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Official Full Name asialoglycoprotein receptor 2
Background This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms ASGR2; asialoglycoprotein receptor 2; CLEC4H2; ASGP R; ASGP-R 2; ASGPR 2; ASGPR2; ASGR2_HUMAN; C type lectin domain family 4 member H2; C-type lectin domain family 4 member H2; Hepatic lectin 2; Hepatic lectin H2; Hepatic lectin R2/3; HL-2; Hs.1259; L H2; LH2; MGC108546; MHL 2; RHL2; OTTHUMP00000128352; OTTHUMP00000128353; HBxAg-binding protein; HBXBP; ASGP-R2
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • MYC/DDK
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ASGR2-1492HCL Recombinant Human ASGR2 cell lysate Human Cell N/A
    Human ASGR2-197H Recombinant Human ASGR2 Protein, His-tagged E.coli His
    Human ASGR2-26516TH Recombinant Human ASGR2 Wheat Germ N/A
    Human ASGR2-2815H Recombinant Human ASGR2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ASGR2-6239H Recombinant Human ASGR2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ASGR2-7208H Recombinant Human Asialoglycoprotein Receptor 2, His-tagged E.coli His
    Human ASGR2-7375H Recombinant Human ASGR2, His tagged Human Cell His
    Human ASGR2-9932H Recombinant Human ASGR2, GST-tagged E.coli GST
    Mouse ASGR2-2450M Recombinant Mouse ASGR2 Protein (80-301 aa), His-Myc-tagged E.coli His/Myc
    Mouse Asgr2-3665M Recombinant Mouse Asgr2 Protein, His-tagged NS0 His
    Mouse Asgr2-657M Recombinant Mouse Asgr2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat ASGR2-821R Recombinant Rat ASGR2 Protein Mammalian Cell His

    asgr2 involved in several pathways and played different roles in them. We selected most pathways asgr2 participated on our site, such as Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with asgr2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone synthesis HSP90B1; ATP1B3; ITPR3; PRKACG; IYD; ATP1A2; LRP2; PRKCA; DUOX2; GPX8

    asgr2 has several biochemical functions, for example, asialoglycoprotein receptor activity, carbohydrate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by asgr2 itself. We selected most functions asgr2 had, and list some proteins which have the same functions with asgr2. You can find most of the proteins on our site.

    Function Related Protein
    asialoglycoprotein receptor activity ASGR2; ASGR1; LRPAP1
    carbohydrate binding CLEC2D; PRPS2; SIGLEC5; NOMO2; GRIFIN; GALNTL1; LGALSLA; GANC; LMAN2; NOMO1
    protein binding CDK5R1; MAPK15; MAP2K4; CUL3; TRAF1; PNKD; ACVR2A; CEP44; ARHGEF4; RAP2A

    asgr2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with asgr2 here. Most of them are supplied by our site. Hope this information will be useful for your research of asgr2.

    CERS2; GLUD1; HES1; q6zmw9_human

    Choi, J; Jeong, JM; et al. Ga-68-labeled neolactosylated human serum albumin (LSA) for PET imaging of hepatic asialoglycoprotein receptor. NUCLEAR MEDICINE AND BIOLOGY 42:53-58(2015).
    Kanno, Y; Watanabe, H; et al. Anti-phosphoenolpyruvate carboxykinase 2 antibody in patients with autoimmune hepatitis. HEPATOLOGY RESEARCH 44:1019-1025(2014).

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