Recombinant Rat Areg, His-tagged
Cat.No. : | Areg-3433R |
Product Overview : | Amphiregulin (Areg) |
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Description : | may act as a growth factor during central nervous system development . |
Source : | E. Coli or Yeast |
Species : | Rat |
Tag : | His |
Form : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Protein length : | 243 |
Purity : | >90% |
Notes : | Small volumes of Areg recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. For extended storage, store at -20 or -80 degree C. |
Storage Buffer : | PBS pH 7.4, 50% glycerol |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | Areg amphiregulin [ Rattus norvegicus ] |
Official Symbol : | Areg |
Synonyms : | AREG; amphiregulin; AR; SDGF; schwannoma-derived growth factor; |
Gene ID : | 29183 |
mRNA Refseq : | NM_017123 |
Protein Refseq : | NP_058819 |
Pathway : | ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; |
Function : | cytokine activity; epidermal growth factor receptor binding; growth factor activity; |
Products Types
◆ Recombinant Protein | ||
AREG-402R | Recombinant Rat AREG Protein, His (Fc)-Avi-tagged | +Inquiry |
AREG-002H | Active Recombinant Human AREG Protein | +Inquiry |
Areg-242M | Recombinant Mouse Areg Protein, His-tagged | +Inquiry |
AREG-02H | Active Recombinant Human AREG Protein | +Inquiry |
AREG-195A | Active Recombinant Human AREG Protein | +Inquiry |
◆ Lysates | ||
AREG-8762HCL | Recombinant Human AREG 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (8)
Write a reviewThe high-quality AREG protein available from reliable manufacturers ensures accurate detection and quantification of ANO4 protein levels in samples, providing valuable insights into its biological roles and signaling pathways.
In WB experiments, AREG protein exhibits exceptional performance, making it an ideal tool for studying ANO4 protein expression, regulation, and potential functional changes.
AREG protein demonstrates great utility in protein electron microscopy structure analysis.
Its remarkable specificity and functionality have allowed me to investigate various cellular processes with precision and confidence.
the manufacturer's support has been instrumental in assisting me throughout my work with the AREG protein.
Its exceptional quality ensures accurate data and supports the validity of my research findings.
the high-quality AREG protein is available in various forms, including recombinant proteins and purified samples, enabling researchers to select the most suitable format for their specific experimental setup.
The technical team's expertise and promptness in addressing any queries or concerns have been extraordinary.
Q&As (34)
Ask a questionYes, AREG is implicated in various inflammatory diseases, such as asthma and inflammatory bowel disease, where it can modulate immune responses and contribute to tissue inflammation.
AREG can be released from cells through multiple mechanisms, such as proteolytic cleavage by metalloproteases, exocytosis, and shedding of its precursor form.
Yes, dysregulation of AREG has been linked to various diseases, including cancer, inflammatory disorders, and certain gastrointestinal conditions.
AREG plays a critical role in wound healing by promoting cell migration, proliferation, and tissue regeneration, particularly in epithelial tissues.
AREG has been identified as a potential therapeutic target in cancer treatment due to its involvement in promoting cancer cell growth and survival. However, further research is needed to explore its clinical utility.
AREG can promote cancer cell proliferation by binding to the EGFR and activating downstream signaling pathways that drive cell cycle progression and survival.
Yes, AREG has been shown to promote angiogenesis, the formation of new blood vessels, by stimulating endothelial cell proliferation and migration.
There is limited research suggesting that AREG may have a role in neurodegenerative diseases. Some studies have shown altered AREG expression in conditions like Alzheimer's disease and Parkinson's disease, but more research is needed to fully understand its significance in these diseases.
Blocking AREG signaling may lead to potential side effects, as AREG is involved in various physiological processes. However, the specific side effects would depend on the context and the therapeutic approach used.
Currently, there are no approved therapies specifically targeting AREG, but there are ongoing clinical trials investigating the efficacy of targeting AREG and its associated pathways in different diseases.
