ABCG2

  • Official Full Name

    ATP-binding cassette, sub-family G (WHITE), member 2

  • Overview

    The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
  • Synonyms

    ABCG2; ATP-binding cassette, sub-family G (WHITE), member 2; MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; CDw338; UAQTL1; EST157481; ATP-binding cassette sub-family G member 2; urate exporter; ABC transporter; placenta specific MDR protein; breast cancer resistance protein; ATP-binding cassette transporter G2; mitoxantrone resistance-associated protein; placenta-specific ATP-binding cassette transporter; multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • eGFP, Strep II,10His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABCG2-065H Recombinant Human ABCG2 Protein Wheat Germ N/A
Human ABCG2-19H Recombinant Human ABCG2, GST-tagged Wheat Germ GST
Human ABCG2-067H Recombinant Human ABCG2 Protein, GST-Tagged Wheat Germ GST
Human ABCG2-659H Recombinant Human ABCG2 Mammalian Cell His
Human ABCG2-5672H Recombinant Human ABCG2 protein, His-tagged E.coli His Met1~Pro290
Human ABCG2-066H Recombinant Human ABCG2 Protein, GST-Tagged Wheat Germ GST
Human ABCG2-045H Recombinant Human ABCG2 protein, His-Myc-tagged Yeast His/Myc 557-630aa
Human ABCG2-2404H Recombinant Human ABCG2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ABCG2-0160H Recombinant Human ABCG2 Protein (M1-S655), eGFP, Strep II, 10×His tagged Insect Cell eGFP, Strep II,10His M1-S655
Human ABCG2-187H Recombinant Human ABCG2 Protein, C-His-tagged E.coli C-His
Human ABCG2-1536H Recombinant Human ABCG2 Protein (Asn557-His630), N-His tagged E.coli N-His Asn557-His630
Human ABCG2-2404H-B Recombinant Human ABCG2 Protein Pre-coupled Magnetic Beads HEK293
Mouse ABCG2-1115M Recombinant Mouse ABCG2 Protein Mammalian Cell His
Mouse Abcg2-5673M Recombinant Mouse Abcg2 protein, His & T7-tagged E.coli His/T7 Leu63~Leu349 (Accession # Q7TMS5)
Mouse ABCG2-207M Recombinant Mouse ABCG2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ABCG2-207M-B Recombinant Mouse ABCG2 Protein Pre-coupled Magnetic Beads HEK293
Rat ABCG2-414R Recombinant Rat ABCG2 Protein Mammalian Cell His
Rat ABCG2-69R Recombinant Rat ABCG2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ABCG2-69R-B Recombinant Rat ABCG2 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL17173BF Recombinant Full Length Bovine Atp-Binding Cassette Sub-Family G Member 2(Abcg2) Protein, His-Tagged E.coli expression system His Full Length (1-655)
Homo sapiens (Human) RFL32177HF Recombinant Full Length Human Atp-Binding Cassette Sub-Family G Member 2(Abcg2) Protein, His-Tagged E.coli expression system His Full Length (1-655)
Macaca mulatta (Rhesus macaque) RFL22577MF Recombinant Full Length Macaca Mulatta Atp-Binding Cassette Sub-Family G Member 2(Abcg2) Protein, His-Tagged E.coli expression system His Full Length (1-654)
Mus musculus (Mouse) RFL35359MF Recombinant Full Length Mouse Atp-Binding Cassette Sub-Family G Member 2(Abcg2) Protein, His-Tagged E.coli expression system His Full Length (1-657)
Rattus norvegicus (Rat) RFL36450RF Recombinant Full Length Rat Atp-Binding Cassette Sub-Family G Member 2(Abcg2) Protein, His-Tagged E.coli expression system His Full Length (1-657)
Rhesus Macaque ABCG2-184R Recombinant Rhesus monkey ABCG2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ABCG2-13R Recombinant Rhesus Macaque ABCG2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ABCG2-13R-B Recombinant Rhesus Macaque ABCG2 Protein Pre-coupled Magnetic Beads HEK293
Sus scrofa (Pig) RFL17608SF Recombinant Full Length Pig Atp-Binding Cassette Sub-Family G Member 2(Abcg2) Protein, His-Tagged E.coli expression system His Full Length (1-656)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ABCG2 involved in several pathways and played different roles in them. We selected most pathways ABCG2 participated on our site, such as ABC transporters, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ABC transportersABCB10;ABCC12;ABCB11;ABCD2;ABCG5;ABCB1A;ABCC9;ABCD3A;ABCD3
Bile secretionHMGCR;CYP7A1;SLC9A1;SLC51A;ATP1A1;ABCG2;ABCB11;ATP1A3;ABCG8

