| Description : |
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms |
| Source : |
Wheat Germ |
| Species : |
Human |
| Tag : |
GST |
| Form : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Molecular Mass : |
82.06 kDa |
| AA Sequence : |
MSLSRSEEMHRLTENVYKTIMEQFN PSLRNFIAMGKNYEKALAGVTYAAK GYFDALVKMGELASESQGSKELGDV LFQMAEVHRQIQNQLEEMLKSFHNE LLTQLEQKVELDSRYLSAALKKYQT EQRSKGDALDKCQAELKKLRKKSQG SKNPQKYSDKELQYIDAISNKQGEL ENYVSDGYKTALTEERRRFCFLVEK QCAVAKNSAAYHSKGKELLAQKLPL WQQACADPSKIPERAVQLMQQVASN GATLPSALSASKSNLVISDPIPGAK PLPVPPELAPFVGRMSAQESTPIMN GVTGPDGEDYSPWADRKAAQPKSLS PPQSQSKLSDSYSNTLPVRKSVTPK NSYATTENKTLPRSSSMAAGLERNG RMRVKAIFSHAAGDNSTLLSFKEGD LITLLVPEARDGWHYGESEKTKMRG WFPFSYTRVLDSDGSDRLHMSLQQG KSSSTGNLLDKDDLAIPPPDYGAAS RAFPAQTASGFKQRPYSVAVPAFSQ GLDDYGARSMSR |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
