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Recombinant Human BMPR2 protein, His & T7-tagged

Cat.No. : BMPR2-577H
Product Overview : Recombinant Human BMPR2 (Q13873) aa. (Ser27~Thr150) fused with N-terminal His & T7 tag was produced in E. coli cells.
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Description : This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 17.7kDa
Protein length : Ser27~Thr150 (Accession # Q13873)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Characteristic : The isoelectric point is 6.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4
Gene Name : BMPR2 bone morphogenetic protein receptor type 2 [ Homo sapiens (human) ]
Official Symbol : BMPR2
Synonyms : BMPR2; bone morphogenetic protein receptor type 2; BMR2; PPH1; BMPR3; BRK-3; POVD1; T-ALK; BMPR-II; bone morphogenetic protein receptor type-2; BMP type II receptor; BMP type-2 receptor; bone morphogenetic protein receptor type II; bone morphogenetic protein receptor, type II (serine/threonine kinase); type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4
Gene ID : 659
mRNA Refseq : NM_001204.6
Protein Refseq : NP_001195.2
UniProt ID : Q13873

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does BMPR2 play in the development and progression of pulmonary arterial hypertension (PAH)? 02/01/2022

BMPR2 plays a significant role in PAH, influencing vascular cell proliferation and vascular remodeling.

What is the impact of BMPR2 mutations on hereditary hemorrhagic telangiectasia? 11/19/2020

Mutations in BMPR2 contribute to hereditary hemorrhagic telangiectasia, impacting vascular development.

How do alterations in BMPR2 expression or signaling affect embryonic development and congenital anomalies? 05/14/2020

Changes in BMPR2 signaling impact embryonic development, potentially resulting in congenital anomalies.

What are the effects of BMPR2 dysregulation on renal function and kidney disease? 05/05/2020

Dysregulation of BMPR2 affects renal function, potentially leading to kidney disease and dysfunction.

How does BMPR2 mediate the signaling pathways of bone morphogenetic proteins (BMPs) in bone formation and remodeling? 06/01/2019

BMPR2 is key in bone morphogenetic protein signaling, crucial for bone growth and remodeling.

How does BMPR2 influence cardiovascular development and disease, particularly in heart valve formation? 01/20/2019

BMPR2 is involved in cardiovascular development, particularly affecting heart valve formation and function.

How does BMPR2 contribute to the regulation of cell proliferation and apoptosis in various tissues? 04/18/2018

BMPR2 regulates cell proliferation and apoptosis, playing a role in tissue homeostasis.

Customer Reviews (3)

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Reviews
11/20/2022

    High-quality protein crystallography services, exceptional outcomes.

    04/28/2022

      Critical expertise in protein engineering, unmatched service quality.

      07/29/2019

        Swift and reliable protein sequencing, invaluable for our research.

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