BAIAP2
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Official Full Name
BAI1-associated protein 2
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Overview
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein.;This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an;insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also;associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers;and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect;neuronal growth-cone guidance. This protein has also been identified as interacting with the;dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease.;Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
BAIAP2; BAI1-associated protein 2; brain-specific angiogenesis inhibitor 1-associated protein 2; BAP2; IRS-58; IRSp53/58; fas ligand-associated factor 3; insulin receptor substrate p53/p58; insulin receptor substrate protein of 53 kDa; FLAF3; IRSP53;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- DDK
- GST
- His
- His (Fc)
- Avi
- Myc
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
BAIAP2 involved in several pathways and played different roles in them. We selected most pathways BAIAP2 participated on our site, such as Adherens junction, CDC42 signaling events, ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAIAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adherens junction | TCF7L1A;ACTN3B;Fert2;LMO7A;CTNNA1;RAC3A;VCLA;ACTB2;SNAI1 |
| CDC42 signaling events | ACTR2;ARPC4;CTNNA1;PAK4;ARPC5;ARPC2;ARPC1B;CFL1;TNK2 |
| ErbB1 downstream signaling | ACTR2;CHN2;EPS8;ARF4;NCKAP1;WASF2;BAIAP2;EGR1;ABI1 |
| Fcgamma receptor (FCGR) dependent phagocytosis | WASF2;MYO9B;ACTR3;ACTR2;PPAPDC1A;NCKAP1;ABI1A;WASF3;NCKIPSD |
| Immune System | IFI35;WIPF2;CLEC2B;TCIRG1;CD200R2;DEFB1;KIF18A;KIF4;ABI1A |
| Innate Immune System | FAM49BA;BAIAP2;KIR3DS1;BTR22;IRAK3;BTR29;DEFA3;DEFA5;ABI1 |
| RAC1 signaling pathway | NOXO1;NOXA1;IQGAP3;ABI2;NCKAP1;RACGAP1;BAIAP2;ABI1 |
| RHO GTPase Effectors | RCC2;ABI1;RHPN2;RANGAP1B;SPDL1;CDCA8;KIF14;NCKIPSD;SKA2 |
BAIAP2 has several biochemical functions, for example, PDZ domain binding, cytoskeletal adaptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAIAP2 itself. We selected most functions BAIAP2 had, and list some proteins which have the same functions with BAIAP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | ADAM17;DLC;LIN7C;CXXC4;SLC9A3;SLC9A3R2;SRR;KCNJ4;PARK2 |
| cytoskeletal adaptor activity | BAIAP2L2B;SDCBP;GAS2L2;BAIAP2;BAIAP2L1;GAS2L1;NCK1;SORBS2;BAIAP2L1A |
| identical protein binding | KRTAP10-5;RCAN1;PRKAB2;DPP9;HSPB8;IGF1R;TRP63;CLDN15;PRDX3 |
| proline-rich region binding | TCERG1;ITSN1;ABL1;WBP4;YAP1;ABI2;CYLD;CCND1;BAIAP2L1 |
| protein C-terminus binding | SIAH1;CACNA1B;DLG1;TAX1BP3;MLLT4;RABAC1;PICK1;TBL1X;PXK |
| protein binding | GSK3B;PURA;KLB;EIF2B4;FOXJ2;CHRDL2;MALSU1;SERP1;SMAD1 |
BAIAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAIAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAIAP2.
EPS8; RAC1; Eps8
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