ATP4B

  • Official Full Name

    ATPase, H+/K+ exchanging, beta polypeptide

  • Overview

    The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase;is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated;beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and;K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta;subunit of the gastric H+, K+-ATPase.
  • Synonyms

    ATP4B; ATPase, H+/K+ exchanging, beta polypeptide; potassium-transporting ATPase subunit beta; ATP6B; Gastric H(+)/K(+) ATPase subunit beta; ATPase H+/K+ exchanging beta polypeptide; ATPase H+/K+ transporting beta polypeptide; Gastric H K ATPase catalytic subunit; Gastric H+/K+ ATPase beta subunit; Gastric hydrogen potassium ATPase; Gastric hydrogen potassium ATPase beta; Hydrogen/potassium exchanging ATPase 4B; OTTHUMP00000178856; Potassium transporting ATPase beta chain; Potassium transporting ATPase subunit beta; Proton pump; Proton pump beta chain; gastric hydrogen-potassium ATPase, beta; potassium-transporting ATPase beta chain; ATPase, H+/K+ tra;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP4B-2943H Recombinant Human ATP4B protein, GST-tagged Wheat Germ GST
Human ATP4B-29416TH Recombinant Human ATP4B Wheat Germ N/A 110 amino acids
Human ATP4B-2435H Recombinant Human ATP4B protein, GST-tagged E.coli GST
Human ATP4B-8607HCL Recombinant Human ATP4B 293 Cell Lysate HEK293 N/A
Human ATP4B-2566H Recombinant Human ATP4B protein, N/A-tagged E.coli N/A 58-291aa
Human ATP4B-1337H Recombinant Human ATP4B Protein (58-291 aa), His-tagged Yeast His 58-291 aa
Human ATP4B-654HF Recombinant Full Length Human ATP4B Protein, GST-tagged In Vitro Cell Free System GST 291 amino acids
Mouse Atp4b-490M Recombinant Mouse Atp4b protein, His-tagged E.coli His
Mouse ATP4B-2128M Recombinant Mouse ATP4B Protein Mammalian Cell His
Mouse ATP4B-858M-B Recombinant Mouse ATP4B Protein Pre-coupled Magnetic Beads HEK293
Mouse ATP4B-858M Recombinant Mouse ATP4B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP4B-866R Recombinant Rat ATP4B Protein Mammalian Cell His
Rat ATP4B-522R Recombinant Rat ATP4B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP4B-522R-B Recombinant Rat ATP4B Protein Pre-coupled Magnetic Beads HEK293
Canis lupus familiaris (Dog) (Canis familiaris) RFL-2592CF Recombinant Full Length Dog Potassium-Transporting Atpase Subunit Beta(Atp4B) Protein, His-Tagged E.coli expression system His Full Length (1-290)
Mus musculus (Mouse) RFL-22870MF Recombinant Full Length Mouse Potassium-Transporting Atpase Subunit Beta(Atp4B) Protein, His-Tagged E.coli expression system His Full Length (1-294)
Oryctolagus cuniculus (Rabbit) RFL-27199OF Recombinant Full Length Rabbit Potassium-Transporting Atpase Subunit Beta(Atp4B) Protein, His-Tagged E.coli expression system His Full Length (1-291)
Rattus norvegicus (Rat) RFL-20900RF Recombinant Full Length Rat Potassium-Transporting Atpase Subunit Beta(Atp4B) Protein, His-Tagged E.coli expression system His Full Length (1-294)
Sus scrofa (Pig) RFL-2437SF Recombinant Full Length Pig Potassium-Transporting Atpase Subunit Beta(Atp4B) Protein, His-Tagged E.coli expression system His Full Length (1-290)
Chicken ATP4B-5988C Recombinant Chicken ATP4B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ATP4B involved in several pathways and played different roles in them. We selected most pathways ATP4B participated on our site, such as Oxidative phosphorylation, Collecting duct acid secretion, Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationNDUFS8B;NDUFAB1;ATP12A;PPA2;NDUFA9A;UQCRC2;SDHA;ATP5B;UQCRC1
Collecting duct acid secretionATP4A;TCIRG1;ATP6V1G2;ATP6V1E1;SLC12A7;CLCNKB;ATP6V1D;Car2;ATP6V1B2
Gastric acid secretionSLC9A4;KCNJ10;PRKACG;SST;GNAS;CALM3;Adcy4;PRKCA;PLCB2

ATP4B has several biochemical functions, for example, hydrogen:potassium-exchanging ATPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP4B itself. We selected most functions ATP4B had, and list some proteins which have the same functions with ATP4B. You can find most of the proteins on our site.

Function Related Protein
hydrogen:potassium-exchanging ATPase activityATP6V1E1B;ATP12A;ATP4B;ATP4A
protein bindingRNASEL;GLRX3;SLAMF1;KRTAP10-8;CYTH3;ARMC8;SPAT-1;NCF1;SERPINC1

ATP4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP4B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP4B.

CCNDBP1; BPGM; AGO3

  • Q&As
  • Reviews

Q&As (6)

Ask a question
Are there any studies on drugs that regulate gastric acid secretion by ATP4B? 03/19/2020

Yes, several studies have been devoted to the development of drugs that can modulate ATP4B activity for the regulation of gastric acid secretion and the treatment of related gastric diseases.

What is the regulatory mechanism of ATP4B in gastric acid secretion? 10/30/2019

ATP4B regulates gastric acid secretion through ATP binding and ion pump transport, and the specific mechanism involves the regulation of a variety of signaling pathways and hormones.

Is the abnormal expression of ATP4B valuable in the diagnosis and prognosis of gastric-related diseases? 05/08/2019

The abnormal expression of ATP4B can be used as an important indicator for the diagnosis and prognosis of some gastric-related diseases, but it needs to be comprehensively analyzed in combination with other clinical and molecular biological results.

What other proteins does ATP4B interact with? 04/28/2019

Interacts with other proteins in the Parietal cells of the gastric mucosa, such as those associated with the parietal cells of the gastric mucosa, to jointly regulate the production and secretion of gastric acid.

What is the mutation mechanism of ATP4B? 04/02/2019

Mutations in ATP4B may lead to abnormal changes in its intracellular localization and function, and then affect the normal secretion of gastric acid.

Is the polymorphism of ATP4B gene associated with abnormal gastric acid? 02/07/2019

Yes, polymorphic variations in the ATP4B gene may be associated with the susceptibility and pathogenesis of gastric acid abnormalities, such as hyperacidity or hypoacidity.

Customer Reviews (2)

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Reviews
12/22/2022

    Their wide range of products can meet our needs in different research areas.

    10/13/2021

      ATP4B were highly reproducible and showed good process control and product quality.

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