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ACTL6B

  • Official Full Name

    actin-like 6B

  • Overview

    The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.
  • Synonyms

    ACTL6B; actin-like 6B; actin like 6 , ACTL6; actin-like protein 6B; BAF53B; arpNalpha; hArpN alpha; actin-like 6; BRG1-associated factor 53B; actin-related protein Baf53b; 53 kDa BRG1-associated factor B; ACTL6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACTL6B-26300TH Recombinant Human ACTL6B, His-tagged E.coli His
Human ACTL6B-223H Recombinant Human ACTL6B Protein, GST-tagged Wheat Germ GST
Human ACTL6B-9060HCL Recombinant Human ACTL6B 293 Cell Lysate HEK293 N/A
Human ACTL6B-846HF Recombinant Full Length Human ACTL6B Protein, GST-tagged In Vitro Cell Free System GST 426 amino acids
Human ACTL6B-301380H Recombinant Human ACTL6B protein, GST-tagged E.coli GST Thr40-Met82
Mouse ACTL6B-1245M Recombinant Mouse ACTL6B Protein Mammalian Cell His
Mouse ACTL6B-286M-B Recombinant Mouse ACTL6B Protein Pre-coupled Magnetic Beads HEK293
Mouse ACTL6B-286M Recombinant Mouse ACTL6B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Actl6b-3101R Recombinant Rat Actl6b, His-tagged E.Coli or Yeast His 426
Rat ACTL6B-482R Recombinant Rat ACTL6B Protein Mammalian Cell His
Rat ACTL6B-138R Recombinant Rat ACTL6B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ACTL6B-138R-B Recombinant Rat ACTL6B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ACTL6B-223R Recombinant Rhesus monkey ACTL6B Protein, His-tagged Mammalian Cell His
Rhesus Macaque ACTL6B-51R-B Recombinant Rhesus Macaque ACTL6B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ACTL6B-51R Recombinant Rhesus Macaque ACTL6B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ACTL6B-2883Z Recombinant Zebrafish ACTL6B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACTL6B Related Research Area

ACTL6B involved in several pathways and played different roles in them. We selected most pathways ACTL6B participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Prostate Cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTL6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesKDM5A;PRMT7;KDM2A;VPS72;C20orf20;KDM2AA;MBD3B;KAT8;JMJD6
Chromatin organizationMSL3;CHD4;JADE1;GATAD2A;C20orf20;KDM6AL;TADA2A;KDM5B;PBRM1
Prostate CancerPDGFC;CREB5;PDGFRA;AKT2;RAF1;RB1;KRAS;SMARCA4;ACTL6B
RMTs methylate histone argininesSMARCC1B;ARID1A;SMARCE1;SMARCC1;SMARCB1B;WDR77;SMARCD3;ARID2;SMARCD3B

ACTL6B has several biochemical functions, for example, structural constituent of cytoskeleton, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTL6B itself. We selected most functions ACTL6B had, and list some proteins which have the same functions with ACTL6B. You can find most of the proteins on our site.

Function Related Protein
structural constituent of cytoskeletonKRT15;SPRR2A1;HIP1;NEFM;TUBA8L3;TUBG1;SPTB;CYLC2;GFAP
transcription coactivator activityMYSM1;PPARGC1A;HSF2;MED23;MED7;RXRA;GMEB2;PARK7;TFDP1

ACTL6B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTL6B here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTL6B.

SMARCA2; COQ9; TK1; ANXA7; CDKN1A; GSK3B; PLK1; CSNK2B; ATM; SMN1

  • Q&As
  • Reviews

Q&As (21)

Ask a question
Does ACTL6B have any known interacting partners outside the nBAF complex? 08/28/2022

While the main known interacting partners of ACTL6B are within the nBAF complex, additional interactions with other proteins or complexes have not been extensively characterized.

Is ACTL6B involved in any developmental processes? 06/30/2022

Yes, ACTL6B is implicated in neuronal development and differentiation, as it is required for proper chromatin remodeling during neuronal maturation.

What is the evolutionary conservation of ACTL6B? 06/25/2022

ACTL6B is evolutionarily conserved across different species, indicating its functional importance throughout evolution.

Are there any alternative splicing variants of ACTL6B? 02/09/2022

Alternative splicing variants of ACTL6B have not been widely reported in the literature. The majority of studies focus on the canonical isoform of ACTL6B.

