Recombinant Human BMPR2 Protein, GST-tagged
Cat.No. : | BMPR2-287H |
Product Overview : | Human BMPR2 (NP_001195.2, 174 a.a. - 1038 a.a.) partial recombinant protein with GST tag expressed in baculovirus infected Sf21 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. |
Source : | Sf21 cells |
Species : | Human |
Tag : | GST |
Form : | In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol) |
Molecular Mass : | 123 kDa |
Purity : | 69 % by SDS-PAGE/CBB staining |
Quality Control Test : | Loading 1 ug protein in SDS-PAGE |
Notes : | Result of activity analysis |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol) |
Gene Name : | BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) [ Homo sapiens ] |
Official Symbol : | BMPR2 |
Synonyms : | BMPR2; bone morphogenetic protein receptor, type II (serine/threonine kinase); PPH1, primary pulmonary hypertension 1; bone morphogenetic protein receptor type-2; BMPR II; BMPR3; BRK 3; T ALK; BMPR-2; BMP type-2 receptor; BMP type II receptor; type II activin receptor-like kinase; bone morphogenetic protein receptor type II; type II receptor for bone morphogenetic protein-4; BMR2; PPH1; BRK-3; T-ALK; BMPR-II; FLJ41585; FLJ76945; |
Gene ID : | 659 |
mRNA Refseq : | NM_001204 |
Protein Refseq : | NP_001195 |
MIM : | 600799 |
UniProt ID : | Q13873 |
Products Types
◆ Recombinant Protein | ||
Bmpr2-715M | Recombinant Mouse Bmpr2 Protein, MYC/DDK-tagged | +Inquiry |
BMPR2-451H | Recombinant Human BMPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
BMPR2-377R | Recombinant Rhesus Macaque BMPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
BMPR2-2707H | Recombinant Human BMPR2 Protein, MYC/DDK-tagged | +Inquiry |
BMPR2-1060M | Recombinant Mouse BMPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
BMPR2-2717HCL | Recombinant Human BMPR2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionBMPR2 plays a significant role in PAH, influencing vascular cell proliferation and vascular remodeling.
Mutations in BMPR2 contribute to hereditary hemorrhagic telangiectasia, impacting vascular development.
Changes in BMPR2 signaling impact embryonic development, potentially resulting in congenital anomalies.
Dysregulation of BMPR2 affects renal function, potentially leading to kidney disease and dysfunction.
BMPR2 is key in bone morphogenetic protein signaling, crucial for bone growth and remodeling.
BMPR2 is involved in cardiovascular development, particularly affecting heart valve formation and function.
BMPR2 regulates cell proliferation and apoptosis, playing a role in tissue homeostasis.
Customer Reviews (3)
Write a reviewHigh-quality protein crystallography services, exceptional outcomes.
Critical expertise in protein engineering, unmatched service quality.
Swift and reliable protein sequencing, invaluable for our research.
Ask a Question for All BMPR2 Products
Required fields are marked with *
My Review for All BMPR2 Products
Required fields are marked with *
Inquiry Basket