WDR1 Protein, WD repeat domain 1

WDR1

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WDR1

Official Full Name WD repeat domain 1
Background This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms WDR1; WD repeat domain 1; WD repeat-containing protein 1; Actin interacting protein 1; AIP1; D5Wsu185e; NORI 1; actin-interacting protein 1; NORI-1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human WDR1-1213H Recombinant Human WDR1 Protein (189-461 aa), GST-tagged E.coli GST
    Human WDR1-357HCL Recombinant Human WDR1 293 Cell Lysate HEK293 N/A
    Mouse WDR1-18449M Recombinant Mouse WDR1 Protein Mammalian Cell His
    Rat WDR1-6564R Recombinant Rat WDR1 Protein Mammalian Cell His
    Chicken WDR1-1220C Recombinant Chicken WDR1 Mammalian Cell His
    Zebrafish WDR1-11270Z Recombinant Zebrafish WDR1 Mammalian Cell His

    WDR1 involved in several pathways and played different roles in them. We selected most pathways WDR1 participated on our site, such as Hemostasis, Hypertrophy Model, Platelet activation, signaling and aggregation, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hemostasis KIF11; F9A; KIF9; HBB-BH1; KIF15; PHF21A; GATA5; PRTN3; CAP1; AKAP10
    Hypertrophy Model HBEGFB; MSTN; MSTNB; CYR61; JUND; DUSP14; ANKRD1; ZEB1B; IFRD1; ADAM10A
    Platelet activation, signaling and aggregation HRG; CD9A; SPARC; GNA13B; MMRN2A; MMRN1; RHOGA; STXBP3A; C6orf25; BRPF3
    Platelet degranulation SPARC; CAP1; GAS6; CD9A; F13A1B; IGF2B; BRPF3; CALU; CLU; AASS
    Response to elevated platelet cytosolic Ca2+ MMRN2A; CLU; WDR1; F13A1A.1; STXBP3A; PLEK; F13A1B; CAP1; CD9A; STXBP3

    WDR1 has several biochemical functions, for example, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR1 itself. We selected most functions WDR1 had, and list some proteins which have the same functions with WDR1. You can find most of the proteins on our site.

    Function Related Protein
    actin binding TPM3; ARPC5L; KLHL1; WASF1; FLNC; ANLN; SNTB2; MYPN; PARK2; MYHZ2

    WDR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR1.

    GRB2; SRPK1; TNFRSF10D; CSNK2B; SKIV2L; q8clp4_yerpe; ere_dna; MYO1C; FLNA; MYH9; IQGAP1; CAPZA2; NUP107; Tpm1; PPP1CB; BIRC3; BIRC2

    Izawa, S; Okamura, T; et al. Autoantibody against WD repeat domain 1 is a novel serological biomarker for screening of thyroid neoplasia. CLINICAL ENDOCRINOLOGY 79:35-42(2013).
    Izawa, S; Taniguchi, S; et al. Anti-WDR1 Antibody: A Novel Biochemical Marker for the Differential Diagnosis of Thyroid Neoplasm.. ENDOCRINE REVIEWS 31:-(2010).

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