ADAM8
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Official Full Name
ADAM metallopeptidase domain 8
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Overview
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009] -
Synonyms
ADAM8; ADAM metallopeptidase domain 8; MS2; CD156; CD156a; disintegrin and metalloproteinase domain-containing protein 8; cell surface antigen MS2; human leukocyte differentiation antigen; a disintegrin and metalloproteinase domain 8;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Cynomolgus Monkey
- Human
- Mouse
- Rhesus
- E.coli
- HEK293
- Human Cell
- Mammalian Cell
- Mammalian cells
- C
- His
- Fc
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ADAM8 Related Articles
- ADAM8 Related Research Area
ADAM8 involved in several pathways and played different roles in them. We selected most pathways ADAM8 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Degradation of the extracellular matrix | CTS7;MMP10;CTSB;MGC174152;CTRB1;ADAM9;MMP13;COL15A1B;BMP1B |
Extracellular matrix organization | BMP10;FAM49BA;CTRB1;MMP10;CTSLL;ADAMTS3;F11R.2;PCOLCEB;MGC174155 |
ADAM8 has several biochemical functions, for example, calcium ion binding, cell adhesion molecule binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM8 itself. We selected most functions ADAM8 had, and list some proteins which have the same functions with ADAM8. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | LCP1;NCL;NUCB2;PPP3R1B;CALN1;C1R;PADI2;HPGDS;TLL1 |
cell adhesion molecule binding | NRXN3;ITGB7;NPTN;TENM2;NLGN3;PVRL3B;POSTNB;NRXN2;SDCBP |
metalloendopeptidase activity | ADAM32;MMP14A;ADAM8;ECE1;MMP9;ADAMTS2;MMP1;MMP24;ADAM33 |
metallopeptidase activity | C6AST1;ADAMTS12;PAPPAA;PAPPAB;ADAM20;PSMD14;ADAM15;ECEL1;AMZ2 |
protein binding | MLANA;USF1;TOMM70A;NKD2;FHL3;LGR4;GTPBP2;POU2F3;ZNF543 |
protein self-association | PTH1R;TRP53;MDH2;SYP;NKX3;SLC9A3R1;ABCD3;AGXT;PROSAPIP1 |
zinc ion binding | PAPLNB;TRIP6;C6AST4;RNF146;IGHMBP2;MSRB3;MKRN3;SPG7;OAS1 |
ADAM8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM8.
FSTL3; FST
- Q&As
- Reviews
Q&As (14)
Ask a questionADAM8 is involved in various complex biological processes such as inflammation and osteoclastogenesis.
You can choose the product whose Cat.No. is ADAM8-086H.
ADAM8 cleaves important cell surface proteins, such as cytokines and growth factors.
We provide a variety of ADAM8 proteins, all of which are in stock except those that require custom production.
His has a smaller molecular weight and has less impact on protein activity.
No, ADAM8 can only be activated by removing the leading domain.
Propofol inhibits ADAM8 expression in pancreatic cancer cells.
Yes, you can first communicate with our experts about specific customization requirements.
The expression level of ADAM8 is usually low in normal tissues and is significantly increased in response to pathological stimuli.
Lead times for custom-manufactured recombinant proteins range from 5-9 weeks.
Yes, transcription factor SP1 binds to the promoter of ADAM8.
ADAM8 has two subtypes, the membrane type (ADAM8m) and the secretory type (ADAM8s).
ADAM8 is mainly used in the studies of breast, prostate and pancreatic cancers.
Yes, we will ship according to your specification after your purchase.
Customer Reviews (5)
Write a reviewThe ADAM8 protein received was of stable composition and high concentration, giving me satisfactory experimental results.
It is suitable for ELISA, and the help of technicians also made my experiments go smoothly.
The technician gave me a detailed introduction to the ADAM38 protein for the smooth running of the subsequent experiments.
The after-sales service of the product is guaranteed, which has helped me solve many problems in the experiment.
Good protein quality, good service attitude and affordable price.
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