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UBE2I

  • Official Full Name

    ubiquitin-conjugating enzyme E2I

  • Overview

    UBC9 is a member of the E2 ubiquitin-conjugating enzyme family that is involved in ubiquitin-dependent protein degradation system (1). Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin-protein ligases. UBC9 can function as a co-factor of PLAGL2, uncoupling its enzymatic activity to mediate PLAGL2 interactive SP-C promoter activity (2). UBC9 also plays an important role in the up-regulation of the bone morphogenetic protein signaling pathway.
  • Synonyms

    UBE2I; ubiquitin-conjugating enzyme E2I; ubiquitin conjugating enzyme E2I (homologous to yeast UBC9) , ubiquitin conjugating enzyme E2I (UBC9 homolog, yeast); SUMO-conjugating enzyme UBC9; UBC9; SUMO-protein ligase; SUMO-1-protein ligase; ubiquitin-protein ligase I; ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin-protein ligase E2I; ubiquitin conjugating enzyme 9; ubiquitin-conjugating enzyme UbcE2A; ubiquitin-like protein SUMO-1 conjugating enzyme; ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9); P18; C358B7.1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UBE2I-002H Recombinant Human UBE2I protein, GST-tagged E.coli GST
Human UBE2I-223H Recombinant Human UBE2I, His-tagged E.coli His
Human UBE2I-03H Recombinant Human Ubiquitin Conjugating Enzyme 9, His6-Tagged E.coli His
Human UBC9-3525H Recombinant Human UBE2I protein, GST-tagged E.coli GST
Human UBE2I-34H Recombinant Human Ubiquitin-conjugating Enzyme E2I E.coli N/A
Human UBE2I-856H Recombinant Human UBE2I protein(Met1-Ser158) E. coli N/A Met1-Ser158
Human UBE2I-573HCL Recombinant Human UBE2I 293 Cell Lysate HEK293 N/A
Human UBE2I-574HCL Recombinant Human UBE2I 293 Cell Lysate HEK293 N/A
Human UBE2I-516H Recombinant Human UBE2I Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human UBE2I-0010H Recombinant Human UBE2I Protein (S2-S158), His/Strep tagged Insect Cell His/Strep S2-S158
Human UBE2I-2905H Recombinant Human UBE2I Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human UBE2I -03H Recombinant Human UBE2I protein E.coli N/A 171
Human UBE2I-4545H Recombinant Human UBE2I Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human UBE2I-6532H Recombinant Human UBE2I Protein (Asp33-Ser158), N-His tagged E.coli N-His Asp33-Ser158
Human UBE2I-0009H Recombinant Human UBE2I Protein (S2-S158), Tag Free Insect Cell No tag S2-S158
Mouse UBE2I-17719M Recombinant Mouse UBE2I Protein Mammalian Cell His
Mouse Ube2i-6789M Recombinant Mouse Ube2i Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse UBE2I-9830M Recombinant Mouse UBE2I Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse UBE2I-9830M-B Recombinant Mouse UBE2I Protein Pre-coupled Magnetic Beads HEK293
Rat UBE2I-6401R Recombinant Rat UBE2I Protein Mammalian Cell His
Rat UBE2I-6057R-B Recombinant Rat UBE2I Protein Pre-coupled Magnetic Beads HEK293
Rat UBE2I-6057R Recombinant Rat UBE2I Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque UBE2I-5062R Recombinant Rhesus monkey UBE2I Protein, His-tagged Mammalian Cell His
Rhesus Macaque UBE2I-4875R-B Recombinant Rhesus Macaque UBE2I Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque UBE2I-4875R Recombinant Rhesus Macaque UBE2I Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken UBE2I-5838C Recombinant Chicken UBE2I Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • UBE2I Related Articles
  • UBE2I Related Research Area
  • UBE2I Related Signal Pathway

UBE2I involved in several pathways and played different roles in them. We selected most pathways UBE2I participated on our site, such as RNA transport, NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2I were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA transportNUP107;EIF3HA;NUP37;EIF3S10;EIF3I;PABPC1;NUP54;BAT1;UPF3B
NF-kappa B signaling pathwayCD40;XIAP;RELB;TNF;TNFAIP3;PRKCQ;UBE2I;TNFRSF11A;TICAM2
Ubiquitin mediated proteolysisRFWD2;KEAP1B;UBE3B;PIAS4A;SOCS1A;UBE3C;UBE2A;BIRC2;CUL3A
MicroRNAs in cancerSERPINB5;ERBB3;IKBKB;MTOR;PRKCA;NRAS;ST14;PDGFRB;WNT3A

UBE2I has several biochemical functions, for example, ATP binding, HLH domain binding, RING-like zinc finger domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2I itself. We selected most functions UBE2I had, and list some proteins which have the same functions with UBE2I. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSPS2;KIF3B;PANK1A;ATP1A4;ATP8B3;ZAK;PFTK1;NTRK2;RIPK4
HLH domain bindingPKD2;UBE2I;SIRT1
RING-like zinc finger domain bindingUBE2I;RNF2;BMI1
SUMO conjugating enzyme activity
SUMO transferase activityCBX4;PIAS3;UBE2IB;NSMCE2;PIAS4;MUL1;SUMO1;TOPORS;UBE2I
enzyme bindingMLEC;ARPC4;HDAC3;P4HB;HSPA5;SUPT5H;PHKG2;HIST1H2AM;NR5A1
ligase activityHERC5;TRIM21;PJA1;LIPT2;RNF152;RNF20;HECW2;BRAP;RNF135
poly(A) RNA bindingRBM8A;KCTD12;REPIN1;TMSB4X;GPATCH8;ZFP36;HERC5;SAMD4B;CS
protein bindingSYNDIG1;NOL4;PRR16;MACROD1;LIMD2;SYN1;BLOC1S1;CUL9;C9orf9
transcription factor bindingTRP53;RBPJ;FIGLA;CEBPB;TLE1;TCF3;NFIA;LMO4;MAPK9
NOT ubiquitin protein ligase activityUBE2IA;UBE2I;VHLL;UBE2M;UBE2IB;UBE2F
NOT ubiquitin protein ligase bindingUBE2F;UBE2IA;UBE2IB;UBE2M;UBE2I

UBE2I has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2I here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2I.

RANGAP1; SUMO1; PIAS2

Tahmasebi, S; Ghorbani, M; et al. The SUMO Conjugating Enzyme Ubc9 Is Required for Inducing and Maintaining Stem Cell Pluripotency. STEM CELLS 32:1012-1020(2014).
Oh, Y; Chung, KC; et al. UHRF2, a Ubiquitin E3 Ligase, Acts as a Small Ubiquitin-like Modifier E3 Ligase for Zinc Finger Protein 131. JOURNAL OF BIOLOGICAL CHEMISTRY 288:9102-9111(2013).
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