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Recombinant Mouse ACTL6B Protein

Cat.No. : ACTL6B-1245M
Product Overview : Recombinant Mouse ACTL6B full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Actl6b actin-like 6B [ Mus musculus ]
Official Symbol : ACTL6B
Gene ID : 83766
mRNA Refseq : NM_031404.4
Protein Refseq : NP_113581.1
MIM :
UniProt ID : Q99MR0

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (21)

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Does ACTL6B have any known interacting partners outside the nBAF complex? 08/28/2022

While the main known interacting partners of ACTL6B are within the nBAF complex, additional interactions with other proteins or complexes have not been extensively characterized.

Is ACTL6B involved in any developmental processes? 06/30/2022

Yes, ACTL6B is implicated in neuronal development and differentiation, as it is required for proper chromatin remodeling during neuronal maturation.

What is the evolutionary conservation of ACTL6B? 06/25/2022

ACTL6B is evolutionarily conserved across different species, indicating its functional importance throughout evolution.

Are there any alternative splicing variants of ACTL6B? 02/09/2022

Alternative splicing variants of ACTL6B have not been widely reported in the literature. The majority of studies focus on the canonical isoform of ACTL6B.

Are there any known post-translational modifications of ACTL6B? 12/22/2021

Specific post-translational modifications of ACTL6B, such as phosphorylation or acetylation, have not been extensively studied.

What is the role of ACTL6B in recessive autism spectrum disorder (ASD)? 11/05/2021

ACTL6B loss is a significant cause of recessive ASD, suggesting its involvement in the development of this disorder.

What are the cellular functions of ACTL6B? 08/28/2021

ACTL6B plays a role in chromatin remodeling, gene regulation, and transcriptional control in various cell types, particularly in postmitotic neurons.

Is ACTL6B structurally similar to other actin-like proteins? 05/17/2021

Yes, ACTL6B shares structural similarities with other actin-like proteins, including the presence of an actin fold and conserved residues involved in protein-protein interactions.

What is the subcellular localization of ACTL6B? 03/24/2021

ACTL6B is primarily localized in the nucleus, where it exerts its functions in chromatin remodeling and gene regulation.

What are the functional roles of ACTL6B in cells? 04/15/2020

ACTL6B, as part of the nBAF complex, is involved in chromatin remodeling and gene regulation, particularly in postmitotic neurons. It plays a role in shaping the chromatin landscape and influencing cellular processes related to neuronal development and function.

What is the family of ACTL6B? 03/14/2020

ACTL6B belongs to the actin-like protein family, which comprises proteins that share structural similarities with actin but may have distinct functions and roles in cellular processes.

Are there any known homologs or paralogs of ACTL6B? 03/04/2020

Yes, ACTL6B has a paralog called ACTL6A (Actin-like 6A), which shares similarities in structure and function.

Are there any known genetic disorders associated with ACTL6B mutations? 05/15/2019

Currently, there are no specific genetic disorders linked to ACTL6B mutations

How does the nBAF complex contribute to chromatin remodeling? 04/02/2019

The nBAF complex, including ACTL6B, plays a role in modifying the structure of chromatin, allowing for proper gene regulation and functional changes in postmitotic neurons.

Which complex is ACTL6B a part of, and what is its function in neurons? 12/08/2018

ACTL6B is a component of the neuronal BRG1/brm-associated factor (nBAF) complex, which is required for chromatin remodeling specifically in postmitotic neurons.

 Can ACTL6B interact with other proteins or complexes? 09/13/2018

Yes, ACTL6B interacts with other proteins within the neuronal BRG1/brm-associated factor (nBAF) complex, including various subunits involved in chromatin remodeling and gene regulation.

Does ACTL6B have any known interacting partners outside the nBAF complex? 09/05/2018

While the main known interacting partners of ACTL6B are within the nBAF complex, additional interactions with other proteins or complexes have not been extensively characterized.

Are there potential implications for targeting ACTL6B or the nBAF complex in ASD treatment? 06/26/2018

Targeting ACTL6B or the nBAF complex could hold therapeutic potential for ASD; however, further research is needed to understand the precise mechanisms involved and to evaluate the feasibility and effectiveness of such targeting approaches.

 Is ACTL6B expressed in specific tissues or cell types? 05/01/2018

ACTL6B is widely expressed in various tissues, but its expression is particularly prominent in the brain, where it plays a crucial role in neuronal development and function.

What is the proposed mechanism by which ACTL6B contributes to ASD? 12/30/2017

Impaired neuron-specific chromatin repression is proposed as a potential mechanism underlying the association between ACTL6B loss and ASD.

What is the structure of ACTL6B? 05/29/2017

ACTL6B belongs to the actin-like protein family and has a conserved structure similar to actin proteins. It consists of a globular domain and a flexible C-terminal tail.

Customer Reviews (5)

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Reviews
06/29/2020

    Increased protein expression, enhanced cell proliferation, or inhibition of specific biological processes, when using this protein.

    02/08/2020

      The packaging includes proper labeling and documentation, facilitating easy identification and handling of the protein product upon arrival.

      10/07/2019

        They have provided valuable technical guidance and troubleshooting assistance, helping us optimize our experimental protocols and achieve better results.

        01/08/2018

          We have successfully replicated our findings using multiple batches of the protein product, indicating its reliable and consistent behavior.

          01/28/2017

            The protein product is produced using state-of-the-art manufacturing techniques, ensuring consistent quality and performance.

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