AHRR
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Official Full Name
aryl-hydrocarbon receptor repressor
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Overview
The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
AHRR; aryl-hydrocarbon receptor repressor; AHH, AHHR, aryl hydrocarbon receptor regulator; aryl hydrocarbon receptor repressor; bHLHe77; KIAA1234; AHH; AhR repressor; AHRR_HUMAN; aryl hydrocarbon hydroxylase regulator; aryl hydrocarbon receptor regulator; Arylhydrocarbon receptor repressor; Class E basic helix-loop-helix protein 77; Dioxin receptor repressor; MGC167813; MGC176630; OTTHUMP00000221488; OTTHUMP00000221489; AHHR;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | AHRR-3649H | Recombinant Human AHRR, His-tagged | E.Coli or Yeast | His | 701 |
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| Human | AHRR-466H | Recombinant Human AHSA1 Protein, GST-tagged | Wheat Germ | GST |
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| Human | AHRR-465H | Recombinant Human AHRR Protein, GST-tagged | Wheat Germ | GST |
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| Human | AHRR-950HF | Recombinant Full Length Human AHRR Protein, GST-tagged | In Vitro Cell Free System | GST | 719 amino acids |
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| Human | AHRR-1698H | Recombinant Human AHRR protein, His & GST-tagged | E.coli | His/GST | Met1~Pro182 (Accession # A9YTQ3) |
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| Mouse | AHRR-1444M | Recombinant Mouse AHRR Protein | Mammalian Cell | His |
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| Mouse | AHRR-406M-B | Recombinant Mouse AHRR Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | AHRR-406M | Recombinant Mouse AHRR Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | AHRR-573R | Recombinant Rat AHRR Protein | Mammalian Cell | His |
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| Rat | AHRR-229R | Recombinant Rat AHRR Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | AHRR-229R-B | Recombinant Rat AHRR Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | AHRR-4485C | Recombinant Chicken AHRR | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- AHRR Related Articles
AHRR involved in several pathways and played different roles in them. We selected most pathways AHRR participated on our site, such as AhR pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AHRR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AhR pathway | EGFR;CDKN1A;JUN;AHR;PTGES3;JUND;CDKN1B;AHRR;CYP1B1 |
AHRR has several biochemical functions, for example, DNA binding, protein dimerization activity, transcriptional repressor activity, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHRR itself. We selected most functions AHRR had, and list some proteins which have the same functions with AHRR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | C17orf49;DHX9;GTF2A1L;RTEL1;ZNF280D;PIAS4;PAX2B;SIX6A;SP9 |
| protein dimerization activity | ID2A;TFAP2A;POLR2C;TXLNB;MTOR;ASCL4;NCOA1;NUP210;SOHLH2 |
| transcriptional repressor activity, RNA polymerase II transcription factor binding | MINA;AHRRA;MLIP;AHRRB;CREBBP;ELP2;RIMKLB;PITX2;TBX6 |
AHRR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHRR here. Most of them are supplied by our site. Hope this information will be useful for your research of AHRR.
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- Q&As
- Reviews
Q&As (10)
Ask a questionGenetic variations in AHRR can lead to altered protein function and influence individual susceptibility to diseases influenced by the AHR signaling pathway, such as cancer and immune-related disorders.
AHRR expression can influence an individual's sensitivity to environmental carcinogens and toxicants by modulating AHR activity and downstream gene expression.
AHRR expression levels can vary among tissues and cell types, depending on the local microenvironment, exposure to specific ligands, and tissue-specific transcriptional regulators.
AHRR contains domains that enable its interaction with AHR, such as bHLH (basic helix-loop-helix) and PAS (Per-Arnt-Sim) domains, facilitating the formation of inhibitory complexes with AHR.
AHRR acts as a negative regulator of the AHR signaling pathway, inhibiting AHR-mediated gene transcription in response to ligand activation.
AHRR competes with AHR for binding to the same target genes, effectively blocking AHR-mediated transcription and inhibiting the expression of AHR-responsive genes.
AHRR is implicated in modulating inflammatory responses and immune cell differentiation, affecting the balance between pro-inflammatory and anti-inflammatory signals.
AHRR expression can be induced by various environmental stimuli, such as exposure to AHR ligands and other stressors. Transcription factors and epigenetic modifications can regulate AHRR gene expression.
AHRR plays a crucial role in regulating the expression of genes involved in xenobiotic metabolism and detoxification, contributing to the body's defense against environmental toxins.
AHRR is involved in circadian rhythm regulation and contributes to metabolic homeostasis by influencing the expression of clock genes and metabolic regulators.
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