AKR1B10
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Official Full Name
aldo-keto reductase family 1, member B10 (aldose reductase)
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Overview
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008] -
Synonyms
AKR1B10; aldo-keto reductase family 1, member B10 (aldose reductase); HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12; aldo-keto reductase family 1 member B10; ARP; hARP; SI reductase; aldose reductase-like 1; small intestine reductase; aldose reductase-like peptide; aldose reductase-related protein; aldo-keto reductase family 1, member B11 (aldose reductase-like);
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Sf21 Insect Cell
- Wheat Germ
- GST
- His
- T7
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | AKR1B10-406H | Active Recombinant Human AKR1B10 protein | E.coli | Non |
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| Human | AKR1B10-995H | Active Recombinant Human AKR1B10 Protein, Met & His-tagged | Sf21 Insect Cell | His | Ala2-Tyr316 |
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| Human | AKR1B10-2764H | Recombinant Human AKR1B10, His-tagged | E.coli | His |
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| Human | AKR1B10-27154TH | Recombinant Human AKR1B10 | E.coli | Non | 316 amino acids |
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| Human | AKR1B10-410H | Recombinant Human AKR1B10 Protein, GST-tagged | Wheat Germ | GST |
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| Human | AKR1B10-27155TH | Recombinant Human AKR1B10 | E.coli | Non |
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| Human | AKR1B10-8931HCL | Recombinant Human AKR1B10 293 Cell Lysate | HEK293 | Non |
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| Human | AKR1B10-1533H | Recombinant Human AKR1B10 protein, His & T7-tagged | E.coli | His&T7 | Met1~Tyr316 (Accession # O60218) |
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| Human | AKR1B10-0254H | Recombinant Human AKR1B10 Protein (M1-Y316), Tag Free | E.coli | Non | M1-Y316 |
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| Human | AKR1B10-301110H | Recombinant Human AKR1B10 protein, GST-tagged | E.coli | GST | Met1-Tyr316 |
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| Human | AKR1B10-0255H | Recombinant Human AKR1B10 Protein (M1-Y316), His tagged | E.coli | His | M1-Y316 |
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| Human | AKR1B10-1365HF | Recombinant Full Length Human AKR1B10 Protein, GST-tagged | In Vitro Cell Free System | GST | 316 amino acids |
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| Human | AKR1B10-0093H | Recombinant Human AKR1B10 Protein (Met1-Tyr316), N-His-tagged | E.coli | His | Met1-Tyr316 |
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| Chicken | AKR1B10-6197C | Recombinant Chicken AKR1B10 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
AKR1B10 involved in several pathways and played different roles in them. We selected most pathways AKR1B10 participated on our site, such as Pentose and glucuronate interconversions, Fructose and mannose metabolism, Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1B10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pentose and glucuronate interconversions | AKR1B8;UGT2B7;UGT1A4;UGT1A9;DHDHL;RPE;XYLB;AKR1A1A;DCXR |
| Fructose and mannose metabolism | TIGARB;PFKM;DHRS13L1;AKR1B1L;PFKMA;PFKP;TPI1B;FBP1;PFKFB1 |
| Galactose metabolism | AKR1B8;PFKM;PGM1;GLA;UGP2A;LCT;G6PCA.2;B4GALT1;GALM |
| Glycerolipid metabolism | AGPAT6;STIL;LIPCA;LPL;AGK;DGKAA;TAE1;ALDH2.1;MOGAT3 |
| Metabolic pathways | AGXTA;CYP2P10;NFS1;HYKK;TPH1A;HGD;GALNT10;NT5C1B;ATP6V1F |
AKR1B10 has several biochemical functions, for example, aldo-keto reductase (NADP) activity, geranylgeranyl reductase activity, indanol dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1B10 itself. We selected most functions AKR1B10 had, and list some proteins which have the same functions with AKR1B10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aldo-keto reductase (NADP) activity | SDR42E1;AKR1C3;H2-KE6;AKR1B10;MIOX;AKR1C21;HSD11B1LA;HSD3B5;AKR7A3 |
| geranylgeranyl reductase activity | AKR1B10;AKR1B8;AKR1C3 |
| indanol dehydrogenase activity | AKR1B10;AKR1B8;AKR1C3 |
| protein binding | PGR;PROP1;CD177;TNFSF14;CD200R3;PBX2;PUS7L;HFE2;PPARD |
| retinal dehydrogenase activity | AKR1C6;AKR1C3;ALDH1A3;ALDH8A1;ALDH1A1;AKR1B8;AKR1B10;Aldh1a7;AKR1C4 |
AKR1B10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1B10 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1B10.
ACACA; TERF2IP; Nedd1; Jup; Slain1; TSNAX
- Reviews
- Q&As
Customer Reviews (4)
Write a reviewHas therapeutic effects on specific disease models and is a promising candidate for new drugs.
The laboratory personnel feedback that the protein is easy to operate, can meet the experimental needs, and has a good cost performance.
It has been found to increase yield and purity and improve production efficiency in biotechnology production.
Good fluorescence labeling performance in light microscopy technology, which is helpful for cell imaging studies.
Q&As (15)
Ask a questionAKR1B10 protein is mainly detected in laboratory by enzyme-linked immunosorbent assay, fluorescence quantitative PCR and other methods.
AKR1B10 is involved in a variety of cell signaling pathways, such as NF-κB, WNT/ β-catenin signaling pathways, and thus plays a role in cell proliferation, differentiation and apoptosis.
This protein is involved in the NADP/NADPH metabolic pathway, plays an antioxidant and neuroprotective role, and thus has a promising application in the prevention and treatment of central nervous system diseases.
AKR1B10 has a certain application prospect in the early diagnosis and prognosis evaluation of lung cancer, colorectal cancer, liver cancer and other cancers.
The AKR1B10 protein is an alcohol contraction enzyme that is associated with a variety of diseases and is mainly found in tissues such as liver, lung, stomach, breast, kidney, pancreas and intestine.
AKR1B10 inhibitors can be used to prevent and treat a variety of inflammatory diseases, such as rheumatoid arthritis and hepatitis B.
AKR1B10 protein is associated with cell proliferation, angiogenesis and malignant metastasis in lung cancer
AKR1B10 inhibitors have potential anti-tumor and anti-inflammatory therapeutic effects and can be used in the treatment of lung cancer, breast cancer, diabetes and other diseases.
The expression level of AKR1B10 protein in tumor cells is increased, which is related to tumor proliferation, invasion and metastasis, and is a new tumor biomarker.
AKR1B10 is involved in the occurrence and development of metabolic diseases, such as diabetes and obesity, and is a possible therapeutic target.
AKR1B10 protein is involved in various metabolic processes and cell proliferation and growth, such as steroid hormone metabolism, fatty acid synthesis, cell cycle regulation and so on.
The metabolic pathways of steroid hormones involved in AKR1B10 include oxidative metabolism and reductive metabolism of steroid hormones.
AKR1B10 protein is involved in the metabolism of some drugs and may be related to hepatotoxicity, which is a hot molecule in the study of drug metabolism and toxicity.
AKR1B10 protein is associated with a variety of diseases, such as tumors, lung diseases, metabolic diseases, and neurological diseases.
AKR1B10 protein is involved in the metabolism of retinal glycoglycation end products, which is associated with diabetic retinopathy and other diseases.
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