ABCG2 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, heme transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCG2 itself. We selected most functions ABCG2 had, and list some proteins which have the same functions with ABCG2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSRPK2;GARS;MAP2K5;KARS;DYRK4;OASL1;NTRK3;BMP2K;KIF22
ATPase activity, coupled to transmembrane movement of substancesSFRP5;ABCG2A;ABCD2;ABCA9;ABCC5;ABCC8;Abca2;ABCA13;ABCG5
heme transporter activityHPX;HRG-1;ABCG2;MFSD7C;FLVCR1;SLC48A1B;ABCB7;SLC48A1A;MFSD7B
protein bindingLASP1;SRA1;TMEM149;IGFBP5;PCBP1;MOB4;MAPK8;GAST;TBCB
protein homodimerization activityCTBP2A;APOA4;UPK1A;LCN2;ALDH5A1;RPL7;TPR;SERPINF2;BAK1
transporter activitySEC22A;FABP7A;SLC4A2A;SLC37A4;MUP17;FABP11B;HIATL2;NUP153;SLC2A1A
xenobiotic-transporting ATPase activityABCB4;ABCB1;ABCG2;ABCB1A;Abcb1b

ABCG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCG2.

PIM1; UBC; Trim69

Research Area

Related articles

Diaz-Torne, C; Perez-Herrero, N; et al. New medications in development for the treatment of hyperuricemia of gout. CURRENT OPINION IN RHEUMATOLOGY 27:164-169(2015).
Zhao, MC; Zhang, YS; et al. Hypoxia-induced cell stemness leads to drug resistance and poor prognosis in lung adenocarcinoma. LUNG CANCER 87:98-106(2015).
  • Q&As
  • Reviews

Q&As (20)

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What are the functional consequences of ABCG1 deficiency or overexpression? 01/17/2023

ABCG1 deficiency or overexpression can have functional consequences on cellular lipid metabolism. Deficiency of ABCG1 may lead to impaired cholesterol efflux and lipid accumulation, while overexpression of ABCG1 can enhance cholesterol efflux and improve lipid homeostasis.

Are there any known inhibitors or modulators of ABCG2 that could have therapeutic implications? 10/07/2022

Several inhibitors and modulators of ABCG2 have been identified, and they have potential therapeutic implications. These compounds can block the efflux function of ABCG2, thereby increasing the intracellular concentrations of co-administered drugs and overcoming ABCG2-mediated drug resistance. 

What is the fucntion of ABCG2 protein? 01/07/2021

It actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. In addition, it Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme

What is the clinical relevance of ABCG2 in cancer and its implications for chemotherapy? 09/10/2020

ABCG2 has clinical relevance in cancer due to its role in multidrug resistance. Overexpression of ABCG2 in cancer cells can lead to reduced intracellular drug concentrations, limiting the effectiveness of chemotherapy

Are there any genetic variations or polymorphisms in the ABCG2 gene associated with altered drug response or increased susceptibility to diseases? 08/03/2020

Yes, there are known genetic variations and polymorphisms in the ABCG2 gene associated with altered drug response and increased susceptibility to certain diseases. One well-studied polymorphism is the Q141K variant, which has been shown to affect ABCG2 function and alter drug pharmacokinetics. 

How is the expression of ABCG1 regulated in different cell types or tissues? 04/06/2020

The expression of ABCG1 can be regulated at the transcriptional level in response to changes in cellular cholesterol levels. Various transcription factors and signaling pathways, such as liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs), can influence ABCG1 expression.

Which species are the portein of ABCG2 present in? 10/11/2019

It presents in bovine, human, mouse, zebrafish and A.thaliana.

What are the specific substrates transported by ABCG2? 07/11/2019

ABCG2 transports a broad range of substrates, including chemotherapeutic drugs, such as mitoxantrone, topotecan, and methotrexate, as well as various endogenous molecules, such as heme, uric acid, and bilirubin. 

Are there any pharmacological approaches or strategies to enhance the efficacy of ABCG2 substrates in cancer treatment? 10/03/2018

One strategy involves using specific ABCG2 inhibitors to block its efflux function, thereby increasing the intracellular concentration of co-administered anticancer drugs. Another approach is to develop prodrugs that are selectively activated inside cancer cells, bypassing the efflux activity of ABCG2. Furthermore, combination therapies that target multiple pathways involved in drug resistance, including ABCG2, are being explored to overcome multidrug resistance in cancer.

