Recombinant Human BMPR2 protein, His & T7-tagged
Cat.No. : | BMPR2-577H |
Product Overview : | Recombinant Human BMPR2 (Q13873) aa. (Ser27~Thr150) fused with N-terminal His & T7 tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. |
Source : | E. coli |
Species : | Human |
Tag : | His & T7 |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 17.7kDa |
Protein length : | Ser27~Thr150 (Accession # Q13873) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | > 95% |
Characteristic : | The isoelectric point is 6. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4 |
Gene Name : | BMPR2 bone morphogenetic protein receptor type 2 [ Homo sapiens (human) ] |
Official Symbol : | BMPR2 |
Synonyms : | BMPR2; bone morphogenetic protein receptor type 2; BMR2; PPH1; BMPR3; BRK-3; POVD1; T-ALK; BMPR-II; bone morphogenetic protein receptor type-2; BMP type II receptor; BMP type-2 receptor; bone morphogenetic protein receptor type II; bone morphogenetic protein receptor, type II (serine/threonine kinase); type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4 |
Gene ID : | 659 |
mRNA Refseq : | NM_001204.6 |
Protein Refseq : | NP_001195.2 |
UniProt ID : | Q13873 |
Products Types
◆ Recombinant Protein | ||
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BMPR2-377R | Recombinant Rhesus Macaque BMPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
BMPR2-451H | Recombinant Human BMPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Bmpr2-715M | Recombinant Mouse Bmpr2 Protein, MYC/DDK-tagged | +Inquiry |
BMPR2-2707H | Recombinant Human BMPR2 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
BMPR2-2717HCL | Recombinant Human BMPR2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionBMPR2 plays a significant role in PAH, influencing vascular cell proliferation and vascular remodeling.
Mutations in BMPR2 contribute to hereditary hemorrhagic telangiectasia, impacting vascular development.
Changes in BMPR2 signaling impact embryonic development, potentially resulting in congenital anomalies.
Dysregulation of BMPR2 affects renal function, potentially leading to kidney disease and dysfunction.
BMPR2 is key in bone morphogenetic protein signaling, crucial for bone growth and remodeling.
BMPR2 is involved in cardiovascular development, particularly affecting heart valve formation and function.
BMPR2 regulates cell proliferation and apoptosis, playing a role in tissue homeostasis.
Customer Reviews (3)
Write a reviewHigh-quality protein crystallography services, exceptional outcomes.
Critical expertise in protein engineering, unmatched service quality.
Swift and reliable protein sequencing, invaluable for our research.
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