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Recombinant Human ATXN10 protein, His & T7-tagged

Cat.No. : ATXN10-7957H
Product Overview : Recombinant Human ATXN10 aa. (Leu116~Ala302 (Accession # Q9UBB4)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.
Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 25.2kDa
Protein length : Leu116~Ala302 (Accession # Q9UBB4)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 4.7.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage Buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : ATXN10 ataxin 10 [ Homo sapiens (human) ]
Official Symbol : ATXN10
Synonyms : ATXN10; ataxin 10; E46L; SCA10; HUMEEP; ataxin-10; brain protein E46 homolog; spinocerebellar ataxia type 10 protein
Gene ID : 25814
mRNA Refseq : NM_001167621.1
Protein Refseq : NP_001161093.1
UniProt ID : Q9UBB4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What progress has been made in ATXN10 protein research? 12/10/2022

The research of ATXN10 protein mainly focuses on understanding its functional regulation mechanism, its relationship with the pathogenesis of SCA10, and the search for therapeutic methods for SCA10. At present, several important advances have been made regarding the function of ATXN10 protein and the pathogenesis of SCA10.

Which role of ATXN10 protein in humans? 01/11/2022

ATXN10 protein is involved in the regulation of a variety of neural cell functions, including transcription regulation, RNA processing, cell cycle regulation, etc. It plays an important role in the development and functional maintenance of the nervous system.

What is the regulatory mechanism of ATXN10 protein function? 12/17/2021

The function of ATXN10 protein is regulated by a variety of regulatory mechanisms, including the binding of transcriptional regulators and post-translational modifications. These regulatory mechanisms ensure the adaptability and stability of ATXN10 protein.

Does ATXN10 protein interact with other proteins? 05/18/2021

Yes, the ATXN10 protein interacts with multiple proteins to form complexes involved in the regulation of a variety of cellular functions. For example, ATXN10 interacts with TATA box binding protein (TBP) and participates in transcriptional regulation.

Is ATXN10 protein associated with other neurological diseases? 04/07/2020

In addition to SCA10, ATXN10 protein has been implicated in the development and progression of other neurological diseases. For example, it may be associated with the pathogenesis of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. However, further studies are needed to confirm these associations.

Which diseases are associated with ATXN10 protein? 01/09/2020

The protein is associated with spinocerebellar ataxia type 10 (SCA10). SCA10 is an inherited neurodegenerative disorder characterized by dysfunction of the cerebellum and spinal cord leading to ataxia and other neurological symptoms.

Customer Reviews (3)

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Reviews
07/15/2022

    It's the most biologically active protein I've ever seen, and the purity of its production is impressive.

    06/03/2022

      This production process of Atxn10 uses renewable resources as raw materials, making the production process more environmentally friendly and sustainable.

      11/20/2019

        The short half-life and high clearance of Atxn10 make them more safe and effective in clinical application.

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