ACSL3
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Official Full Name
acyl-CoA synthetase long-chain family member 3
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Overview
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
ACSL3; acyl-CoA synthetase long-chain family member 3; FACL3, fatty acid Coenzyme A ligase, long chain 3; long-chain-fatty-acid--CoA ligase 3; ACS3; PRO2194; LACS 3; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 3; fatty-acid-Coenzyme A ligase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ACSL3 involved in several pathways and played different roles in them. We selected most pathways ACSL3 participated on our site, such as Fatty acid biosynthesis, Fatty acid degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fatty acid biosynthesis | ACSBG1;OLAH;ACACA;OXSM;ACSL1;ACACB;ACSL4;ECHDC2;ACSL3 |
Fatty acid degradation | GCDHA;ACADS;ACSL5;ADH5;ALDH9A1;ACAT2;HADH;CYP4A10;ADH1B |
Metabolic pathways | DBH;CYP2P8;CYP51;DLDH;RDH10;NDUFB9;GLUD1B;ST6GALNAC5;SAT1A.2 |
Fatty acid metabolism | TECR;ACACA;FASN;MCAT;CPT1B;SCD;ACSL1B;ELOVL2;ACSL1 |
PPAR signaling pathway | AQP7;ACAA1A;APOA2;PPARD;CYP4A12A;SLC27A4;RXRAA;RXRBA;PPARG |
Peroxisome | ACAA1A;EPHX2;PEX5L;ACSL3A;ACOX2;DAO.1;HMGCL;PIPOX;PEX11G |
Adipocytokine signaling pathway | IRS2;SLC2A4;CPT1A;TRAF2;ACSL1;CAMKK2;PTPN11A;ADIPOR1;RXRGA |
ACSL3 has several biochemical functions, for example, ATP binding, long-chain fatty acid-CoA ligase activity, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL3 itself. We selected most functions ACSL3 had, and list some proteins which have the same functions with ACSL3. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | SYK;TSSK2;HK2;ABCA5;NPR1A;GLULB;BMPR1AA;UBE2D2;STK25A |
long-chain fatty acid-CoA ligase activity | ACSL4;SLC27A2;ACSBG1;SLC27A5;SLC27A4;SLC27A3;ACSL3;ACSL1;SLC27A1A |
protein domain specific binding | MECP2;NLRP1;KPNB1;HSPA5;HIST1H4J;NCK1;UNC13A;MRPL17;ARFIP2 |
protein kinase binding | EPHA1;PEBP1;ACSL3;SLC12A4;RPS6KA3;FER;SPDYA;KAT2B;BAG5 |
ACSL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL3.
vpu; GTF2F2; NDRG1; Chek1; ACSL4; PPP6R2; EGFR; 1C; ERBB2; KIF11; REEP5; TIGD6; TMEM173; SPG20; HIPK4; SKA1; KIF20B; Rassf1
- Q&As
- Reviews
Q&As (10)
Ask a questionACSL3 dysregulation has been linked to the development of cardiovascular disease, highlighting the importance of the gene in the regulation of lipid metabolism and cardiovascular health.
ACSL3 has been shown to impact autophagy, a cellular process involved in the breakdown and recycling of damaged or dysfunctional cellular components.
ACSL3 dysregulation has been implicated in the development of insulin resistance, a common feature of many metabolic disorders.
ACSL3 has been shown to impact adipogenesis, the process of fat cell differentiation, by regulating the availability of long-chain fatty acids for lipid synthesis and storage.
The ACSL3 protein consists of multiple domains, including an N-terminal domain, a central domain, and a C-terminal domain, which are involved in substrate binding, acyl-adenylate formation, and ATP binding, respectively.
ACSL3 has been shown to impact cellular signaling pathways, particularly those involved in the regulation of inflammation, insulin signaling, and energy metabolism.
ACSL3 plays a critical role in lipid metabolism by activating long-chain fatty acids for subsequent utilization in various metabolic pathways, including β-oxidation and the production of signaling lipids.
ACSL3 is expressed in a variety of tissues, including adipose tissue, liver, muscle, heart, and brain, with highest expression levels observed in adipose tissue.
ACSL3 has been shown to impact lipid droplet formation, with increased expression of the gene leading to enhanced lipid droplet formation and storage.
ACSL3 has been shown to impact cellular proliferation and differentiation by modulating the availability of long-chain fatty acids for various cellular processes.
Customer Reviews (5)
Write a reviewThe product was well-characterized, and the documentation provided was thorough and helpful.
The protein arrived quickly and was exactly what I needed for my experiment. Very satisfied with my purchase.
The website was easy to navigate and the ordering process was simple. Appreciate the user-friendly interface.
I'm really pleased with my purchase of the recombinant protein. It's high quality and reasonably priced.
I appreciate the transparency and honesty of this company in their communication with customers. Will continue to order from them in the future.
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