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Official Full Name acetylcholinesterase (Yt blood group)
Background Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.
Synonyms ACHE; acetylcholinesterase (Yt blood group); YT; ACEE; ARACHE; N-ACHE
    • Species :
    • Bovine
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Human Cell
    • Human Erythrocyte
    • Mammalian Cell
    • Trichoplusia Ni Larval
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ACHE-04H Recombinant Human ACHE Protein, His-tagged HEK293 His
    Bovine ACHE-2476B Recombinant Bovine ACHE protein, GST-tagged E.coli GST
    Human ACHE-09H Recombinant Human ACHE, His-tagged Trichoplusia Ni Larval His
    Human ACHE-101H Recombinant Human ACHE, His-tagged E.coli His
    Human ACHE-105H Recombinant Human ACHE protein, His-tagged CHO His
    Human ACHE-106H Recombinant Human ACHE protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ACHE-1175H Recombinant Human ACHE Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ACHE-130H Recombinant Human ACHE Mammalian Cell His
    Human ACHE-156H Recombinant Human ACHE Protein, GST-Tagged Wheat Germ GST
    Human ACHE-8345H Native Human ACHE Human Erythrocyte N/A
    Human ACHE-9289H Recombinant Human ACHE, GST-tagged E.coli GST
    Mouse Ache-07M Recombinant Mouse Ache, His-tagged Trichoplusia Ni Larval His
    Mouse Ache-08M Recombinant Mouse Ache Trichoplusia Ni Larval N/A
    Mouse ACHE-2163MCL Recombinant Mouse ACHE cell lysate Human Cell N/A
    Mouse AchE-3060M Recombinant Mouse AchE, His-tagged E.coli His
    Mouse Ache-511M Recombinant Mouse Ache Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Ache-774M Recombinant Mouse Ache, His tagged Human Cell His
    Rat ACHE-450R Recombinant Rat ACHE Protein Mammalian Cell His
    Rat Ache-6971R Recombinant Rat Ache protein, His-tagged E.coli His
    Rat Ache-6972R Recombinant Rat Ache protein, His-tagged E.coli His
    Rhesus Macaque ACHE-208R Recombinant Rhesus monkey ACHE Protein, His-tagged Mammalian Cell His
    Bovine ACHE-3059B Recombinant Bovine ACHE, gst-tagged E.Coli or Yeast GST
    Chicken ACHE-6969C Recombinant Chicken ACHE Mammalian Cell His
    Zebrafish ACHE-9352Z Recombinant Zebrafish ACHE Mammalian Cell His
    Kit-0031 Acetylcholinesterase Activity Colorimetric Assay Kit N/A
    Kit-0032 Acetylcholinesterase Assay Kit N/A
    Kit-0033 Acetylcholinesterase Green Fluorescence Assay Kit N/A
    Kit-0034 Acetylcholinesterase Red Fluorescence Assay Kit N/A
    Kit-0035 Acetylcholinesterase Fluorometric Detection Kit N/A

    Ache involved in several pathways and played different roles in them. We selected most pathways Ache participated on our site, such as Glycerophospholipid metabolism, Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ache were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid metabolism STIL; CDS2; PLA2G1B; PLA2G2A; GPD1L; PLD3; PLA2G12B; DGKA; CDIPT; PEMT
    Cholinergic synapse MAP2K1; PIK3CG; GNB3; KCNJ12; CREB3L2; GNG4; ITPR1; CHRNA6; AKT1; BCL2

    Ache has several biochemical functions, for example, acetylcholine binding, acetylcholinesterase activity, beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ache itself. We selected most functions Ache had, and list some proteins which have the same functions with Ache. You can find most of the proteins on our site.

    Function Related Protein
    acetylcholine binding CHRFAM7A; CHRNB2; CHRNA3; CHRNA7; CHRNB1; CHRNA4; CHRNB3; ACHE; CHRM3
    acetylcholinesterase activity BCHE; ACHE
    beta-amyloid binding MAPK8IP2; Apba1; APBB2; HBA-A2; ACHE; BACE1; APOEA; FBXO2; TGFB2; ARMCX5-GPRASP2
    cholinesterase activity CEL.1; ACHE; CELL; BCHE; CHKA
    collagen binding CTSK; MMP9; ITGA1; PODN; PCOLCE2; MMP13; C1QTNF1; SMAD4; SRGN; NID1
    hydrolase activity TDRD9; ATP2B1A; MEP1A.2; DESI2; NUDT19; CNOT6; DDX19; LYZ1; CHD6; Reln
    laminin binding PLEKHA2; THBS1; ECM1; CTSS; ITGB1; ACHE; ITGA9; LGALS2A; NID1; ITGA7
    protein binding PPP6R3; PIK3IP1; PES1; VPS53; ASPSCR1; TEKT5; RUNX1T1; CRIPT; MVK; DDR1
    protein homodimerization activity PPP2R4; G6PD; CEP57; DMRT3A; Pdgfa&Pdgfb; ANXA1; SUMF1; GALE; TCF12; GSTM1
    protein self-association PTH1R; CNTN2; ACHE; ABCD3; NKX3; ZSWIM2; AGXT; AXIN1; EPB49; DVL2
    serine hydrolase activity CELA2A; AADAC; ACHE

    Ache has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ache here. Most of them are supplied by our site. Hope this information will be useful for your research of Ache.

    COLQ; ENO1; GNB2L1; acetylcholine; 2-phospho-d-glyceric acid; 3se1_denan; acetyl-beta-methyl-thiocholine; neostigmine; Eno1; ATF7; Gnb2l1

    Carod-Artal, FJ; et al. Illness due the Ebola virus: epidemiology and clinical manifestations within the context of an international public health emergency. REVISTA DE NEUROLOGIA 60:267-277(2015).
    Verma, N; Bhardwaj, A; et al. Biosensor Technology for Pesticides-A review. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 175:3093-3119(2015).

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