Recombinant Human TRPV1 Full Length Transmembrane protein, Flag-tagged(Nanodisc)
Cat.No. : | TRPV1-0944H |
Product Overview : | Recombinant Human Full Length TRPV1 protein with Flag tag was expressed in HEK293. |
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Source : | HEK293 |
Species : | Human |
Tag : | Flag |
Form : | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
Bio-activity : | Elisa plates were pre-coated with Flag Tag TRPV1-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with TRPV1-Nanodisc is 41.79ng/ml. |
Molecular Mass : | The human full length TRPV1 protein has a MW of 95.0 kDa. |
Storage : | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | TRPV1 transient receptor potential cation channel, subfamily V, member 1 [ Homo sapiens ] |
Official Symbol : | TRPV1 |
Synonyms : | TRPV1; transient receptor potential cation channel, subfamily V, member 1; vanilloid receptor subtype 1 , VR1; transient receptor potential cation channel subfamily V member 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; vanilloid receptor subtype 1; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; VR1; DKFZp434K0220; |
Gene ID : | 7442 |
mRNA Refseq : | NM_018727 |
Protein Refseq : | NP_061197 |
MIM : | 602076 |
UniProt ID : | Q8NER1 |
Products Types
◆ Recombinant Protein | ||
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TRPV1-345H | Recombinant Human TRPV1 Protein, His-tagged | +Inquiry |
TRPV1-17461M | Recombinant Mouse TRPV1 Protein | +Inquiry |
TRPV1-6303R | Recombinant Rat TRPV1 Protein | +Inquiry |
◆ Lysates | ||
TRPV1-735HCL | Recombinant Human TRPV1 293 Cell Lysate | +Inquiry |
TRPV1-734HCL | Recombinant Human TRPV1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionTherapeutic strategies for TRPV1 include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against TRPV1 to inhibit its aberrant activity in the disease, or the regulation of TRPV1 expression through gene knockout or overexpression techniques.
A variety of factors can affect the expression of TRPV1, including capsaicin, acid, temperature, inflammatory factors, etc. These factors can stimulate the expression and activation of TRPV1, which in turn affects the perception of pain and temperature.
At present, some drugs have been developed to act on TRPV1, including some small molecule inhibitors and antibody drugs. These drugs can inhibit the activity of TRPV1 or regulate its expression, thereby treating diseases associated with abnormal expression of TRPV1.
Certain biomolecules can be used as molecular markers of TRPV1, such as mRNA or protein of TRPV1 detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
Studies have shown that the abnormal expression of TRPV1 is associated with the occurrence of a variety of diseases, including neuropathic pain, inflammatory pain, cardiovascular diseases, tumors, etc.
TRPV1 is mainly involved in the perception of pain and temperature sensation in the human body. When the body is stimulated by heat, acid, or capsaicin, TRPV1 is activated, which in turn transmits pain signals.
Customer Reviews (3)
Write a reviewThe stability is very good, and even if it is stored for a long time, it will not affect its performance.
The anti-interference ability in Western blot is very strong, which can effectively resist the influence of endogenous interference factors and ensure the accuracy of experimental results.
We trust the stability and reliability of their products and will continue to use them.
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