AMACR
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Official Full Name
alpha-methylacyl-CoA racemase
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Overview
P504S is an enzyme involved in the β-oxidation of branched-chain fatty acids. Expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It has also been found to stain premalignant lesions of the prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN. It may be useful to confirm the diagnosis of small foci of prostate carcinoma in needle biopsies. P504S stains the majority prostate cancer, however, P504S has been shown to stain many other types of carcinoma such as hepatoma, breast carcinoma, pancreatic islet tumor and desmoplastic small round cell tumor (Miller and Tacha)1. HMW CK and p63 may serve as a useful panel. -
Synonyms
AMACR; alpha-methylacyl-CoA racemase; RM; RACE; CBAS4; AMACRD; 2-methylacyl-CoA racemase; OTTHUMP00000115916; OTTHUMP00000115917; OTTHUMP00000219978; TTHUMP00000219979; TTHUMP00000219980; EC 5.1.99.4; P504S;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- human
- Human
- Mouse
- Rhesus Macaque
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- N/A
- Wheat Germ
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
AMACR involved in several pathways and played different roles in them. We selected most pathways AMACR participated on our site, such as Primary bile acid biosynthesis, Metabolic pathways, Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMACR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Primary bile acid biosynthesis | CH25H;CYP8B1;HSD3B7;CYP39A1;CYP46A1.3;SLC27A5;SCP2;BRSK2;CYP46A1.1 |
| Metabolic pathways | RDH10B;PGAM1B;AKR1B8;PIK3C2G;PPCS;NADKA;FUT4;PIP5K1AB;PAFAH1B1A |
| Peroxisome | ABCD3A;DECR2;PEX11C;ACSL5;PEX13;PEX12;MLYCD;SLC25A17;PEX3 |
AMACR has several biochemical functions, for example, alpha-methylacyl-CoA racemase activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMACR itself. We selected most functions AMACR had, and list some proteins which have the same functions with AMACR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-methylacyl-CoA racemase activity | |
| receptor binding | TYROBP;PPP2R4;PTK6B;UCN2;CD276;AGXT;IFNL3;TNFSF12;NSG1 |
AMACR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMACR here. Most of them are supplied by our site. Hope this information will be useful for your research of AMACR.
Research Area
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