AMHR2
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Official Full Name
anti-Mullerian hormone receptor, type II
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Overview
This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
AMHR2; anti-Mullerian hormone receptor, type II; anti-Muellerian hormone type-2 receptor; MISR2; MISRII; M?llerian inhibiting substance type II receptor; AMH type II receptor; AMHR2_HUMAN; Anti-Muellerian hormone type II receptor; MGC141312; MIS type II receptor; MRII; Muellerian hormone type 2 receptor; Muellerian hormone type II receptor; Mullerian hormone receptor type II; OTTHUMP00000242707; OTTHUMP00000242708; OTTHUMP00000242709; Mullerian inhibiting substance type II receptor; AMHR;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus
- Human
- Mouse
- Rat
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Fc
- Flag
- His
- His (Fc)
- Avi
- MYC
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
AMHR2 involved in several pathways and played different roles in them. We selected most pathways AMHR2 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMHR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CXCL14;Ifna15;IFNG;CCL4;CXCL11;IL22RA2;GM13306;CCR8L;IFNE |
| TGF-beta signaling pathway | SMAD1;ACVR2AA;BMPR1BA;ACVR1;RPS6KB1;THBS1;AMHR2;BAMBIA;BMP7B |
AMHR2 has several biochemical functions, for example, ATP binding, anti-Mullerian hormone receptor activity, hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMHR2 itself. We selected most functions AMHR2 had, and list some proteins which have the same functions with AMHR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PIK3C2A;TNK2;MKI67;PFKMB;SNRK;GUCY2E;CCT3;KDRL;PSMC3 |
| anti-Mullerian hormone receptor activity | |
| hormone binding | NPR3;AMHR2;GPR30;NPR2;TTR;ADIPOR2;ADIPOR1A;UCN2;NPR1 |
| metal ion binding | TSSK5;UQCRFS1;ZNF557;BTY;AIFM3;PGGT1B;SLC8A1;ZNF69;ADH8A |
| protein binding | KLHL22;TSR2;CD97;CRLF1;TRIM17;OTX2;BCKDK;FUT11;GDI1 |
| receptor activity | CCR6;NLGN3;MED12;NLGN4B;ITGB1A;F2RL1;MED13;TIGIT;GRIA2A |
| receptor signaling protein serine/threonine kinase activity | SLKA;NEK4;OXSR1B;PAK2B;AMHR2;STK24A;TGFBR1;SBK3;BMPR1A |
| transforming growth factor beta receptor activity, type II | AMHR2;TGFBR2 |
AMHR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMHR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AMHR2.
HSP90AB1; HSP90AA1; CDC37; Hacd3
- Q&As
- Reviews
Q&As (10)
Ask a questionAMHR2 is involved in the development and maintenance of male and female reproductive organs, including the testes, ovaries, and genital ducts.
Mutations or dysregulation of AMHR2 can lead to reproductive abnormalities, such as persistent M眉llerian duct syndrome or disorders of sexual development.
AMHR2 plays a crucial role in mediating the AMH-induced regression of M眉llerian ducts in male embryos, allowing for the development of the male reproductive system.
Besides its role in the reproductive system, AMHR2 may have additional functions in non-reproductive tissues or diseases, highlighting its potential as a therapeutic target beyond reproduction.
AMHR2 signaling pathways may cross-talk with other signaling pathways, such as the Wnt/尾-catenin or Notch pathways, to fine-tune reproductive processes and organ development.
AMHR2 expression can be influenced by genetic variations and epigenetic modifications that contribute to inter-individual differences in AMHR2 levels.
AMHR2 forms a complex with AMH ligand and the co-receptor, AMH receptor type 2 (ACVR2A), to initiate signaling cascades.
AMHR2 expression is regulated by various factors during embryonic development and tissue-specific differentiation, including transcription factors and hormonal cues.
Modulating AMHR2 signaling pathways may hold therapeutic potential for managing reproductive disorders characterized by abnormal M眉llerian duct development or function.
AMHR2 activates the Smad signaling pathway, leading to downstream gene expression changes involved in reproductive organ development and maintenance.
Customer Reviews (3)
Write a reviewReliable detection of protein-protein interaction dynamics.
Accurate determination of protein complex composition.
Compatibility with challenging sample types (e.g., crude extracts).
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