usp8
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  • Official Full Name
  • ubiquitin specific peptidase 8
  • Background
  • Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action. Five DUB subfamilies are recognized, including the USP, UCH, OTU, MJD and JAMM enzymes. The deubiquitinating enzyme, ubi
  • Synonyms
  • USP8; ubiquitin specific peptidase 8; ubiquitin specific protease 8; ubiquitin carboxyl-terminal hydrolase 8; HumORF8; KIAA0055; UBPY; hUBPy; ubiquitin isopeptidase Y; ubiquitin thioesterase 8; deubiquitinating enzyme 8; ubiquitin thiolesterase 8; ubiquit
Cat.#:USP8-127HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP8
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Cat.#:USP8-161HTag:His/SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP8, His & SUMO-tagged
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Cat.#:USP8-162HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP8, His-tagged
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Cat.#:USP8-86HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human USP8, FLAG-tagged
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Cat.#:USP8-5132RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey USP8 Protein, His-tagged
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Cat.#:USP8-451HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human USP8 293 Cell Lysate
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Involved Pathway

USP8 involved in several pathways and played different roles in them. We selected most pathways USP8 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
EGFRA; CHMP4A; SMAD3; MHC1UXA2; GIT2; DNM2B; IL2RA; RLN1; RHOA; IGF2R

Protein Function

USP8 has several biochemical functions, for example, SH3 domain binding, cysteine-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP8 itself. We selected most functions USP8 had, and list some proteins which have the same functions with USP8. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein SHANK2; PTTG2; CD2AP; CD3E; DTX1; AFAP1L2; UVRAG; MICAL1; EVLB; CTTNBP2
Function cysteine-type endopeptidase activity
Related Protein DUB1; CTSSB.2; USP45; CTLA2B; CTSBA; USP28; ATG4D; USP48; USP18; ATG4A
Function protein binding
Related Protein TDRD7; TBX22; C14orf104; HDAC4; SH3GL2; SIRT6; ITSN2; SRGAP2; THEG; SF3A2
Function ubiquitin-specific protease activity
Related Protein USP47; USP2; USP22; UCHL3; OTUB1A; USP24; ZRANB1B; USP2A; USP34; OTUB2

Interacting Protein

USP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP8.
YWHAZ; CHMP1B; YWHAB; Grap2; CHMP1A; CHMP4C