Active Recombinant Human AMHR2, Fc-tagged, Biotinylated
|Product Overview :||The recombinant human AMHR2-Fc fusion protein is expressed as a 354 amino acid protein consisting of Pro18 - Ser144 region of AMHR2 (UniProt accession #Q16671) and a C-terminal Fc fusion from human IgG1, which exists as a dimer under non-reducing condition.|
- Gene Information
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|Source :||Human cells|
|Form :||Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).|
|Bio-activity :||Recombinant AMHR2 protein binds human AMH/MIS and blocks AMH/MIS-induced signaling activity|
|Molecular Mass :||Calculated molecular mass (kDa): 39.0; Estimated by SDS-PAGE under reducing condition (kDa): 50-55|
|AA Sequence :||PPNRRTCVFFEAPGVRGSTKTLGEL LDTGTELPRAIRCLYSRCCFGIWNL TQDRAQVEMQGCRDSDEPGCESLH CDPSPRAHPSPGSTLFTCSCGTDFC NANYSHLPPPGSPGTPGSQGPQAAP GESTGTHTCPPCPAPELLGGPSVF LFPPKPKDTLMISRTPEVTCVVVDV SHEDPEVKFNWYVDGVEVHNAKTKP REEQYNSTYRVVSVLTVLHQDWLN GKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSL TCLVKGFYPSDIAVEWESNGQPE NNYKTTPPVLDSDGSFFLYSKLTVD KSRWQQGNVFSCSVMHEALHNHYTQ KSLSLSPGK|
|Endotoxin :||<0.1 eu per 1 μg of purified recombinant protein determined by the|
|Purity :||>95% judged by SDS-PAGE under reducing condition|
|Storage :||The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.|
|Gene Name :||AMHR2 anti-Mullerian hormone receptor, type II [ Homo sapiens ]|
|Official Symbol :||AMHR2|
|Synonyms :||AMHR2; anti-Mullerian hormone receptor, type II; anti-Muellerian hormone type-2 receptor; MISR2; MISRII; M?llerian inhibiting substance type II receptor; AMH type II receptor; MIS type II receptor; anti-Muellerian hormone type II receptor; Mullerian inhibiting substance type II receptor; AMHR; MRII;|
|Gene ID :||269|
|mRNA Refseq :||NM_001164690|
|Protein Refseq :||NP_001158162|
|UniProt ID :||Q16671|
|Chromosome Location :||12q13|
|Pathway :||ALK2 signaling events, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem;|
|Function :||ATP binding; hormone binding; metal ion binding; nucleotide binding; receptor activity; transforming growth factor beta receptor activity, type II;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
AMHR2 is involved in the development and maintenance of male and female reproductive organs, including the testes, ovaries, and genital ducts.
Mutations or dysregulation of AMHR2 can lead to reproductive abnormalities, such as persistent M眉llerian duct syndrome or disorders of sexual development.
AMHR2 plays a crucial role in mediating the AMH-induced regression of M眉llerian ducts in male embryos, allowing for the development of the male reproductive system.
Besides its role in the reproductive system, AMHR2 may have additional functions in non-reproductive tissues or diseases, highlighting its potential as a therapeutic target beyond reproduction.
AMHR2 signaling pathways may cross-talk with other signaling pathways, such as the Wnt/尾-catenin or Notch pathways, to fine-tune reproductive processes and organ development.
AMHR2 expression can be influenced by genetic variations and epigenetic modifications that contribute to inter-individual differences in AMHR2 levels.
AMHR2 forms a complex with AMH ligand and the co-receptor, AMH receptor type 2 (ACVR2A), to initiate signaling cascades.
AMHR2 expression is regulated by various factors during embryonic development and tissue-specific differentiation, including transcription factors and hormonal cues.
Modulating AMHR2 signaling pathways may hold therapeutic potential for managing reproductive disorders characterized by abnormal M眉llerian duct development or function.
AMHR2 activates the Smad signaling pathway, leading to downstream gene expression changes involved in reproductive organ development and maintenance.
Customer Reviews (3)Write a review
Reliable detection of protein-protein interaction dynamics. -
Accurate determination of protein complex composition. -
Compatibility with challenging sample types (e.g., crude extracts). -
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