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  • Official Full Name
  • anaplastic lymphoma receptor tyrosine kinase
  • Background
  • This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).
  • Synonyms
  • Alk; ALK tyrosine kinase receptor; ALK Tyrosine Kinase Receptor Precursor; ALK/EML4 fusion gene, included; ALK/NPM1 fusion gene, included; ALK_HUMAN; anaplastic lymphoma kinase (Ki-1); Anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; CD246; CD246 Antigen; EC 2.7.10.1; Ki 1; Ki1; NBLST3; Tcrz; TFG/ALK
Cat.#:Alk-15MTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Alk Protein
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Cat.#:ALK-16MTag:
Source (Host):HEK293Species:Macaca nemestrina
Product nameRecombinant Macaca nemestrina ALK Protein
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Cat.#:ALK-26499THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALK
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Cat.#:ALK-01HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALK (aa1060-1620), His-tagged
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Cat.#:ALK-08HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ALK, GST-tagged
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Cat.#:ALK-09HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ALK, MYC/DDK-tagged
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Cat.#:ALK-10HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK, His-tagged
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Cat.#:ALK-12HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK, GST-tagged
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Cat.#:ALK-13HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (F1174S), GST-tagged
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Cat.#:ALK-14HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (L1196M), GST-tagged
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Cat.#:ALK-15HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (S1206R), GST-tagged
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Cat.#:ALK-27HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (T1151_L1152insT), GST-tagged
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Cat.#:ALK-28HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (F1174L), GST-tagged
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Cat.#:ALK-29HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (G1202R), GST-tagged
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Cat.#:ALK-30HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (G1269S), GST-tagged
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Cat.#:ALK-31HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (R1275Q), GST-tagged
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Cat.#:ALK-32HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human ALK protein, Flag-tagged, Biotinylated
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Cat.#:ALK-33HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human ALK(L1196M) protein, Flag-tagged, Biotinylated
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Cat.#:ALK-385HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human ALK Protein, DDK/His-tagged
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Cat.#:ALK-469HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ALK Protein, GST-tagged
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Cat.#:ALK-471HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ALK Protein, GST-His tagged
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Cat.#:ALK-473HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALK Protein, GST-tagged
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Cat.#:ALK-49HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (T1151M), GST-tagged
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Cat.#:ALK-50HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (L1152R), GST-tagged
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Cat.#:ALK-51HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (G1269A), GST-tagged
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Cat.#:ALK-58HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ALK (C1156Y), GST-tagged
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Cat.#:ALK-65HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Anaplastic Lymphoma Receptor Tyrosine Kinase
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Cat.#:ALK-89HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ALK, His Tag
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Cat.#:ALK-92HTag:GST/His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ALK, GST-His Tag
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Cat.#:ALK-1552MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALK Protein
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Cat.#:Alk-3270MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Alk, His-tagged
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Cat.#:ALK-1625RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ALK Protein
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Cat.#:ALK-1626RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ALK Protein, hIgG1-tagged
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Cat.#:ALK-1627RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ALK Protein, hIgG4-tagged
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Cat.#:CSC-P0485Tag:
Source (Host):Species:Human
Product nameAnti-Human ALK MAb Stable Cell Line-CHO
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Cat.#:CSC-P0486Tag:
Source (Host):Species:Human
Product nameAnti-Human ALK F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0487Tag:
Source (Host):Species:Human
Product nameAnti-Human ALK scFv Stable Cell Line-CHO
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ALK Related Articles

Ziegler, JU; Schweiggert, RM; et al. A method for the simultaneous extraction and quantitation of lipophilic antioxidants in Triticum sp by HPLC-DAD/FLD-MSn. JOURNAL OF FOOD COMPOSITION AND ANALYSIS 39:94-102(2015).
Ishibashi, Y; Miyoshi, H; et al. Anaplastic lymphoma kinase protein expression, genetic abnormalities, and phosphorylation in soft tissue tumors: Phosphorylation is associated with recurrent metastasis. ONCOLOGY REPORTS 33:1667-1674(2015).