Are there any known post-translational modifications of ACTL6B? 12/22/2021

Specific post-translational modifications of ACTL6B, such as phosphorylation or acetylation, have not been extensively studied.

What is the role of ACTL6B in recessive autism spectrum disorder (ASD)? 11/05/2021

ACTL6B loss is a significant cause of recessive ASD, suggesting its involvement in the development of this disorder.

What are the cellular functions of ACTL6B? 08/28/2021

ACTL6B plays a role in chromatin remodeling, gene regulation, and transcriptional control in various cell types, particularly in postmitotic neurons.

Is ACTL6B structurally similar to other actin-like proteins? 05/17/2021

Yes, ACTL6B shares structural similarities with other actin-like proteins, including the presence of an actin fold and conserved residues involved in protein-protein interactions.

What is the subcellular localization of ACTL6B? 03/24/2021

ACTL6B is primarily localized in the nucleus, where it exerts its functions in chromatin remodeling and gene regulation.

What are the functional roles of ACTL6B in cells? 04/15/2020

ACTL6B, as part of the nBAF complex, is involved in chromatin remodeling and gene regulation, particularly in postmitotic neurons. It plays a role in shaping the chromatin landscape and influencing cellular processes related to neuronal development and function.

What is the family of ACTL6B? 03/14/2020

ACTL6B belongs to the actin-like protein family, which comprises proteins that share structural similarities with actin but may have distinct functions and roles in cellular processes.

Are there any known homologs or paralogs of ACTL6B? 03/04/2020

Yes, ACTL6B has a paralog called ACTL6A (Actin-like 6A), which shares similarities in structure and function.

Are there any known genetic disorders associated with ACTL6B mutations? 05/15/2019

Currently, there are no specific genetic disorders linked to ACTL6B mutations

How does the nBAF complex contribute to chromatin remodeling? 04/02/2019

The nBAF complex, including ACTL6B, plays a role in modifying the structure of chromatin, allowing for proper gene regulation and functional changes in postmitotic neurons.

Which complex is ACTL6B a part of, and what is its function in neurons? 12/08/2018

ACTL6B is a component of the neuronal BRG1/brm-associated factor (nBAF) complex, which is required for chromatin remodeling specifically in postmitotic neurons.

 Can ACTL6B interact with other proteins or complexes? 09/13/2018

Yes, ACTL6B interacts with other proteins within the neuronal BRG1/brm-associated factor (nBAF) complex, including various subunits involved in chromatin remodeling and gene regulation.

Does ACTL6B have any known interacting partners outside the nBAF complex? 09/05/2018

While the main known interacting partners of ACTL6B are within the nBAF complex, additional interactions with other proteins or complexes have not been extensively characterized.

Are there potential implications for targeting ACTL6B or the nBAF complex in ASD treatment? 06/26/2018

Targeting ACTL6B or the nBAF complex could hold therapeutic potential for ASD; however, further research is needed to understand the precise mechanisms involved and to evaluate the feasibility and effectiveness of such targeting approaches.

 Is ACTL6B expressed in specific tissues or cell types? 05/01/2018

ACTL6B is widely expressed in various tissues, but its expression is particularly prominent in the brain, where it plays a crucial role in neuronal development and function.

What is the proposed mechanism by which ACTL6B contributes to ASD? 12/30/2017

Impaired neuron-specific chromatin repression is proposed as a potential mechanism underlying the association between ACTL6B loss and ASD.

What is the structure of ACTL6B? 05/29/2017

ACTL6B belongs to the actin-like protein family and has a conserved structure similar to actin proteins. It consists of a globular domain and a flexible C-terminal tail.

Customer Reviews (5)

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Reviews
06/29/2020

    Increased protein expression, enhanced cell proliferation, or inhibition of specific biological processes, when using this protein.

    02/08/2020

      The packaging includes proper labeling and documentation, facilitating easy identification and handling of the protein product upon arrival.

      10/07/2019

        They have provided valuable technical guidance and troubleshooting assistance, helping us optimize our experimental protocols and achieve better results.

        01/08/2018

          We have successfully replicated our findings using multiple batches of the protein product, indicating its reliable and consistent behavior.

          01/28/2017

            The protein product is produced using state-of-the-art manufacturing techniques, ensuring consistent quality and performance.

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