BACE1

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BACE1

Official Full Name beta-site APP-cleaving enzyme 1
Background Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimers disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Synonyms BACE1; beta-site APP-cleaving enzyme 1; ASP2; BACE; HSPC104; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • Flag
    • GST
    • His
    • human
    • IgG1
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BACE1-0398H Recombinant Human BACE1 protein, His-tagged E.coli His
    Human BACE1-002H Recombinant Human BACE1 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human BACE1-003H Recombinant Human BACE1 protein HEK293
    Human BACE1-102H Recombinant Human BACE1, GST-tagged Wheat Germ GST
    Human BACE1-1661H Recombinant Human Beta-Site APP-Cleaving Enzyme 1 E.coli N/A
    Human BACE1-219H Recombinant Human BACE1, C13&N15-labeled HEK293 N/A
    Human BACE1-2200H Recombinant Human BACE1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human BACE1-253H Recombinant Human BACE1, Fc tagged Human Cell Fc
    Human BACE1-255H Recombinant Human BACE1, None tagged Human Cell N/A
    Human BACE1-26297TH Recombinant Human BACE1 E.coli N/A
    Human BACE1-2682H Recombinant Human BACE1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human BACE1-27426TH Recombinant Human BACE1, FLAG-tagged Flag
    Human BACE1-3006HCL Recombinant Human BACE1 cell lysate Human Cell N/A
    Human BACE1-31H Recombinant Human Beta-Site APP-Cleaving Enzyme 1 E.coli N/A
    Human BACE1-713H Recombinant Human BACE1 protein, His & GST-tagged E.coli His/GST
    Human BACE1-891H Recombinant Human BACE1 protein, His-tagged HEK293 His
    Mouse Bace1-1815M Recombinant Mouse Bace1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Bace1-252M Recombinant Mouse Bace1, His tagged Human Cell His
    Mouse BACE1-3077MCL Recombinant Mouse BACE1 cell lysate Human Cell N/A
    Mouse Bace1-714M Recombinant Mouse Bace1 protein, His & GST-tagged E.coli His/GST
    Rat Bace1-715R Recombinant Rat Bace1 protein, His-tagged E.coli His
    Rat BACE1-929R Recombinant Rat BACE1 Protein Mammalian Cell His
    Rhesus Macaque BACE1-503R Recombinant Rhesus monkey BACE1 Protein, His-tagged Mammalian Cell His
    Zebrafish BACE1-11726Z Recombinant Zebrafish BACE1 Mammalian Cell His

    BACE1 involved in several pathways and played different roles in them. We selected most pathways BACE1 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with BACE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease APBB1; APOE; BAD; NDUFC2; ITPR3; NDUFB11; CALM1; APH1B; GRIN2A; COX6A1

    BACE1 has several biochemical functions, for example, aspartic-type endopeptidase activity, beta-amyloid binding, beta-aspartyl-peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BACE1 itself. We selected most functions BACE1 had, and list some proteins which have the same functions with BACE1. You can find most of the proteins on our site.

    Function Related Protein
    aspartic-type endopeptidase activity Ren1; PSEN1; PGA; CTSE; PIP; SPPL2; CTSD; PGC; NOTS; PGA4
    beta-amyloid binding SORL1; BCHE; TM2D1; APBB1; ITM2C; Apba1; APOEA; APBA2; HBA-A2; BACE1
    beta-aspartyl-peptidase activity BACE1
    enzyme binding TOP2A; BRCA1; CTNNB1; Il6ra; ERN1; BCR; TRAF2; MLL5; HIST1H2AM; HSPA6
    peptidase activity MMP30; KLK5; UFSP2; USP2A; HE2; PSMB11; TMPRSS13A; AZU1; DESI1; CAPN3A
    protein binding TMEM79; MAP2K7; LIMA1; CRTC2; SOD1; DUSP14; ZNF193; WDYHV1; SPRY4; GLS

    BACE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BACE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BACE1.

    Clec4g; FLOT2; APP; Flot1; FLOT1; MMP2; CSNK1D; App

    Sadleir, KR; Eimer, WA; et al. A beta reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level. Molecular Neurodegeneration 10:-(2015).
    Yu, YJ; Atwal, JK; et al. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. SCIENCE TRANSLATIONAL MEDICINE 6:-(2014).

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