Recombinant Mouse Abcg2 protein, His & T7-tagged

• Cat.No.: Abcg2-5673M
• Product Overview: Recombinant Mouse Abcg2 aa. (Leu63~Leu349 (Accession # Q7TMS5)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Species: Mouse
• Source: E.coli
• Tag: His&T7
• Protein Length: Leu63~Leu349
• Description: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 34.9kDa
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 5.8.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Concentration: 200μg/mL
• Storage buffer: Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
• Reconstitution: Reconstitute in sterile ddH2O.

Gene Information

• Gene Name: Abcg2 ATP-binding cassette, sub-family G (WHITE), member 2 [ Mus musculus (house mouse) ]
• Official Symbol: Abcg2
• Synonyms: Abcg2; ATP-binding cassette, sub-family G (WHITE), member 2; MXR; ABCP; BCRP; MXR1; ABC15; Bcrp1; AI428558; ATP-binding cassette sub-family G member 2; breast cancer resistance protein 1 homolog; mitoxantrone resistance protein 1; urate exporter
• Gene ID: 26357
• mRNA Refseq: NM_011920.3
• Protein Refseq: NP_036050.1
• UniProt ID: Q7TMS5