Description : |
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
57.4 kDa |
AA Sequence : |
MSLSRSEEMHRLTENVYKTIMEQFN PSLRNFIAMGKNYEKALAGVTYAAK GYFDALVKMGELASESQGSKELGDV LFQMAEVHRQIQNQLEEMLKSFHNE LLTQLEQKVELDSRYLSAALKKYQT EQRSKGDALDKCQAELKKLRKKSQG SKNPQKYSDKELQYIDAISNKQGEL ENYVSDGYKTALTEERRRFCFLVEK QCAVAKNSAAYHSKGKELLAQKLPL WQQACADPSKIPERAVQLMQQVASN GATLPSALSASKSNLVISDPIPGAK PLPVPPELAPFVGRMSAQESTPIMN GVTGPDGEDYSPWADRKAAQPKSLS PPQSQSKLSDSYSNTLPVRKSVTPK NSYATTAENKTLPRSSSMAAGLERN GRMRVKAIFSHAAGDNSTLLSFKEG DLITLLVPEARDGWHYGESEKTKMR GWFPFSYTRVLDSDGSDRLHMSLQQ GKSSSTGNLLDKDDLAIPPPDYGAA SRAFPAQTASGFKQRPYSVAVPAFS QGLDDYGARSMSSGSGTLVSTVTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |