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ACSL3

  • Official Full Name

    acyl-CoA synthetase long-chain family member 3

  • Overview

    The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    ACSL3; acyl-CoA synthetase long-chain family member 3; FACL3, fatty acid Coenzyme A ligase, long chain 3; long-chain-fatty-acid--CoA ligase 3; ACS3; PRO2194; LACS 3; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 3; fatty-acid-Coenzyme A ligase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACSL3-196H Recombinant Human ACSL3 Protein, GST-tagged Wheat Germ GST
Human ACSL3-26480TH Recombinant Human ACSL3, His-tagged E.coli His
Human ACSL3-197H Recombinant Human ACSL3 Protein, GST-tagged Wheat Germ GST
Human ACSL3-9076HCL Recombinant Human ACSL3 293 Cell Lysate HEK293 N/A
Human ACSL3-9077HCL Recombinant Human ACSL3 293 Cell Lysate HEK293 N/A
Human ACSL3-1483H Recombinant Human ACSL3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human ACSL3-53H Recombinant Human ACSL3 Protein, His-tagged E.coli N-His Gln473-Lys720
Human ACSL3-796H Recombinant Human ACSL3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ACSL3-261H Recombinant Human ACSL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ACSL3-261H-B Recombinant Human ACSL3 Protein Pre-coupled Magnetic Beads HEK293
Human ACSL3-789HF Recombinant Full Length Human ACSL3 Protein, GST-tagged In Vitro Cell Free System GST 720 amino acids
Human ACSL3-1459HFL Recombinant Full Length Human ACSL3 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Acsl3-9319M Recombinant Mouse Acsl3, GST-tagged E.coli GST 1-302a.a.
Mouse ACSL3-1226M Recombinant Mouse ACSL3 Protein Mammalian Cell His
Mouse ACSL3-273M-B Recombinant Mouse ACSL3 Protein Pre-coupled Magnetic Beads HEK293
Mouse ACSL3-273M Recombinant Mouse ACSL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Acsl3-1506M Recombinant Mouse Acsl3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Acsl3-54M Recombinant Mouse Acsl3 Protein, His-tagged E.coli N-His Cys450-Lys720
Rat ACSL3-470R Recombinant Rat ACSL3 Protein Mammalian Cell His
Rat ACSL3-126R Recombinant Rat ACSL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ACSL3-126R-B Recombinant Rat ACSL3 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL-34899HF Recombinant Full Length Human Long-Chain-Fatty-Acid--Coa Ligase 3(Acsl3) Protein, His-Tagged E.coli expression system His Full Length (1-720)
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ACSL3 involved in several pathways and played different roles in them. We selected most pathways ACSL3 participated on our site, such as Fatty acid biosynthesis, Fatty acid degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid biosynthesisACSBG1;OLAH;ACACA;OXSM;ACSL1;ACACB;ACSL4;ECHDC2;ACSL3
Fatty acid degradationGCDHA;ACADS;ACSL5;ADH5;ALDH9A1;ACAT2;HADH;CYP4A10;ADH1B
Metabolic pathwaysDBH;CYP2P8;CYP51;DLDH;RDH10;NDUFB9;GLUD1B;ST6GALNAC5;SAT1A.2
Fatty acid metabolismTECR;ACACA;FASN;MCAT;CPT1B;SCD;ACSL1B;ELOVL2;ACSL1
PPAR signaling pathwayAQP7;ACAA1A;APOA2;PPARD;CYP4A12A;SLC27A4;RXRAA;RXRBA;PPARG
PeroxisomeACAA1A;EPHX2;PEX5L;ACSL3A;ACOX2;DAO.1;HMGCL;PIPOX;PEX11G
Adipocytokine signaling pathwayIRS2;SLC2A4;CPT1A;TRAF2;ACSL1;CAMKK2;PTPN11A;ADIPOR1;RXRGA