There are ongoing clinical trials investigating the potential use of inhibitors and antibodies targeting AREG in cancer treatment. These trials aim to evaluate the safety and efficacy of AREG-targeted therapies alone or in combination with other treatments.
Yes, AREG is implicated in various neurological processes, including neuroprotection, neural development, and synaptic plasticity.
Yes, AREG can be produced by various cell types, including epithelial cells, fibroblasts, immune cells, and endothelial cells. Its production can be stimulated by different factors depending on the cell type and the physiological context.
AREG plays a crucial role in mammary gland development and lactation by promoting the growth and differentiation of mammary epithelial cells, as well as stimulating milk production.
Yes, the expression of AREG can be regulated by hormones, such as estrogens and progesterone, in various target tissues.
AREG expression levels have been investigated as potential biomarkers for certain cancers, including colorectal, breast, and ovarian cancer, as well as inflammatory bowel disease.
Yes, AREG can influence cell differentiation in certain contexts. It has been shown to promote the differentiation of various cell types, including mammary epithelial cells, neuronal progenitor cells, and keratinocytes.
There is evidence suggesting that AREG can promote metastasis in certain types of cancer. It may contribute to the invasive and migratory properties of cancer cells, aiding their spread to distant organs.
The AREG protein can be activated by various signals, including growth factors, cytokines, and cell-cell interactions.
Yes, AREG protein research is also emerging in fields such as reproductive biology, neurological disorders, and skin diseases.
Yes, AREG has immunomodulatory properties and can influence immune cell functions, such as regulating T cell differentiation and function, and influencing the balance between immune activation and tolerance.
Yes, targeting AREG and its signaling pathways has shown promise in developing potential therapeutic interventions against cancer and other diseases.
AREG has the potential to be used in targeted therapy, especially in cancers where AREG signaling is implicated in promoting tumor growth and survival. Targeting AREG or its signaling pathways could potentially be used in combination with other therapies to improve treatment outcomes.
Yes, there are experimental inhibitors and anti-AREG antibodies being studied for their potential as therapeutic agents in various diseases, including cancer.
Yes, AREG has been shown to play a role in wound healing. It stimulates the migration and proliferation of cells involved in the wound healing process, such as fibroblasts and endothelial cells, promoting tissue repair.
AREG expression levels have been evaluated as potential diagnostic markers for certain types of cancer, including colorectal and breast cancer, to predict prognosis and guide treatment decisions.
In addition to its involvement in cellular proliferation, tissue development, and immune responses, AREG also influences processes such as cell migration, apoptosis, and stem cell maintenance.
There is limited evidence suggesting that genetic variations in the AREG gene may be associated with an increased risk of certain disorders, such as inflammatory diseases and certain types of cancers. However, more research is needed to fully understand the genetic implications of AREG.
AREG has shown promise in regenerative medicine due to its ability to stimulate tissue regeneration and repair. Further research is needed to fully understand its potential in this field.
Yes, AREG protein is involved in normal physiological processes such as tissue development, wound healing, and immune response regulation.
AREG expression levels have been evaluated as potential prognostic markers in several types of cancer. High AREG expression has been associated with poorer outcomes in some cases. However, further studies are needed to validate its clinical utility as a prognostic marker.
Yes, certain genetic mutations in the AREG gene have been identified and linked to specific disorders, including colorectal cancer and asthma.
AREG can activate various signaling pathways, including the EGFR (epidermal growth factor receptor) pathway, MAPK (mitogen-activated protein kinase) pathway, and PI3K (phosphoinositide 3-kinase)/Akt pathway.
There are ongoing efforts to develop inhibitors and antibodies targeting AREG for various therapeutic purposes, including cancer treatment. Some preclinical and early-stage clinical trials have been conducted, but more research is needed before these agents can be widely used in clinical practice.
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