bace1
Share
  • Official Full Name
  • beta-site APP-cleaving enzyme 1
  • Background
  • Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimers disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
  • Synonyms
  • BACE1; beta-site APP-cleaving enzyme 1; ASP2; BACE; HSPC104; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme;
Cat.#:BACE1-2200HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BACE1 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:BACE1-102HTag:GST
Source (Host):Species:Human
Product nameRecombinant Human BACE1, GST-tagged
+Inquiry
Cat.#:BACE1-31HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Beta-Site APP-Cleaving Enzyme 1
+Inquiry
Cat.#:BACE1-1661HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Beta-Site APP-Cleaving Enzyme 1
+Inquiry
Cat.#:BACE1-002HTag:Fc
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human BACE1 Protein, Fc-tagged
+Inquiry
Cat.#:BACE1-003HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human BACE1 Protein
+Inquiry
Cat.#:BACE1-219HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human BACE1, C13&N15-labeled
+Inquiry
Cat.#:BACE1-253HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human BACE1, Fc tagged
+Inquiry
Cat.#:BACE1-255HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human BACE1, None tagged
+Inquiry
Cat.#:BACE1-26297THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BACE1
+Inquiry
Cat.#:BACE1-27426THTag:Flag
Source (Host):Species:Human
Product nameRecombinant Human BACE1, FLAG-tagged
+Inquiry
Cat.#:BACE1-713HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BACE1 protein, His & GST-tagged
+Inquiry
Cat.#:BACE1-891HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human BACE1, His tagged
+Inquiry
Cat.#:Bace1-252MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Bace1, His tagged
+Inquiry
Cat.#:Bace1-714MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bace1 protein, His & GST-tagged
+Inquiry
Cat.#:Bace1-715RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Bace1 protein, His-tagged
+Inquiry
Cat.#:BACE1-929RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BACE1 Protein
+Inquiry
Cat.#:BACE1-503RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BACE1 Protein, His-tagged
+Inquiry
Cat.#:BACE1-11726ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BACE1
+Inquiry
Cat.#:BACE1-3006HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human BACE1 cell lysate
+Inquiry
Cat.#:BACE1-3077MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse BACE1 cell lysate
+Inquiry
Cat.#:CSC-P0539Tag:
Source (Host):Species:Human
Product nameAnti-Human BACE1 MAb Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-P0540Tag:
Source (Host):Species:Human
Product nameAnti-Human BACE1 F(ab) Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-P0541Tag:
Source (Host):Species:Human
Product nameAnti-Human BACE1 scFv Stable Cell Line-CHO
+Inquiry

Involved Pathway

BACE1 involved in several pathways and played different roles in them. We selected most pathways BACE1 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with BACE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alzheimers disease
CALML5; GSK3B; UQCR11; ATP5D; APP; NDUFA8; Casp3; NDUFA11; UQCRH; ATP5J

Protein Function

BACE1 has several biochemical functions, for example, aspartic-type endopeptidase activity, beta-amyloid binding, beta-aspartyl-peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BACE1 itself. We selected most functions BACE1 had, and list some proteins which have the same functions with BACE1. You can find most of the proteins on our site.
Function
Related Protein
Function aspartic-type endopeptidase activity
Related Protein NAPSA; PSEN1; PSEN2; PIP; BACE2; NRIP2; NRIP3; PGA5; CNTNAP5A; Ren1
Function beta-amyloid binding
Related Protein HSD17B10; Apba1; ACHE; APBB2; IDE; BACE2; COL25A1; LDLRAD3; ITM2C; TGFB2
Function beta-aspartyl-peptidase activity
Related Protein BACE1
Function enzyme binding
Related Protein BLZF1; HMGA1-RS1; CDK19; HDHD2; GNB2L1; RYR2; PTPLAD1; KALRN; NOTCH3; LAMP2
Function peptidase activity
Related Protein CTSSA; CAPN5A; CLCA3; PARLA; ZMPSTE24; CAPN3A; SPCS3; HM13; TPP1; IHHA
Function protein binding
Related Protein ARHGDIG; TRIM23; LHFPL5; SET; FAM127A; MBL2; PHF17; BANF1; SNX31; PRMT5

Interacting Protein

BACE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BACE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BACE1.
Clec4g; FLOT2; APP; Flot1; FLOT1; MMP2; CSNK1D; App

BACE1 Related Articles

Sadleir, KR; Eimer, WA; et al. A beta reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level. Molecular Neurodegeneration 10:-(2015).
Yu, YJ; Atwal, JK; et al. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. SCIENCE TRANSLATIONAL MEDICINE 6:-(2014).