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TRPV1

  • Official Full Name

    transient receptor potential cation channel, subfamily V, member 1

  • Overview

    The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It was the first isolated member of the transient receptor potential vanilloid receptor proteins which in turn are a sub family of the transient receptor potential protein group. This protein is a member of the TRPV group of transient receptor potential family of ion channels.
  • Synonyms

    Trpv1; transient receptor potential cation channel, subfamily V, member 1; Vr1; Vr1l1; VR.5"sv; transient receptor potential cation channel subfamily V member 1; OTRPC1; capsaicin receptor; vanilloid receptor 1;; osm-9-like TRP channel 1; vanilloid type 1 receptor; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Flag
  • TRxA
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRPV1-734HCL Recombinant Human TRPV1 293 Cell Lysate HEK293 N/A
Human TRPV1-735HCL Recombinant Human TRPV1 293 Cell Lysate HEK293 N/A
Human TRPV1-0944H Recombinant Human TRPV1 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human TRPV1-345H Recombinant Human TRPV1 Protein, His-tagged E.coli His Met1~Glu153
Human TRPV1-346H Recombinant Human TRPV1 protein, His-tagged E. coli His 1-203 aa
Human TRPV1-1174HFL Recombinant Human TRPV1 protein, His&Flag-tagged HEK293 His&Flag 1-839 aa
Mouse TRPV1-17461M Recombinant Mouse TRPV1 Protein Mammalian Cell His
Mouse TRPV1-347M Recombinant Mouse TRPV1 Protein, His&TRxA-tagged E.coli His&TRxA Met1~Arg433
Mouse TRPV1-9659M-B Recombinant Mouse TRPV1 Protein Pre-coupled Magnetic Beads HEK293
Mouse TRPV1-9659M Recombinant Mouse TRPV1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TRPV1-6303R Recombinant Rat TRPV1 Protein Mammalian Cell His
Rat TRPV1-5960R-B Recombinant Rat TRPV1 Protein Pre-coupled Magnetic Beads HEK293
Rat TRPV1-5960R Recombinant Rat TRPV1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish TRPV1-6716Z Recombinant Zebrafish TRPV1 Mammalian Cell His
Chicken TRPV1-6141C Recombinant Chicken TRPV1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRPV1 Related Articles
  • TRPV1 Related Research Area

TRPV1 involved in several pathways and played different roles in them. We selected most pathways TRPV1 participated on our site, such as Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPV1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionRXFP3;HTR2CL1;THRB;TAAR12G;S1PR5A;GLRA3;GIPR;TAAR14H;GLRBB
Inflammatory mediator regulation of TRP channelsCYP2C54;GNAQ;IGF1;PIK3R1;PLCG1;CALML5;CALM2;IL1B;KLK1B4

TRPV1 has several biochemical functions, for example, ATP binding, calcium channel activity, calcium-release channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPV1 itself. We selected most functions TRPV1 had, and list some proteins which have the same functions with TRPV1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDCLK3;MCM8;UBE2N;FARS2;PRKACAA;UBE2E2;EK1;ASS1;AK7A
calcium channel activityCACNA1SA;CACNG7A;TRPC2B;AKR1C1;TRPC4A;PANX1;TMEM37;CACNG2A;TRPM2
calcium-release channel activityRYR2;JPH2;RYR3;RYR1;RASA3;JPH3;TRPV1
calmodulin bindingCAMK1G;RGS16;MYO7A;MAP2;EPB41B;MARCKSB;PHKA1;MARCKSA;NDUFAF4
excitatory extracellular ligand-gated ion channel activity
phosphoprotein bindingPKD2;SRC;ARR3;CBX4;PIH1D1;FKBP4;APTX;RRAGA;SNCA
transmembrane signaling receptor activityLGR5;CLEC1B;LEPR;NRXN1;CD3D;TNFRSF10C;CD79A;NRXN2;BAI2

TRPV1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPV1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPV1.

Solorzano, C; Villafuerte, D; et al. Primary Afferent and Spinal Cord Expression of Gastrin-Releasing Peptide: Message, Protein, and Antibody Concerns. JOURNAL OF NEUROSCIENCE 35:648-657(2015).
Ruan, Z; Wang, HM; et al. A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects. JOURNAL OF NEUROCHEMISTRY 133:93-103(2015).
  • Q&As
  • Reviews

Q&As (6)

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How to evaluate the therapeutic strategy of TRPV1? 12/04/2022

Therapeutic strategies for TRPV1 include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against TRPV1 to inhibit its aberrant activity in the disease, or the regulation of TRPV1 expression through gene knockout or overexpression techniques.

Are there factors that can affect TRPV1 expression? 10/12/2022

A variety of factors can affect the expression of TRPV1, including capsaicin, acid, temperature, inflammatory factors, etc. These factors can stimulate the expression and activation of TRPV1, which in turn affects the perception of pain and temperature.

What drugs can act on TRPV1? 10/26/2021

At present, some drugs have been developed to act on TRPV1, including some small molecule inhibitors and antibody drugs. These drugs can inhibit the activity of TRPV1 or regulate its expression, thereby treating diseases associated with abnormal expression of TRPV1.

Which biomolecules can be used as molecular markers for TRPV1? 04/22/2021

Certain biomolecules can be used as molecular markers of TRPV1, such as mRNA or protein of TRPV1 detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.

What diseases are TRPV1 associated with? 09/24/2020

Studies have shown that the abnormal expression of TRPV1 is associated with the occurrence of a variety of diseases, including neuropathic pain, inflammatory pain, cardiovascular diseases, tumors, etc.

What is the main role of TRPV1 in the human body? 04/22/2020

TRPV1 is mainly involved in the perception of pain and temperature sensation in the human body. When the body is stimulated by heat, acid, or capsaicin, TRPV1 is activated, which in turn transmits pain signals.

Customer Reviews (3)

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Reviews
08/27/2023

    The stability is very good, and even if it is stored for a long time, it will not affect its performance.

    05/19/2021

      The anti-interference ability in Western blot is very strong, which can effectively resist the influence of endogenous interference factors and ensure the accuracy of experimental results.

      11/15/2020

        We trust the stability and reliability of their products and will continue to use them.

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