ACTB

  • Official Full Name

    actin, beta
  • Overview

    This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]
  • Synonyms

    ACTB;actin, beta;BRWS1;PS1TP5BP1;actin, cytoplasmic 1;beta cytoskeletal actin;PS1TP5-binding protein 1

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Cynomolgus
  • Mouse
  • Rat
  • Chicken
  • Cricetulus Griseus
  • Porcine
  • Human Platelets
  • Mammalian Cells
  • E.coli
  • E.Coli/Yeast
  • HEK293
  • Yeast
  • Porcine Brain
  • Insect Cells
  • Non
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
ACTB-325H Active Native Human ACTB Human Platelets Human Non
ACTB-133H Recombinant Human ACTB Mammalian Cells Human His
ACTB-221R Recombinant Rhesus monkey ACTB Protein, His-tagged Mammalian Cells Rhesus macaque His
ACTB-225H Recombinant Human ACTB protein, His-tagged E.coli Human His Met1-Phe375
ACTB-269C Recombinant Cynomolgus ACTB Protein, His-tagged Mammalian Cells Cynomolgus His
ACTB-3030H Recombinant Human Actin, Beta, His-tagged E.coli Human His 1-375 a.a.
Actb-3093M Recombinant Mouse Actb, His-tagged E.Coli/Yeast Mouse His 375
ACTB-478R Recombinant Rat ACTB Protein Mammalian Cells Rat His
ACTB-7067C Recombinant Chicken ACTB Mammalian Cells Chicken His
ACTB-20HCL Recombinant Human ACTB cell lysate Human Non
ACTB-074H Recombinant Human ACTB Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
ACTB-124H Recombinant Human ACTB Protein, His-tagged E.coli Human His
ACTB-134R Recombinant Rat ACTB Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ACTB-134R-B Recombinant Rat ACTB Protein Pre-coupled Magnetic Beads HEK293 Rat
ACTB-19C Recombinant Cynomolgus Monkey ACTB Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
ACTB-19C-B Recombinant Cynomolgus Monkey ACTB Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
ACTB-2433C Recombinant Cricetulus Griseus ACTB Protein (1-375 aa), His-Myc-tagged Yeast Cricetulus Griseus His&Myc 1-375 aa
ACTB-2449C Recombinant Cricetulus Griseus ACTB Protein (1-375 aa), His-tagged E.coli Cricetulus Griseus His 1-375 aa
ACTB-2480H Recombinant Human ACTB protein, His&Myc-tagged E.coli Human His&Myc 1-375aa
ACTB-2481H Recombinant Human ACTB protein, His-tagged E.coli Human His 102-375aa
ACTB-267H Recombinant Human ACTB Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
ACTB-267H-B Recombinant Human ACTB Protein Pre-coupled Magnetic Beads HEK293 Human
ACTB-28HFL Recombinant Full Length Human ACTB Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
ACTB-49R Recombinant Rhesus Macaque ACTB Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
ACTB-49R-B Recombinant Rhesus Macaque ACTB Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Actb-812M Recombinant Mouse Actb Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
ACTB-882P Native Porcine ACTB Protein Porcine Brain Porcine Non
ACTB-938H Recombinant Human ACTB protein, His&Myc-tagged Insect Cells Human His&Myc 1-375aa

    Involved Pathway

    ACTB involved in several pathways and played different roles in them. We selected most pathways ACTB participated on our site, such as Rap signaling pathway,Phagosome,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bacterial invasion of epithelial cells CAV2,DNM1,ITGA5,BCAR1,PIK3R1,CLTA,SEPT6,FN1,CBLB,RAC1
    Rap signaling pathway PLCB4,HGF,SIPA1L1,PDGFRB,PLCE1,FGF2,AKT1,FGF3,PIK3CA,RAC1
    Proteoglycans in cancer CTTN,CAMK2G,WNT5B,ERBB4,TRP53,GPC3,RRAS,CAV2,IGF2,TIMP3
    Viral myocarditis SGCD,CAV1,ABL2,SGCB,CD28,BID,HLA-A,Casp3,HLA-DRB5,ITGB2
    Hippo signaling pathway PPP1CB,MOB1A,MPP5,APC2,FZD9,GLI2,CCND1,PPP1CA,AXIN2,GSK3B
    Phagosome SEC22BB,STX7,PIKFYVE,TLR2-2,TUBA1L2,EEA1,CD209A,Pla2r1,RAC1B,ATP6V1B1
    Influenza A HLA-DQA2,TMPRSS2,CASP1,AGFG1,TNFRSF10C,TNFRSF10D,LOC100686744,IFNAR1,SLC25A6,STAT1
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGB1,ITGA2,ITGB6,CACNG7,ITGB3,ITGA10,ITGA6,LEF1,CACNG1,ACTN3
    Pathogenic Escherichia coli infection ROCK1,TUBA3E,WAS,ARHGEF2,TUBB6,TUBB1,RHOA,KRT18,ARPC5L,TUBB

    Protein Function

    ACTB has several biochemical functions, for example, ATP binding,contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding,contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTB itself. We selected most functions ACTB had, and list some proteins which have the same functions with ACTB. You can find most of the proteins on our site.

    Function Related Protein
    nitric-oxide synthase binding SLC14A2,SNTA1,DNM2,DMD,SCN5A,CAMK2D,CAV3,DNM3,CALM3,SLC6A4
    kinesin binding MAPK8IP2,KIAA1279,NUP62,KCNC1,NEFH,KLC3,NEK6,KLC2,KIFAP3B,KIFAP3A
    Tat protein binding MDFIC,DLL1,GABARAPL1,SMARCA4,NPM1,TRIM32,SMARCB1
    protein binding EML2,MARK4,SOX7,USP15,RPL23A,GATA2,FAP,AUP1,PRMT3,CABLES1
    ATP binding NLRP1,FES,RTEL1,PDPK1,MAP4K5,MAPK9,MAP3K11,RIOK3,ACVR1L,LCK
    identical protein binding ALCAMA,CHMP4B,TTN,APP,GYPA,TP53,SIRT1,AGXT2,VIL1,PTPRG
    contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding MBD3,SMARCE1,SMARCA4,HDAC2,ACTL6A,RBBP4,CHD4,SMARCB1,SMARCC2,SMARCC1
    contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding CHD4,RBBP4,SMARCC1,HDAC1,HDAC2,GATAD2B,MTA2,SMARCA4,SMARCB1,SMARCC2
    contributes_to nucleosomal DNA binding GATAD2B,RBBP4,MTA2,HDAC2,SMARCB1,MBD3,CHD4,HDAC1,SMARCE1,ACTL6A

    Interacting Protein

    ACTB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTB here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTB.

    ACTG1;CFL1;DSTN;ESR1

    Resources

    References

    • Bonnans, C; Lohela, M; et al. Real-time Imaging of Myeloid Cells Dynamics in Apc(Min/+) Intestinal Tumors by Spinning Disk Confocal Microscopy. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2014).
    • Matsumoto, C; Ito, M; et al. Preparation of thyroid follicular cells for mRNA quantification after fluorescence-activated cell sorting. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 73:245-252(2013).

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