Does ABCG2 play a role in the development and progression of neurodegenerative diseases? 08/27/2018

ABCG2 is expressed in the blood-brain barrier and plays a role in protecting the brain from potentially harmful substances. Dysregulation of ABCG2 expression or function has been implicated in the accumulation of neurotoxic compounds, such as amyloid-beta peptides, in neurodegenerative disorders like Alzheimer's disease.

How is ABCG2 expression regulated in different tissues and cell types? 04/17/2018

ABCG2 expression is controlled by various transcription factors and signaling pathways, including nuclear factor erythroid 2-related factor 2 (NRF2) and pregnane X receptor (PXR). Additionally, genetic and epigenetic factors can influence ABCG2 expression levels.

What is the mechanism of action of the ABCG1 protein? 12/06/2017

The ABCG1 protein functions as an ATP-binding cassette (ABC) transporter involved in cellular lipid metabolism. It promotes the efflux of cholesterol and other lipids from cells, contributing to cholesterol homeostasis.

How is ABCG2 involved in the efflux of anticancer drugs and the development of multidrug resistance? 11/30/2017

ABCG2 is involved in the efflux of anticancer drugs and contributes to the development of multidrug resistance. Cancer cells can overexpress ABCG2, which reduces the intracellular accumulation of chemotherapeutic agents and limits their effectiveness. This efflux activity of ABCG2 enables cancer cells to evade the cytotoxic effects of drugs, leading to treatment failure and disease recurrence.

Are there any tissue-specific differences in ABCG2 expression and function? 07/17/2017

Yes, there are tissue-specific differences in ABCG2 expression and function. ABCG2 is highly expressed in tissues with barrier functions, such as the intestines, liver, kidneys, and blood-brain barrier. This tissue-specific expression pattern reflects the role of ABCG2 in protecting these barriers from toxic compounds. 

Can ABCG2 polymorphisms influence drug response and toxicity in different populations? 05/24/2017

 Yes, ABCG2 polymorphisms can influence drug response and toxicity in different populations. Several genetic variations in the ABCG2 gene have been identified, some of which are associated with altered protein function and drug pharmacokinetics. These polymorphisms can affect the expression, transport activity, and substrate specificity of ABCG2, leading to variations in drug response and toxicity profiles. 

What is the impact of ABCG2 on the bioavailability and distribution of dietary phytochemicals or natural products? 03/05/2017

ABCG2 may impact the bioavailability and distribution of dietary phytochemicals or natural products. It is known to be involved in the efflux of certain dietary compounds, including flavonoids and polyphenols. ABCG2 activity can influence their absorption, metabolism, and tissue distribution, potentially affecting their bioactivity and health benefits

What is the role of ABCG2 in cellular transport and drug resistance? 01/15/2017

ABCG2 plays a crucial role in cellular transport and drug resistance. It is an efflux transporter that helps to eliminate various endogenous and exogenous compounds from cells, including drugs, toxins, and metabolites.

What is the role of ABCG2 in protecting against xenobiotic and environmental toxin exposure? 12/05/2016

ABCG2 plays a role in protecting against xenobiotic and environmental toxin exposure. It functions as a defense mechanism by actively pumping out harmful substances from cells, thereby reducing their intracellular concentrations. This protective role is particularly important in barrier tissues, such as the intestines and blood-brain barrier, where ABCG2 helps prevent the entry of toxins into the body or restrict their distribution to sensitive organs.

Does ABCG2 play a role in stem cell biology and tissue development? 09/06/2016

 ABCG2 has been found to play a role in stem cell biology and tissue development. It is expressed in various stem cell populations, including hematopoietic stem cells and neural stem cells. ABCG2 contributes to the maintenance and protection of stem cells by regulating the efflux of various substrates, including toxins and reactive oxygen species. Its activity helps to preserve the self-renewal capacity and differentiation potential of stem cells.

How does the substrated transported by ABCG2 affect drug disposition? 09/04/2016

The transport of these substrates by ABCG2 impacts drug disposition, tissue distribution, and elimination. ABCG2 is localized on the apical membrane of epithelial cells, where it contributes to the efflux of substrates into the luminal or extracellular space.

Customer Reviews (5)

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Reviews
02/14/2020

     its clear instructions provided a seamless user experience

    11/03/2017

      It remained active and retaining its functional properties even under varying storage conditions

      08/04/2017

        It played a crucial role in my experiments

        07/13/2017

          The protein product demonstrated remarkable specificity.

          03/12/2016

            The company's willingness to go the extra mile in resolving a shipping issue.

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