Recombinant Rat ABCG2 Protein
Cat.No. : | ABCG2-414R |
Product Overview : | Recombinant Rat ABCG2 full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Rat |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 [ Rattus norvegicus ] |
Official Symbol : | ABCG2 |
Gene ID : | 312382 |
mRNA Refseq : | NM_181381.2 |
Protein Refseq : | NP_852046.1 |
MIM : | |
UniProt ID : | Q80W57 |
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Not For Human Consumption!
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Customer Reviews (5)
Write a reviewits clear instructions provided a seamless user experience
It remained active and retaining its functional properties even under varying storage conditions
It played a crucial role in my experiments
The protein product demonstrated remarkable specificity.
The company's willingness to go the extra mile in resolving a shipping issue.
Q&As (20)
Ask a questionABCG1 deficiency or overexpression can have functional consequences on cellular lipid metabolism. Deficiency of ABCG1 may lead to impaired cholesterol efflux and lipid accumulation, while overexpression of ABCG1 can enhance cholesterol efflux and improve lipid homeostasis.
Several inhibitors and modulators of ABCG2 have been identified, and they have potential therapeutic implications. These compounds can block the efflux function of ABCG2, thereby increasing the intracellular concentrations of co-administered drugs and overcoming ABCG2-mediated drug resistance.
It actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. In addition, it Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme
ABCG2 has clinical relevance in cancer due to its role in multidrug resistance. Overexpression of ABCG2 in cancer cells can lead to reduced intracellular drug concentrations, limiting the effectiveness of chemotherapy
Yes, there are known genetic variations and polymorphisms in the ABCG2 gene associated with altered drug response and increased susceptibility to certain diseases. One well-studied polymorphism is the Q141K variant, which has been shown to affect ABCG2 function and alter drug pharmacokinetics.
The expression of ABCG1 can be regulated at the transcriptional level in response to changes in cellular cholesterol levels. Various transcription factors and signaling pathways, such as liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs), can influence ABCG1 expression.
It presents in bovine, human, mouse, zebrafish and A.thaliana.
ABCG2 transports a broad range of substrates, including chemotherapeutic drugs, such as mitoxantrone, topotecan, and methotrexate, as well as various endogenous molecules, such as heme, uric acid, and bilirubin.
One strategy involves using specific ABCG2 inhibitors to block its efflux function, thereby increasing the intracellular concentration of co-administered anticancer drugs. Another approach is to develop prodrugs that are selectively activated inside cancer cells, bypassing the efflux activity of ABCG2. Furthermore, combination therapies that target multiple pathways involved in drug resistance, including ABCG2, are being explored to overcome multidrug resistance in cancer.
ABCG2 is expressed in the blood-brain barrier and plays a role in protecting the brain from potentially harmful substances. Dysregulation of ABCG2 expression or function has been implicated in the accumulation of neurotoxic compounds, such as amyloid-beta peptides, in neurodegenerative disorders like Alzheimer's disease.
ABCG2 expression is controlled by various transcription factors and signaling pathways, including nuclear factor erythroid 2-related factor 2 (NRF2) and pregnane X receptor (PXR). Additionally, genetic and epigenetic factors can influence ABCG2 expression levels.
The ABCG1 protein functions as an ATP-binding cassette (ABC) transporter involved in cellular lipid metabolism. It promotes the efflux of cholesterol and other lipids from cells, contributing to cholesterol homeostasis.
ABCG2 is involved in the efflux of anticancer drugs and contributes to the development of multidrug resistance. Cancer cells can overexpress ABCG2, which reduces the intracellular accumulation of chemotherapeutic agents and limits their effectiveness. This efflux activity of ABCG2 enables cancer cells to evade the cytotoxic effects of drugs, leading to treatment failure and disease recurrence.
Yes, there are tissue-specific differences in ABCG2 expression and function. ABCG2 is highly expressed in tissues with barrier functions, such as the intestines, liver, kidneys, and blood-brain barrier. This tissue-specific expression pattern reflects the role of ABCG2 in protecting these barriers from toxic compounds.
Yes, ABCG2 polymorphisms can influence drug response and toxicity in different populations. Several genetic variations in the ABCG2 gene have been identified, some of which are associated with altered protein function and drug pharmacokinetics. These polymorphisms can affect the expression, transport activity, and substrate specificity of ABCG2, leading to variations in drug response and toxicity profiles.
ABCG2 may impact the bioavailability and distribution of dietary phytochemicals or natural products. It is known to be involved in the efflux of certain dietary compounds, including flavonoids and polyphenols. ABCG2 activity can influence their absorption, metabolism, and tissue distribution, potentially affecting their bioactivity and health benefits
ABCG2 plays a crucial role in cellular transport and drug resistance. It is an efflux transporter that helps to eliminate various endogenous and exogenous compounds from cells, including drugs, toxins, and metabolites.
ABCG2 plays a role in protecting against xenobiotic and environmental toxin exposure. It functions as a defense mechanism by actively pumping out harmful substances from cells, thereby reducing their intracellular concentrations. This protective role is particularly important in barrier tissues, such as the intestines and blood-brain barrier, where ABCG2 helps prevent the entry of toxins into the body or restrict their distribution to sensitive organs.
ABCG2 has been found to play a role in stem cell biology and tissue development. It is expressed in various stem cell populations, including hematopoietic stem cells and neural stem cells. ABCG2 contributes to the maintenance and protection of stem cells by regulating the efflux of various substrates, including toxins and reactive oxygen species. Its activity helps to preserve the self-renewal capacity and differentiation potential of stem cells.
The transport of these substrates by ABCG2 impacts drug disposition, tissue distribution, and elimination. ABCG2 is localized on the apical membrane of epithelial cells, where it contributes to the efflux of substrates into the luminal or extracellular space.
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