TRPV1
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Official Full Name
transient receptor potential cation channel, subfamily V, member 1
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Overview
The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It was the first isolated member of the transient receptor potential vanilloid receptor proteins which in turn are a sub family of the transient receptor potential protein group. This protein is a member of the TRPV group of transient receptor potential family of ion channels. -
Synonyms
Trpv1; transient receptor potential cation channel, subfamily V, member 1; Vr1; Vr1l1; VR.5"sv; transient receptor potential cation channel subfamily V member 1; OTRPC1; capsaicin receptor; vanilloid receptor 1;; osm-9-like TRP channel 1; vanilloid type 1 receptor; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- Flag
- TRxA
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- TRPV1 Related Articles
- TRPV1 Related Research Area
TRPV1 involved in several pathways and played different roles in them. We selected most pathways TRPV1 participated on our site, such as Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPV1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Neuroactive ligand-receptor interaction | RXFP3;HTR2CL1;THRB;TAAR12G;S1PR5A;GLRA3;GIPR;TAAR14H;GLRBB |
Inflammatory mediator regulation of TRP channels | CYP2C54;GNAQ;IGF1;PIK3R1;PLCG1;CALML5;CALM2;IL1B;KLK1B4 |
TRPV1 has several biochemical functions, for example, ATP binding, calcium channel activity, calcium-release channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPV1 itself. We selected most functions TRPV1 had, and list some proteins which have the same functions with TRPV1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | DCLK3;MCM8;UBE2N;FARS2;PRKACAA;UBE2E2;EK1;ASS1;AK7A |
calcium channel activity | CACNA1SA;CACNG7A;TRPC2B;AKR1C1;TRPC4A;PANX1;TMEM37;CACNG2A;TRPM2 |
calcium-release channel activity | RYR2;JPH2;RYR3;RYR1;RASA3;JPH3;TRPV1 |
calmodulin binding | CAMK1G;RGS16;MYO7A;MAP2;EPB41B;MARCKSB;PHKA1;MARCKSA;NDUFAF4 |
excitatory extracellular ligand-gated ion channel activity | |
phosphoprotein binding | PKD2;SRC;ARR3;CBX4;PIH1D1;FKBP4;APTX;RRAGA;SNCA |
transmembrane signaling receptor activity | LGR5;CLEC1B;LEPR;NRXN1;CD3D;TNFRSF10C;CD79A;NRXN2;BAI2 |
TRPV1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPV1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPV1.
- Q&As
- Reviews
Q&As (6)
Ask a questionTherapeutic strategies for TRPV1 include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against TRPV1 to inhibit its aberrant activity in the disease, or the regulation of TRPV1 expression through gene knockout or overexpression techniques.
A variety of factors can affect the expression of TRPV1, including capsaicin, acid, temperature, inflammatory factors, etc. These factors can stimulate the expression and activation of TRPV1, which in turn affects the perception of pain and temperature.
At present, some drugs have been developed to act on TRPV1, including some small molecule inhibitors and antibody drugs. These drugs can inhibit the activity of TRPV1 or regulate its expression, thereby treating diseases associated with abnormal expression of TRPV1.
Certain biomolecules can be used as molecular markers of TRPV1, such as mRNA or protein of TRPV1 detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
Studies have shown that the abnormal expression of TRPV1 is associated with the occurrence of a variety of diseases, including neuropathic pain, inflammatory pain, cardiovascular diseases, tumors, etc.
TRPV1 is mainly involved in the perception of pain and temperature sensation in the human body. When the body is stimulated by heat, acid, or capsaicin, TRPV1 is activated, which in turn transmits pain signals.
Customer Reviews (3)
Write a reviewThe stability is very good, and even if it is stored for a long time, it will not affect its performance.
The anti-interference ability in Western blot is very strong, which can effectively resist the influence of endogenous interference factors and ensure the accuracy of experimental results.
We trust the stability and reliability of their products and will continue to use them.
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