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ADAM8

  • Official Full Name

    ADAM metallopeptidase domain 8

  • Overview

    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
  • Synonyms

    ADAM8; ADAM metallopeptidase domain 8; MS2; CD156; CD156a; disintegrin and metalloproteinase domain-containing protein 8; cell surface antigen MS2; human leukocyte differentiation antigen; a disintegrin and metalloproteinase domain 8;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADAM8-525H Active Recombinant Human ADAM Metallopeptidase Domain 8, His-tagged Mammalian cells His
Human ADAM8-615H Recombinant Human ADAM8 protein, His & T7-tagged E.coli His/T7 Ser371~Glu587 (Accession # P78325)
Human ADAM8-086H Recombinant Human ADAM8 Protein, His-tagged HEK293 His 824
Human ADAM8-004H Recombinant Human ADAM8 Protein, C-His-tagged E.coli C-His
Human ADAM8-355H Recombinant Human ADAM8 protein, His-tagged HEK293 His 481
Human ADAM8-2421H Recombinant Human ADAM8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ADAM8-2421H-B Recombinant Human ADAM8 Protein Pre-coupled Magnetic Beads HEK293
Human ADAM8-1094H Recombinant Human ADAM8 Protein (Glu145-Asn494), N-His tagged E.coli N-His Glu145-Asn494
Human ADAM8-3863H Recombinant Human ADAM8 Protein (Met1-Pro497), C-His tagged Mammalian cells C-His Met1-Pro497
Mouse Adam8-616M Recombinant Mouse Adam8 protein, His-tagged E.coli His Glu145~Cys493
Mouse ADAM8-1305M Recombinant Mouse ADAM8 Protein Mammalian Cell His
Mouse ADAM8-320M Recombinant Mouse ADAM8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ADAM8-320M-B Recombinant Mouse ADAM8 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey ADAM8-147C Recombinant Cynomolgus ADAM8, His tagged Human Cell Fc
Cynomolgus Monkey ADAM8-855CCL Recombinant Cynomolgus ADAM8 cell lysate Human Cell N/A
Rhesus ADAM8-615R Active Recombinant Rhesus ADAM8 protein, His-tagged HEK293 His Met1-Pro497
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADAM8 Related Articles
  • ADAM8 Related Research Area

ADAM8 involved in several pathways and played different roles in them. We selected most pathways ADAM8 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Degradation of the extracellular matrixCTS7;MMP10;CTSB;MGC174152;CTRB1;ADAM9;MMP13;COL15A1B;BMP1B
Extracellular matrix organizationBMP10;FAM49BA;CTRB1;MMP10;CTSLL;ADAMTS3;F11R.2;PCOLCEB;MGC174155

ADAM8 has several biochemical functions, for example, calcium ion binding, cell adhesion molecule binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM8 itself. We selected most functions ADAM8 had, and list some proteins which have the same functions with ADAM8. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingLCP1;NCL;NUCB2;PPP3R1B;CALN1;C1R;PADI2;HPGDS;TLL1
cell adhesion molecule bindingNRXN3;ITGB7;NPTN;TENM2;NLGN3;PVRL3B;POSTNB;NRXN2;SDCBP
metalloendopeptidase activityADAM32;MMP14A;ADAM8;ECE1;MMP9;ADAMTS2;MMP1;MMP24;ADAM33
metallopeptidase activityC6AST1;ADAMTS12;PAPPAA;PAPPAB;ADAM20;PSMD14;ADAM15;ECEL1;AMZ2
protein bindingMLANA;USF1;TOMM70A;NKD2;FHL3;LGR4;GTPBP2;POU2F3;ZNF543
protein self-associationPTH1R;TRP53;MDH2;SYP;NKX3;SLC9A3R1;ABCD3;AGXT;PROSAPIP1
zinc ion bindingPAPLNB;TRIP6;C6AST4;RNF146;IGHMBP2;MSRB3;MKRN3;SPG7;OAS1

ADAM8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM8.

FSTL3; FST

Li, SQ; Zhu, S; et al. Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury. JOURNAL OF TOXICOLOGICAL SCIENCES 39:339-351(2014).
Romagnoli, M; Mineva, ND; et al. ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. EMBO MOLECULAR MEDICINE 6:278-294(2014).
  • Q&As
  • Reviews

Q&As (14)

Ask a question
What physiological processes is ADAM8 involved in? 04/20/2023

ADAM8 is involved in various complex biological processes such as inflammation and osteoclastogenesis.

My research has relatively high requirements for protein purity. Do you provide high-purity ADAM8 in stock? 12/10/2022

You can choose the product whose Cat.No. is ADAM8-086H.

Can ADAM8 cleave proteins? 10/18/2022

ADAM8 cleaves important cell surface proteins, such as cytokines and growth factors.

Is the ADAM8 in stock? 10/12/2022

We provide a variety of ADAM8 proteins, all of which are in stock except those that require custom production.

Which of HIS and GST has less effect on ADAM8 protein? 03/14/2022

His has a smaller molecular weight and has less impact on protein activity.

Is the precursor ADAM8 protein form active? 09/05/2021

No, ADAM8 can only be activated by removing the leading domain.

Does propofol have an effect on the expression of ADAM8 in pancreatic cancer cells? 07/15/2021

Propofol inhibits ADAM8 expression in pancreatic cancer cells.

If I customize ADAM8 with special requirements, can I specify the expression system? 05/17/2021

Yes, you can first communicate with our experts about specific customization requirements.

What is the expression level of ADAM8 under normal conditions? 10/21/2020

The expression level of ADAM8 is usually low in normal tissues and is significantly increased in response to pathological stimuli.

How soon will the customized ADAM8 arrive? 09/29/2020

Lead times for custom-manufactured recombinant proteins range from 5-9 weeks.

Is SP1 combined with ADAM8? 06/24/2020

Yes, transcription factor SP1 binds to the promoter of ADAM8.

What are the two subtypes of ADAM8? 06/19/2020

ADAM8 has two subtypes, the membrane type (ADAM8m) and the secretory type (ADAM8s).

In which diseases is ADAM8 currently used in research? 06/17/2020

ADAM8 is mainly used in the studies of breast, prostate and pancreatic cancers.

Can I specify a product that has two product forms? 08/03/2019

Yes, we will ship according to your specification after your purchase.

Customer Reviews (5)

Write a review
Reviews
02/08/2022

    The ADAM8 protein received was of stable composition and high concentration, giving me satisfactory experimental results.

    06/22/2021

      It is suitable for ELISA, and the help of technicians also made my experiments go smoothly.

      06/09/2021

        The technician gave me a detailed introduction to the ADAM38 protein for the smooth running of the subsequent experiments.

        07/03/2020

          The after-sales service of the product is guaranteed, which has helped me solve many problems in the experiment.

          07/18/2019

            Good protein quality, good service attitude and affordable price.

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