tsc22d3
Share
  • Official Full Name
  • TSC22 domain family, member 3
  • Background
  • The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.
  • Synonyms
  • TSC22D3; TSC22 domain family, member 3; TSC22 domain family protein 3; TSC22 domain family 3; TSC22-related inducible leucine zipper 3; TSC22-related-inducible leucine zipper 3; delta sleep inducing peptide, immunoreactor; glucocorticoid-induced leucine zipper protein; long glucocorticoid-induced leucine zipper protein; DIP; Gilz; Dsip1; Tilz3; TSC-22R
Cat.#:TSC22D3-29062THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TSC22D3
+Inquiry
Cat.#:TSC22D3-29063THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TSC22D3
+Inquiry
Cat.#:TSC22D3-3443HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TSC22D3, GST-tagged
+Inquiry
Cat.#:TSC22D3-7192HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TSC22 Domain Family, Member 3, His-tagged
+Inquiry
Cat.#:TSC22D3-17477MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TSC22D3 Protein
+Inquiry
Cat.#:Tsc22d3-694MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tsc22d3 protein, His & T7-tagged
+Inquiry
Cat.#:TSC22D3-6311RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TSC22D3 Protein
+Inquiry
Cat.#:TSC22D3-4989RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TSC22D3 Protein, His-tagged
+Inquiry
Cat.#:TSC22D3-3512CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TSC22D3
+Inquiry
Cat.#:TSC22D3-10848ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TSC22D3
+Inquiry
Cat.#:TSC22D3-723HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TSC22D3 293 Cell Lysate
+Inquiry

Involved Pathway

TSC22D3 involved in several pathways and played different roles in them. We selected most pathways TSC22D3 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC22D3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ion channel transport
TRPC4A; CLCN6; CLCN2; NHEDC1; TTYH3; MCOLN3; BEST4; SRI; CLCNK; GABRR2A
Stimuli-sensing channels
ANO10A; BEST1; SLC9B2; CLCN4; TRPA1A; SRI; TTYH3; BEST3; Ano3; BSND
Transmembrane transport of small molecules
AQP9B; ATP2C2; RHCG2A; TRPC4A; SLC6A6; SLC6A11; ANO7; SLC6A19A; SLC39A8; AQP1A.2

Protein Function

TSC22D3 has several biochemical functions, for example, MRF binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC22D3 itself. We selected most functions TSC22D3 had, and list some proteins which have the same functions with TSC22D3. You can find most of the proteins on our site.
Function
Related Protein
Function MRF binding
Related Protein BHLHE40; CREBBP; KDM1A; TSC22D3
Function protein binding
Related Protein HER11; TRP63; GLYCTK; POLR3GL; IL12B; PTK7; SKP1; PDIA6; SEC22B; ESRRA
Function transcription factor activity, sequence-specific DNA binding
Related Protein POU3F3; AHRRB; TLX2; NOTCH1; ZNF227; NR2F5; POU2F1A; ZFP367; IRF4; MSRB2

Interacting Protein

TSC22D3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC22D3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC22D3.
TSC22D1; MTA2; lpd; DCLK2; PLEKHF2; HPCAL4

TSC22D3 Related Articles

Kavvoura, FK; Raimondo, A; et al. Reclassification of Diabetes Etiology in a Family With Multiple Diabetes Phenotypes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E1067-E1071(2014).
Kanthimathi, S; Jahnavi, S; et al. Glucokinase Gene Mutations (MODY 2) in Asian Indians. DIABETES TECHNOLOGY & THERAPEUTICS 16:180-185(2014).