Recombinant Human TRPV1 protein, His&Flag-tagged

• Cat.No.: TRPV1-1174HFL
• Product Overview: Recombinant Full Length Human TRPV1 protein(NP_061197)(1-839 aa), fused with His and Flag tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: His&Flag
• Form: Lyophilized from a 0.2 μm filtered solution in PBS, pH7.4 with 10% glycerin as protectant.
• Protein length: 1-839 aa
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied; 1 month, 2 to 8 °C under sterile conditions after reconstitution; 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Reconstitution: It is recommended to reconstitute the lyophilized powder in sterile water to 100-200 ug/ml, and further dilute with other solvents.It can be stored at 4°C for 2-7 days and should be used up as soon as possible. If not in use for a short time, please store at -20°C.

Gene Information

• Gene Name: TRPV1 transient receptor potential cation channel, subfamily V, member 1 [ Homo sapiens ]
• Official Symbol: TRPV1
• Synonyms: TRPV1; transient receptor potential cation channel, subfamily V, member 1; vanilloid receptor subtype 1 , VR1; transient receptor potential cation channel subfamily V member 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; vanilloid receptor subtype 1; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; VR1; DKFZp434K0220
• Gene ID: 7442
• mRNA Refseq: NM_018727
• Protein Refseq: NP_061197
• MIM: 602076
• UniProt ID: Q8NER1

Reviews

08/27/2023

The stability is very good, and even if it is stored for a long time, it will not affect its performance.

05/19/2021

The anti-interference ability in Western blot is very strong, which can effectively resist the influence of endogenous interference factors and ensure the accuracy of experimental results.

11/15/2020

We trust the stability and reliability of their products and will continue to use them.

Q&As

How to evaluate the therapeutic strategy of TRPV1?

Therapeutic strategies for TRPV1 include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against TRPV1 to inhibit its aberrant activity in the disease, or the regulation of TRPV1 expression through gene knockout or overexpression techniques.

Are there factors that can affect TRPV1 expression?

A variety of factors can affect the expression of TRPV1, including capsaicin, acid, temperature, inflammatory factors, etc. These factors can stimulate the expression and activation of TRPV1, which in turn affects the perception of pain and temperature.

What drugs can act on TRPV1?

At present, some drugs have been developed to act on TRPV1, including some small molecule inhibitors and antibody drugs. These drugs can inhibit the activity of TRPV1 or regulate its expression, thereby treating diseases associated with abnormal expression of TRPV1.

Which biomolecules can be used as molecular markers for TRPV1?

Certain biomolecules can be used as molecular markers of TRPV1, such as mRNA or protein of TRPV1 detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.

What diseases are TRPV1 associated with?

Studies have shown that the abnormal expression of TRPV1 is associated with the occurrence of a variety of diseases, including neuropathic pain, inflammatory pain, cardiovascular diseases, tumors, etc.

What is the main role of TRPV1 in the human body?

TRPV1 is mainly involved in the perception of pain and temperature sensation in the human body. When the body is stimulated by heat, acid, or capsaicin, TRPV1 is activated, which in turn transmits pain signals.