ACSL3 has several biochemical functions, for example, ATP binding, long-chain fatty acid-CoA ligase activity, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL3 itself. We selected most functions ACSL3 had, and list some proteins which have the same functions with ACSL3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSYK;TSSK2;HK2;ABCA5;NPR1A;GLULB;BMPR1AA;UBE2D2;STK25A
long-chain fatty acid-CoA ligase activityACSL4;SLC27A2;ACSBG1;SLC27A5;SLC27A4;SLC27A3;ACSL3;ACSL1;SLC27A1A
protein domain specific bindingMECP2;NLRP1;KPNB1;HSPA5;HIST1H4J;NCK1;UNC13A;MRPL17;ARFIP2
protein kinase bindingEPHA1;PEBP1;ACSL3;SLC12A4;RPS6KA3;FER;SPDYA;KAT2B;BAG5

ACSL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL3.

vpu; GTF2F2; NDRG1; Chek1; ACSL4; PPP6R2; EGFR; 1C; ERBB2; KIF11; REEP5; TIGD6; TMEM173; SPG20; HIPK4; SKA1; KIF20B; Rassf1

  • Q&As
  • Reviews

Q&As (10)

Ask a question
What is the relationship between ACSL3 and cardiovascular disease? 07/18/2022

ACSL3 dysregulation has been linked to the development of cardiovascular disease, highlighting the importance of the gene in the regulation of lipid metabolism and cardiovascular health.

What is the impact of ACSL3 on autophagy? 01/15/2022

ACSL3 has been shown to impact autophagy, a cellular process involved in the breakdown and recycling of damaged or dysfunctional cellular components.

What is the relationship between ACSL3 and insulin resistance? 07/10/2021

ACSL3 dysregulation has been implicated in the development of insulin resistance, a common feature of many metabolic disorders.

What is the impact of ACSL3 on adipogenesis? 01/19/2021

ACSL3 has been shown to impact adipogenesis, the process of fat cell differentiation, by regulating the availability of long-chain fatty acids for lipid synthesis and storage.

What is the structure of the ACSL3 protein? 01/19/2021

The ACSL3 protein consists of multiple domains, including an N-terminal domain, a central domain, and a C-terminal domain, which are involved in substrate binding, acyl-adenylate formation, and ATP binding, respectively.

What is the impact of ACSL3 on cellular signaling pathways? 08/01/2020

ACSL3 has been shown to impact cellular signaling pathways, particularly those involved in the regulation of inflammation, insulin signaling, and energy metabolism.

What is the role of ACSL3 in lipid metabolism? 07/01/2020

ACSL3 plays a critical role in lipid metabolism by activating long-chain fatty acids for subsequent utilization in various metabolic pathways, including β-oxidation and the production of signaling lipids.

What is the expression pattern of ACSL3 in different tissues? 05/20/2020

ACSL3 is expressed in a variety of tissues, including adipose tissue, liver, muscle, heart, and brain, with highest expression levels observed in adipose tissue.

How does ACSL3 impact lipid droplet formation? 04/30/2020

ACSL3 has been shown to impact lipid droplet formation, with increased expression of the gene leading to enhanced lipid droplet formation and storage.

How does ACSL3 impact cellular proliferation and differentiation? 06/03/2018

ACSL3 has been shown to impact cellular proliferation and differentiation by modulating the availability of long-chain fatty acids for various cellular processes.

Customer Reviews (5)

Write a review
Reviews
06/14/2021

    The product was well-characterized, and the documentation provided was thorough and helpful.

    08/27/2020

      The protein arrived quickly and was exactly what I needed for my experiment. Very satisfied with my purchase.

      06/01/2020

        The website was easy to navigate and the ordering process was simple. Appreciate the user-friendly interface.

        10/04/2019

          I'm really pleased with my purchase of the recombinant protein. It's high quality and reasonably priced.

          09/01/2018

            I appreciate the transparency and honesty of this company in their communication with customers. Will continue to order from them in the future.

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