BTRC

  • Official Full Name

    beta-transducin repeat containing E3 ubiquitin protein ligase
  • Overview

    beta-transducin repeat-containing protein (beta-TrCP or FBW1A) is an F-box family protein characterized by the presence of the protein-protein mediating F-box domain first described in cyclin F. F box proteins act as substrate adapters that target protein
  • Synonyms

    BTRC;beta-transducin repeat containing E3 ubiquitin protein ligase;beta transducin repeat containing;F-box/WD repeat-containing protein 1A;beta TrCP1;betaTrCP;bTrCP;bTrCP1;FBXW1A;Fwd1;beta-TrCP1;E3RSIkappaB;F-box and WD-repeat protein 1B;pIka

Recombinant Proteins

  • Mouse
  • Cynomolgus
  • Human
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • E.coli
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
BTRC-2545M Recombinant Mouse BTRC Protein Mammalian Cells Mouse His
BTRC-351C Recombinant Cynomolgus BTRC Protein, His-tagged Mammalian Cells Cynomolgus His
BTRC-399H Recombinant Human BTRC Protein, GST-tagged Wheat Germ Human GST
BTRC-8384HCL Recombinant Human BTRC 293 Cell Lysate HEK293 Human Non
BTRC-1118M Recombinant Mouse BTRC Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
BTRC-1118M-B Recombinant Mouse BTRC Protein Pre-coupled Magnetic Beads HEK293 Mouse
BTRC-11H Recombinant Human BTRC protein, His-tagged E.coli Human His 1-365 aa
BTRC-12H Recombinant Human BTRC protein, GST-tagged E.coli Human GST 308-605 aa
BTRC-1687HF Recombinant Full Length Human BTRC Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 605 amino acids
BTRC-99C Recombinant Cynomolgus Monkey BTRC Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
BTRC-99C-B Recombinant Cynomolgus Monkey BTRC Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus

    Involved Pathway

    BTRC involved in several pathways and played different roles in them. We selected most pathways BTRC participated on our site, such as Oocyte meiosis,Ubiquitin mediated proteolysis,Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BTRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hedgehog signaling pathway GLI3,SHHA,RAB23,PTCH1,SKI,WNT2BB,WNT2BA,WNT9A,CSNK1G1,WNT7B
    Shigellosis VCL,ACTG1,UBE2D2,MAPK11,SRC,MAD2L2,IKBKB,MAPK3,MAPK12,MAPK10
    Hippo signaling pathway TGFBR2,NKD1,FZD2,TEAD3,PPP1CA,SMAD4,WTIP,AFP,SNAI2,CDH1
    Ubiquitin mediated proteolysis ERCC8,UBE2D1B,UBA1,FZR1A,UBE2M,UBE2I,UBE2E3,UBE2L3,MAP3K1,UBA6
    Oocyte meiosis MAPK12,CAMK2G1,PPP2R5EB,PPP3R2,CDC16,CDC20,MAD2L2,YWHAE1,MAPK12B,CTH1
    Wnt signaling pathway PRKACG,INVS,WNT2B,CSNK2A2A,WNT3,NFATC4,MYCB,WNT2BA,FZD9,PRKCG
    Circadian rhythm PER2,PER1,NPAS2,NR1D1,SKP1,PRKAB2,PRKAB1,PER3,FBXL3,BHLHE40

    Protein Function

    BTRC has several biochemical functions, for example, beta-catenin binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BTRC itself. We selected most functions BTRC had, and list some proteins which have the same functions with BTRC. You can find most of the proteins on our site.

    Function Related Protein
    beta-catenin binding LEF1,APC,NF2,KDM6B,AXIN1,PXN,BCL9,TCF7L1B,ASH2L,BCL9L
    protein binding MAP3K2,UBXN6,GSN,RARB,EIF3D,PDZD7,RAC3,SVIL,FAM122A,MSRB3
    ubiquitin protein ligase activity C12orf51,RNF126,RBX1,ANAPC11,ARIH2,ANKIB1,RNF220,RAG2,CBLL1,RNF41
    protein phosphorylated amino acid binding CRK,ARRB1
    contributes_to ubiquitin-protein transferase activity TCEB3,KLHDC7B,KCTD10,KLHL13,UBE2S,KLHL9,RNF2,KLHL14,KLHL29,BARD1
    protein dimerization activity OLIG4,ANO4,TFE3B,ZBED1,CLOCKB,MTOR,SMG1,EBF1,OLIG3,NEUROG1
    ligase activity ATG10,UBE2L3A,BARD1,TRAIP,RNF123,MGRN1,TRIP12,MARCH9,TRIM68,RAG1

    Interacting Protein

    BTRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BTRC here. Most of them are supplied by our site. Hope this information will be useful for your research of BTRC.

    SKP1;CUL1;CTNNB1

    Resources

    References

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