRHRA

Interacting Protein

TLR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR1.
s-[2,3-bis(palmitoyloxy)propyl]-cys-ser-lys-lys-lys-lys

TLR1 Related Articles

Ammerdorffer, A; Schoffelen, T; et al. Recognition of Coxiella burnetii by Toll-like Receptors and Nucleotide-Binding Oligomerization Domain-like Receptors. JOURNAL OF INFECTIOUS DISEASES 211:978-987(2015).
Zhang, XJ; Xu, J; et al. Expression and function of Toll-like receptors in peripheral blood mononuclear cells from patients with ovarian cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:275-286(2015).