ube2i
Share
  • Official Full Name
  • ubiquitin-conjugating enzyme E2I
  • Background
  • UBC9 is a member of the E2 ubiquitin-conjugating enzyme family that is involved in ubiquitin-dependent protein degradation system (1). Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin-protein ligases. UBC9 can function as a co-factor of PLAGL2, uncoupling its enzymatic activity to mediate PLAGL2 interactive SP-C promoter activity (2). UBC9 also plays an important role in the up-regulation of the bone morphogenetic protein signaling pathway.
  • Synonyms
  • UBE2I; ubiquitin-conjugating enzyme E2I; ubiquitin conjugating enzyme E2I (homologous to yeast UBC9) , ubiquitin conjugating enzyme E2I (UBC9 homolog, yeast); SUMO-conjugating enzyme UBC9; UBC9; SUMO-protein ligase; SUMO-1-protein ligase; ubiquitin-protein ligase I; ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin-protein ligase E2I; ubiquitin conjugating enzyme 9; ubiquitin-conjugating enzyme UbcE2A; ubiquitin-like protein SUMO-1 conjugating enzyme; ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9); P18; C358B7.1
Cat.#:UBE2I -03HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human UBE2I protein
+Inquiry
Cat.#:UBC9-3525HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2I protein, GST-tagged
+Inquiry
Cat.#:UBE2I-002HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2I protein, GST-tagged
+Inquiry
Cat.#:UBE2I-223HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2I, His-tagged
+Inquiry
Cat.#:UBE2I-34HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ubiquitin-conjugating Enzyme E2I
+Inquiry
Cat.#:UBE2I-856HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2I, None tagged
+Inquiry
Cat.#:UBE2I-17719MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UBE2I Protein
+Inquiry
Cat.#:UBE2I-6401RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UBE2I Protein
+Inquiry
Cat.#:UBE2I-5062RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey UBE2I Protein, His-tagged
+Inquiry
Cat.#:UBE2I-5838CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UBE2I
+Inquiry
Cat.#:UBE2I-03HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ubiquitin Conjugating Enzyme 9, His6-Tagged
+Inquiry
Cat.#:UBE2I-573HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human UBE2I 293 Cell Lysate
+Inquiry
Cat.#:UBE2I-574HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human UBE2I 293 Cell Lysate
+Inquiry

Involved Pathway

UBE2I involved in several pathways and played different roles in them. We selected most pathways UBE2I participated on our site, such as RNA transport, NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2I were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RNA transport
SUMO2B; EIF3G; TPRB; PABPC3; EIF3A; NUP214; EIF5B; DDX20; NXT2; STRAP
NF-kappa B signaling pathway
TICAM2; MYD88; CCL4; TNFAIP3; VCAM1; TRAF3; TNFSF11; BCL2A1; PRKCB; LRDD
Ubiquitin mediated proteolysis
TCEB1B; SIAH1; MGRN1A; UBE2E2; KEAP1; SMURF2; SIAH2L; UBE2N; PIAS4B; FBXO2
MicroRNAs in cancer
ERBB3; CDC25C; EFNA3; ZFPM2; SLC7A1; MDM4; HDAC1; TPM1; NOTCH1; SOS1

Protein Function

UBE2I has several biochemical functions, for example, ATP binding, HLH domain binding, RING-like zinc finger domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2I itself. We selected most functions UBE2I had, and list some proteins which have the same functions with UBE2I. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TIMM44; P2RX7; P2RX8; WNK1; CDK12; KIF23; DCLK3; HSPH1; DARS; MYHZ2
Function HLH domain binding
Related Protein UBE2I; SIRT1; PKD2
Function RING-like zinc finger domain binding
Related Protein BMI1; RNF2; UBE2I
Function SUMO conjugating enzyme activity
Related Protein UBE2I
Function SUMO transferase activity
Related Protein SUMO4; SUMO3; UBE2IA; SUMO1; UBE2I; CBX4; PIAS4; UBE2IB; NSMCE2; PIAS3
Function enzyme binding
Related Protein ACAT1; CBS; CAT; DDX5; TAL1; SLC12A3; ERN1; UBE2L3; TTN; NOP14
Function ligase activity
Related Protein RBBP6; TTLL11; MID2; RNF213; RNF19B; NAPRT; HUWE1; UBE3A; RANBP2; TNFAIP3
Function poly(A) RNA binding
Related Protein HIST1H4J; MRPL37; DKC1; ACTN4; FAU; YTHDF1; YBX1; MRPL22; PKM; NSA2
Function protein binding
Related Protein TGFB2; HIPK2; HNRNPR; PTPN14; YAF2; TMEM174; MEOX2; ACVR2B; ISOC2; ALDOC
Function transcription factor binding
Related Protein KCTD1; SNF8; HDAC9; RARA; DIP2BA; AHR; PAXBP1; MED6; SOX8; CREBBP
Function NOT ubiquitin protein ligase activity
Related Protein UBE2IA; VHLL; UBE2M; UBE2IB; UBE2F; UBE2I
Function NOT ubiquitin protein ligase binding
Related Protein UBE2I; UBE2IA; UBE2F; UBE2M; UBE2IB

Interacting Protein

UBE2I has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2I here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2I.
RANGAP1; SUMO1; PIAS2

UBE2I Related Articles

Tahmasebi, S; Ghorbani, M; et al. The SUMO Conjugating Enzyme Ubc9 Is Required for Inducing and Maintaining Stem Cell Pluripotency. STEM CELLS 32:1012-1020(2014).
Oh, Y; Chung, KC; et al. UHRF2, a Ubiquitin E3 Ligase, Acts as a Small Ubiquitin-like Modifier E3 Ligase for Zinc Finger Protein 131. JOURNAL OF BIOLOGICAL CHEMISTRY 288:9102-9111(2013).