alk

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alk

Official Full Name anaplastic lymphoma receptor tyrosine kinase
Background This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).
Synonyms Alk; ALK tyrosine kinase receptor; ALK Tyrosine Kinase Receptor Precursor; ALK/EML4 fusion gene, included; ALK/NPM1 fusion gene, included; ALK_HUMAN; anaplastic lymphoma kinase (Ki-1); Anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; CD246; CD246 Antigen; EC 2.7.10.1; Ki 1; Ki1; NBLST3; Tcrz; TFG/ALK
    • Species :
    • Human
    • Macaca nemestrina
    • Mouse
    • Rhesus monkey
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • Flag
    • GST
    • hIgG1
    • hIgG4
    • MYC/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALK-01H Recombinant Human ALK Protein, GST-tagged Insect Cell GST
    Human ALK-08H Recombinant Human ALK, GST-tagged Sf21 Insect Cell GST
    Human ALK-09H Recombinant Human ALK, MYC/DDK-tagged HEK293 Myc/DDK
    Human ALK-10H Recombinant Human ALK, His-tagged Sf9 Insect Cell His
    Human ALK-1272H Recombinant Human ALK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ALK-12H Recombinant Human ALK, GST-tagged Sf9 Insect Cell GST
    Human ALK-13H Recombinant Human ALK (F1174S), GST-tagged Sf9 Insect Cell GST
    Human ALK-14H Recombinant Human ALK (L1196M), GST-tagged Sf9 Insect Cell GST
    Human ALK-15H Recombinant Human ALK (S1206R), GST-tagged Sf9 Insect Cell GST
    Human ALK-26499TH Recombinant Human ALK E.coli N/A
    Human ALK-26H Recombinant Human ALK protein, His-tagged E.coli His
    Human ALK-27H Recombinant Human ALK (T1151_L1152insT), GST-tagged Sf9 Insect Cell GST
    Human ALK-28H Recombinant Human ALK (F1174L), GST-tagged Sf9 Insect Cell GST
    Human ALK-29H Recombinant Human ALK (G1202R), GST-tagged Sf9 Insect Cell GST
    Human ALK-30H Recombinant Human ALK (G1269S), GST-tagged Sf9 Insect Cell GST
    Human ALK-31H Recombinant Human ALK (R1275Q), GST-tagged Sf9 Insect Cell GST
    Human ALK-32H Recombinant Human ALK protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human ALK-33H Recombinant Human ALK(L1196M) protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human ALK-385H Recombinant Human ALK Protein, DDK/His-tagged HEK293 DDK/His
    Human ALK-469H Recombinant Human ALK Protein, GST-tagged Insect Cell GST
    Human ALK-471H Recombinant Human ALK Protein, GST-His tagged Insect Cell GST/His
    Human ALK-473H Recombinant Human ALK Protein, GST-tagged Wheat Germ GST
    Human ALK-49H Recombinant Human ALK (T1151M), GST-tagged Sf9 Insect Cell GST
    Human ALK-50H Recombinant Human ALK (L1152R), GST-tagged Sf9 Insect Cell GST
    Human ALK-51H Recombinant Human ALK (G1269A), GST-tagged Sf9 Insect Cell GST
    Human ALK-58H Recombinant Human ALK (C1156Y), GST-tagged Sf9 Insect Cell GST
    Human ALK-65H Recombinant Human Anaplastic Lymphoma Receptor Tyrosine Kinase E.coli N/A
    Human ALK-89H Recombinant Human ALK, His Tag Sf9 Insect Cell His
    Human ALK-92H Recombinant Human ALK, GST-His Tag Sf9 Insect Cell GST/His
    Mouse ALK-1552M Recombinant Mouse ALK Protein Mammalian Cell His
    Mouse Alk-15M Recombinant Mouse Alk Protein HEK293 N/A
    Mouse Alk-3270M Recombinant Mouse Alk, His-tagged E.Coli or Yeast His
    Mouse Alk-577M Recombinant Mouse Alk Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rhesus monkey ALK-1625R Recombinant Rhesus Monkey ALK Protein HEK293 N/A
    Rhesus monkey ALK-1626R Recombinant Rhesus Monkey ALK Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey ALK-1627R Recombinant Rhesus Monkey ALK Protein, hIgG4-tagged HEK293 hIgG4
    Macaca nemestrina ALK-16M Recombinant Macaca nemestrina ALK Protein HEK293 N/A

    alk involved in several pathways and played different roles in them. We selected most pathways alk participated on our site, such as Non-small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with alk were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Non-small cell lung cancer RASSF1; PLCG1; MAPK3; BAD; RXRA; RAF1; PDPK1; ALK; RASSF5; SOS1

    alk has several biochemical functions, for example, ATP binding, NF-kappaB-inducing kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by alk itself. We selected most functions alk had, and list some proteins which have the same functions with alk. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ATP2A1L; IFIH1; PCXA; UBE2NB; NME2; STK25B; MAP3K9; POMK; OXSR1A; VARS
    NF-kappaB-inducing kinase activity IKBKE; ALPK2; RIPK3; IRAK1; ALK; MAP3K14; PPP4C
    identical protein binding CAD; UBQLN1; SP100; C1QTNF6; C1QL2; THG1L; NOL3; STAT2; GSTM3; UBE4A
    protein binding ANKRA2; SUMO1; SSSCA1; C5orf13; GFM1; FOXO3; COLGALT2; CCDC109A; SH3PXD2A; CHIC2
    protein tyrosine kinase activity DYRK3; RET; FGFR3; AXL; SHC1; EPHB2B; ERBB4; PDGFRB; ABL1; BCR
    transmembrane receptor protein tyrosine kinase activity NPTNB; FGFR1B; IGF1RB; MERTK; INSRA; MUSK; EPHA4A; EPHA2A; EK1; TRIM27

    alk has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with alk here. Most of them are supplied by our site. Hope this information will be useful for your research of alk.

    crizotinib; ch5424802; PTPRZ1; HSP90AB1; EPHA1; EIF4B

    Ziegler, JU; Schweiggert, RM; et al. A method for the simultaneous extraction and quantitation of lipophilic antioxidants in Triticum sp by HPLC-DAD/FLD-MSn. JOURNAL OF FOOD COMPOSITION AND ANALYSIS 39:94-102(2015).
    Ishibashi, Y; Miyoshi, H; et al. Anaplastic lymphoma kinase protein expression, genetic abnormalities, and phosphorylation in soft tissue tumors: Phosphorylation is associated with recurrent metastasis. ONCOLOGY REPORTS 33:1667-1674(2015).

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