Active Recombinant Human ADAM Metallopeptidase Domain 8, His-tagged

• Cat.No.: ADAM8-525H
• Product Overview: Recombinant Human ADAM8protein was expressed in Murine myeloma cell line with a C-terminal 6-His tag.Met1-Pro497.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: His
• Protein Length: 1-497 a.a.
• Description: ADAM8, also known ascell surface antigen MS2 or CD156a, is a member of the ADAM family that containsa disintegrin and metalloproteaselike domain. ADAM8 can cleave a variety of substratesand has been shown as a sheddase for the low affinity IgE receptor CD23 andthe neural recognition molecule CHL1. Expression and regulation studiessuggest that ADAM8 is a novel osteoclast stimulating factor and may play arole in asthma.
• Form: Supplied as a 0.2 μmfiltered solution in Glycerol, Tris, NaCl and CaCl2.
• N-terminalSequence: Glu158
• Molecular Weight: 38 kDa
• Activity: Measuredby its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-DpaRSSSR-NH2,The specific activity is > 1 pmol/min/μg, as measured under the described conditions.
• Endotoxin Level: < 1.0 EU per 1 μgof the protein by the LAL method.
• SDS-PAGE: 42 kDa, reducingconditions.
• Purity: > 90%, by SDSPAGEunder reducing conditions and visualized by silver stain.
• Storage: Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt,-20 to -70°C as supplied. 3 months, -20 to -70°C under sterile conditionsafter opening.

Gene Information

• Gene Name: ADAM8 ADAM metallopeptidasedomain 8 [ Homo sapiens ]
• Official Symbol: ADAM8
• Synonyms: ADAM8; ADAMmetallopeptidase domain 8; MS2; CD156; CD156a; disintegrin andmetalloproteinase domain-containing protein 8; cell surface antigen MS2;human leukocyte differentiation antigen; a disintegrin and metalloproteinasedomain 8; EC 3.4.24.-
• Gene ID: 101
• mRNA Refseq: NM_001109
• Protein Refseq: NP_001100
• MIM: 602267
• UniProt ID: P78325
• Chromosome Location: 10q26.3
• Function: calcium ion binding;cell adhesion molecule binding; metalloendopeptidase activity;metallopeptidase activity; peptidase activity; protein binding; protein self-association;zinc ion binding