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Recombinant Mouse Adam8 protein, His-tagged

Cat.No. : Adam8-616M
Product Overview : Recombinant Mouse Adam8 aa. (Glu145~Cys493) fused with N-terminal His tag was produced in E. coli cells.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants.
Source : E. coli
Species : Mouse
Tag : His
Form : Freeze-dried powder
Molecular Mass : 44kDa as determined by SDS-PAGE reducing conditions
Protein length : Glu145~Cys493
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.3.
Applications : Positive Control; Immunogen; SDS-PAGE; WB
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Concentration : 200µg/mL
Storage buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex
Gene Name : Adam8 a disintegrin and metallopeptidase domain 8 [ Mus musculus (house mouse) ]
Official Symbol : Adam8
Synonyms : Adam8; a disintegrin and metallopeptidase domain 8; MS2; CD156; ADAM 8; CD156a; E430039A18Rik; disintegrin and metalloproteinase domain-containing protein 8; a disintegrin and metalloprotease domain 8; cell surface antigen MS2; macrophage cysteine-rich glycoprotein
Gene ID : 11501
mRNA Refseq : NM_001291066.2
Protein Refseq : NP_001277995.1
UniProt ID : Q3U7G2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (14)

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What physiological processes is ADAM8 involved in? 04/20/2023

ADAM8 is involved in various complex biological processes such as inflammation and osteoclastogenesis.

My research has relatively high requirements for protein purity. Do you provide high-purity ADAM8 in stock? 12/10/2022

You can choose the product whose Cat.No. is ADAM8-086H.

Can ADAM8 cleave proteins? 10/18/2022

ADAM8 cleaves important cell surface proteins, such as cytokines and growth factors.

Is the ADAM8 in stock? 10/12/2022

We provide a variety of ADAM8 proteins, all of which are in stock except those that require custom production.

Which of HIS and GST has less effect on ADAM8 protein? 03/14/2022

His has a smaller molecular weight and has less impact on protein activity.

Is the precursor ADAM8 protein form active? 09/05/2021

No, ADAM8 can only be activated by removing the leading domain.

Does propofol have an effect on the expression of ADAM8 in pancreatic cancer cells? 07/15/2021

Propofol inhibits ADAM8 expression in pancreatic cancer cells.

If I customize ADAM8 with special requirements, can I specify the expression system? 05/17/2021

Yes, you can first communicate with our experts about specific customization requirements.

What is the expression level of ADAM8 under normal conditions? 10/21/2020

The expression level of ADAM8 is usually low in normal tissues and is significantly increased in response to pathological stimuli.

How soon will the customized ADAM8 arrive? 09/29/2020

Lead times for custom-manufactured recombinant proteins range from 5-9 weeks.

Is SP1 combined with ADAM8? 06/24/2020

Yes, transcription factor SP1 binds to the promoter of ADAM8.

What are the two subtypes of ADAM8? 06/19/2020

ADAM8 has two subtypes, the membrane type (ADAM8m) and the secretory type (ADAM8s).

In which diseases is ADAM8 currently used in research? 06/17/2020

ADAM8 is mainly used in the studies of breast, prostate and pancreatic cancers.

Can I specify a product that has two product forms? 08/03/2019

Yes, we will ship according to your specification after your purchase.

Customer Reviews (5)

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Reviews
02/08/2022

    The ADAM8 protein received was of stable composition and high concentration, giving me satisfactory experimental results.

    06/22/2021

      It is suitable for ELISA, and the help of technicians also made my experiments go smoothly.

      06/09/2021

        The technician gave me a detailed introduction to the ADAM38 protein for the smooth running of the subsequent experiments.

        07/03/2020

          The after-sales service of the product is guaranteed, which has helped me solve many problems in the experiment.

          07/18/2019

            Good protein quality, good service attitude and affordable price.

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