ATXN10
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Official Full Name
ataxin 10
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Overview
This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of a pentanucleotide repeat in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described. -
Synonyms
ATXN10; ataxin 10; SCA10, spinocerebellar ataxia 10; ataxin-10; E46L; FLJ37990; ATX10_HUMAN; Brain protein E46 homolog; HUMEEP; Like mouse brain protein E46; OTTHUMP00000197383; SCA10; Spinocerebellar ataxia 10; Spinocerebellar ataxia type 10 protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ATXN10 involved in several pathways and played different roles in them. We selected most pathways ATXN10 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ATXN10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ATXN10 has several biochemical functions, for example, enzyme binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATXN10 itself. We selected most functions ATXN10 had, and list some proteins which have the same functions with ATXN10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | HDAC3;ESR2;NOTCH3;HDAC6;IL6R;SLPI;CTNNB1;BACE1;TTN |
| identical protein binding | MICALL1;EGFR;PRPF3;ALDOA;P2RX2;UBE4A;SNX16;ANXA4;AGXT2L1 |
| protein binding | ATG3;GNAI1;ID1;UBE2D2;FCER1G;RABGAP1L;PREP;PNMA2;TOX4 |
ATXN10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATXN10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATXN10.
vpu; SAP18; PTP4A3; BSG; MAGEA6; ILK; TNFRSF14; PHB2; C20orf24; WRAP73; GSTK1; PHLDA3; MAGED1; STYXL1; HSPB1; LIMS1
- Q&As
- Reviews
Q&As (6)
Ask a questionThe research of ATXN10 protein mainly focuses on understanding its functional regulation mechanism, its relationship with the pathogenesis of SCA10, and the search for therapeutic methods for SCA10. At present, several important advances have been made regarding the function of ATXN10 protein and the pathogenesis of SCA10.
ATXN10 protein is involved in the regulation of a variety of neural cell functions, including transcription regulation, RNA processing, cell cycle regulation, etc. It plays an important role in the development and functional maintenance of the nervous system.
The function of ATXN10 protein is regulated by a variety of regulatory mechanisms, including the binding of transcriptional regulators and post-translational modifications. These regulatory mechanisms ensure the adaptability and stability of ATXN10 protein.
Yes, the ATXN10 protein interacts with multiple proteins to form complexes involved in the regulation of a variety of cellular functions. For example, ATXN10 interacts with TATA box binding protein (TBP) and participates in transcriptional regulation.
In addition to SCA10, ATXN10 protein has been implicated in the development and progression of other neurological diseases. For example, it may be associated with the pathogenesis of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. However, further studies are needed to confirm these associations.
The protein is associated with spinocerebellar ataxia type 10 (SCA10). SCA10 is an inherited neurodegenerative disorder characterized by dysfunction of the cerebellum and spinal cord leading to ataxia and other neurological symptoms.
Customer Reviews (3)
Write a reviewIt's the most biologically active protein I've ever seen, and the purity of its production is impressive.
This production process of Atxn10 uses renewable resources as raw materials, making the production process more environmentally friendly and sustainable.
The short half-life and high clearance of Atxn10 make them more safe and effective in clinical application.
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