Recombinant Human TRPV1 protein, His-tagged
Cat.No. : | TRPV1-346H |
Product Overview : | Recombinant Human TRPV1 protein(NP_061197)(1-203 aa), fused to His tag, was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.). 5 % trehalose and 5 % mannitol are added as protectants before lyophilization. |
Protein length : | 1-203 aa |
AA Sequence : | MKKWSSTDLGAAADPLQKDTCPDPL DGDPNSRPPPAKPQLSTAKSRTRLF GKGDSEEAFPVDCPHEEGELDSCPT ITVSPVITIQRPGDGPTGARLLSQD SVAASTEKTLRLYDRRSIFEAVAQN NCQDLESLLLFLQKSKKHLTDNEFK DPETGKTCLLKAMLNLHDGQNTTIP LLLEIARQTDSLKELVNASYTDSYY KGQ |
Purity : | 75%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Storage : | Short-term storage: Store at 2-8°C for (1-2 weeks). Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Reconstitution : | Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage. Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage. |
Gene Name : | TRPV1 transient receptor potential cation channel, subfamily V, member 1 [ Homo sapiens ] |
Official Symbol : | TRPV1 |
Synonyms : | TRPV1; transient receptor potential cation channel, subfamily V, member 1; vanilloid receptor subtype 1 , VR1; transient receptor potential cation channel subfamily V member 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; vanilloid receptor subtype 1; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; VR1; DKFZp434K0220; |
Gene ID : | 7442 |
mRNA Refseq : | NM_018727 |
Protein Refseq : | NP_061197 |
MIM : | 602076 |
UniProt ID : | Q8NER1 |
Products Types
◆ Recombinant Protein | ||
TRPV1-9659M | Recombinant Mouse TRPV1 Protein, His (Fc)-Avi-tagged | +Inquiry |
TRPV1-5960R | Recombinant Rat TRPV1 Protein, His (Fc)-Avi-tagged | +Inquiry |
TRPV1-345H | Recombinant Human TRPV1 Protein, His-tagged | +Inquiry |
TRPV1-347M | Recombinant Mouse TRPV1 Protein, His&TRxA-tagged | +Inquiry |
TRPV1-6716Z | Recombinant Zebrafish TRPV1 | +Inquiry |
◆ Lysates | ||
TRPV1-734HCL | Recombinant Human TRPV1 293 Cell Lysate | +Inquiry |
TRPV1-735HCL | Recombinant Human TRPV1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionTherapeutic strategies for TRPV1 include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against TRPV1 to inhibit its aberrant activity in the disease, or the regulation of TRPV1 expression through gene knockout or overexpression techniques.
A variety of factors can affect the expression of TRPV1, including capsaicin, acid, temperature, inflammatory factors, etc. These factors can stimulate the expression and activation of TRPV1, which in turn affects the perception of pain and temperature.
At present, some drugs have been developed to act on TRPV1, including some small molecule inhibitors and antibody drugs. These drugs can inhibit the activity of TRPV1 or regulate its expression, thereby treating diseases associated with abnormal expression of TRPV1.
Certain biomolecules can be used as molecular markers of TRPV1, such as mRNA or protein of TRPV1 detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
Studies have shown that the abnormal expression of TRPV1 is associated with the occurrence of a variety of diseases, including neuropathic pain, inflammatory pain, cardiovascular diseases, tumors, etc.
TRPV1 is mainly involved in the perception of pain and temperature sensation in the human body. When the body is stimulated by heat, acid, or capsaicin, TRPV1 is activated, which in turn transmits pain signals.
Customer Reviews (3)
Write a reviewThe stability is very good, and even if it is stored for a long time, it will not affect its performance.
The anti-interference ability in Western blot is very strong, which can effectively resist the influence of endogenous interference factors and ensure the accuracy of experimental results.
We trust the stability and reliability of their products and will continue to use them.
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