Recombinant Human ACHE, GST-tagged
Cat.No. : | ACHE-9289H |
Product Overview : | Recombinant Human ACHE protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-351a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | ACHE acetylcholinesterase [ Homo sapiens ] |
Official Symbol : | ACHE |
Synonyms : | ACHE; acetylcholinesterase; acetylcholinesterase (YT blood group) , acetylcholinesterase (Yt blood group) , YT; Yt blood group; apoptosis-related acetylcholinesterase; YT; ACEE; ARACHE; N-ACHE; |
Gene ID : | 43 |
mRNA Refseq : | NM_000665 |
Protein Refseq : | NP_000656 |
MIM : | 100740 |
UniProt ID : | P22303 |
Chromosome Location : | 7q22 |
Pathway : | ATF-2 transcription factor network, organism-specific biosystem; Acetylcholine Synthesis, organism-specific biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Glycerophospholipid metabolism, organism-specific biosystem; Glycerophospholipid metabolism, conserved biosystem; Monoamine Transport, organism-specific biosystem; |
Function : | acetylcholine binding; acetylcholine binding; acetylcholinesterase activity; acetylcholinesterase activity; beta-amyloid binding; carboxylesterase activity; cholinesterase activity; collagen binding; hydrolase activity; laminin binding; protein binding; p |
Products Types
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ACHE-2415H | Recombinant Human ACHE Protein, His (Fc)-Avi-tagged | +Inquiry |
ACHE-106R | Recombinant Rat ACHE Protein, His (Fc)-Avi-tagged | +Inquiry |
ACHE-04H | Active Recombinant Human ACHE Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
ACHE-8345H | Native Human ACHE | +Inquiry |
◆ Lysates | ||
ACHE-2163MCL | Recombinant Mouse ACHE cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0032 | Acetylcholinesterase Assay Kit | +Inquiry |
Kit-0033 | Acetylcholinesterase Green Fluorescence Assay Kit | +Inquiry |
Kit-0031 | Acetylcholinesterase Activity Colorimetric Assay Kit | +Inquiry |
Kit-0034 | Acetylcholinesterase Red Fluorescence Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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