UBE2I Protein, ubiquitin-conjugating enzyme E2I


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Official Full Name ubiquitin-conjugating enzyme E2I
Background UBC9 is a member of the E2 ubiquitin-conjugating enzyme family that is involved in ubiquitin-dependent protein degradation system (1). Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin-protein ligases. UBC9 can function as a co-factor of PLAGL2, uncoupling its enzymatic activity to mediate PLAGL2 interactive SP-C promoter activity (2). UBC9 also plays an important role in the up-regulation of the bone morphogenetic protein signaling pathway.
Synonyms UBE2I; ubiquitin-conjugating enzyme E2I; ubiquitin conjugating enzyme E2I (homologous to yeast UBC9) , ubiquitin conjugating enzyme E2I (UBC9 homolog, yeast); SUMO-conjugating enzyme UBC9; UBC9; SUMO-protein ligase; SUMO-1-protein ligase; ubiquitin-protein ligase I; ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin-protein ligase E2I; ubiquitin conjugating enzyme 9; ubiquitin-conjugating enzyme UbcE2A; ubiquitin-like protein SUMO-1 conjugating enzyme; ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9); P18; C358B7.1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBE2I -03H Recombinant Human UBE2I protein E.coli N/A
    Human UBC9-3525H Recombinant Human UBE2I protein, GST-tagged E.coli GST
    Human UBE2I-002H Recombinant Human UBE2I protein, GST-tagged E.coli GST
    Human UBE2I-03H Recombinant Human Ubiquitin Conjugating Enzyme 9, His6-Tagged E.coli His
    Human UBE2I-223H Recombinant Human UBE2I, His-tagged E.coli His
    Human UBE2I-34H Recombinant Human Ubiquitin-conjugating Enzyme E2I E.coli N/A
    Human UBE2I-573HCL Recombinant Human UBE2I 293 Cell Lysate HEK293 N/A
    Human UBE2I-574HCL Recombinant Human UBE2I 293 Cell Lysate HEK293 N/A
    Human UBE2I-856H Recombinant Human UBE2I, None tagged E.coli N/A
    Mouse UBE2I-17719M Recombinant Mouse UBE2I Protein Mammalian Cell His
    Rat UBE2I-6401R Recombinant Rat UBE2I Protein Mammalian Cell His
    Rhesus Macaque UBE2I-5062R Recombinant Rhesus monkey UBE2I Protein, His-tagged Mammalian Cell His
    Chicken UBE2I-5838C Recombinant Chicken UBE2I Mammalian Cell His

    UBE2I involved in several pathways and played different roles in them. We selected most pathways UBE2I participated on our site, such as RNA transport, NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2I were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport PNN; RPP25; EIF4BB; EIF2S3Y; UPF3A; EIF3C; PABPC5; EIF3F; SIP1; EIF2S2
    NF-kappa B signaling pathway UBE2I; LCK; NFKB1; TNFRSF13C; TNFRSF1A; GM13304; BLNK; RIPK1; CCL4; DDX58
    Ubiquitin mediated proteolysis ANAPC5; CDC27; ANAPC2; UBA7; UBE3C; CUL4B; UBR5; UBE2D1A; TCEB2; KLHL9
    MicroRNAs in cancer UBE2I; CCNG1; GLS; KRAS; PDGFB; TTC6; ABCB1A; SPRY2; ABCB1; Abcb1b

    UBE2I has several biochemical functions, for example, ATP binding, HLH domain binding, RING-like zinc finger domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2I itself. We selected most functions UBE2I had, and list some proteins which have the same functions with UBE2I. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ACTR1A; LIG3; SARS2; ADCY6; RAD54L; GRK5; TYK2; PTK2AA; MAPK15; TRMU
    HLH domain binding UBE2I; PKD2; SIRT1
    RING-like zinc finger domain binding BMI1; RNF2; UBE2I
    SUMO conjugating enzyme activity UBE2I
    SUMO transferase activity PIAS4; SUMO3; CBX4; TOPORS; UBE2IB; SUMO4; MUL1; PIAS3; NSMCE2; SUMO1
    enzyme binding LDB2; BIRC7; PRKCD; MAT2B; CBX3; MAPT; MTA1; DYM; DDC; TP53
    ligase activity TRIM33; TRIM56; ZFP91; CTPS1A; TRIM17; RNF133; RNF220; RNF123; UBE2CBP; C12orf51
    poly(A) RNA binding PHF5A; SCG3; SF3B14; SAP18; ERH; RPL27; MAGOH2; CNOT1; GRWD1; KIAA0020
    protein binding ILVBL; CALCRL; MAPK3; L3MBTL1; ULK2; GABARAPL1; DCP2; RNF4; AP1G2; EPCAM
    transcription factor binding GPX3; CEBPB; HDAC7; FOS; E2F5; CDK9; TWIST1; ID1; IFI16; IFT172
    NOT ubiquitin protein ligase activity UBE2IA; UBE2IB; VHLL; UBE2I; UBE2M; UBE2F
    NOT ubiquitin protein ligase binding UBE2IA; UBE2F; UBE2I; UBE2IB; UBE2M

    UBE2I has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2I here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2I.


    Tahmasebi, S; Ghorbani, M; et al. The SUMO Conjugating Enzyme Ubc9 Is Required for Inducing and Maintaining Stem Cell Pluripotency. STEM CELLS 32:1012-1020(2014).
    Oh, Y; Chung, KC; et al. UHRF2, a Ubiquitin E3 Ligase, Acts as a Small Ubiquitin-like Modifier E3 Ligase for Zinc Finger Protein 131. JOURNAL OF BIOLOGICAL CHEMISTRY 288:9102-9111(2013).

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