Recombinant Human CA8 protein, GST-tagged

• Cat.No.: CA8-2618H
• Product Overview: Recombinant Human CA8 protein(P35219)(1-290aa), fused to N-terminal GST tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 60 kDa
• Protein length: 1-290aa
• AA Sequence: MADLSFIEDTVAFPEKEEDEEEEEE GVEWGYEEGVEWGLVFPDANGEYQS PINLNSREARYDPSLLDVRLSPNYV VCRDCEVTNDGHTIQVILKSKSVLS GGPLPQGHEFELYEVRFHWGRENQR GSEHTVNFKAFPMELHLIHWNSTLF GSIDEAVGKPHGIAIIALFVQIGKE HVGLKAVTEILQDIQYKGKSKTIPC FNPNTLLPDPLLRDYWVYEGSLTIP PCSEGVTWILFRYPLTISQLQIEEF RRLRTHVKGAELVEGCDGILGDNFR PTQPLSDRVIRAAFQ
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: CA8 carbonic anhydrase VIII [ Homo sapiens ]
• Official Symbol: CA8
• Synonyms: CA8; carbonic anhydrase VIII; CALS; carbonic anhydrase-related protein; CARP; CA-related protein; carbonate dehydratase; carbonic anhydrase-like sequence; CAMRQ3; CA-VIII; MGC99509; MGC120502
• Gene ID: 767
• mRNA Refseq: NM_004056
• Protein Refseq: NP_004047
• MIM: 114815
• UniProt ID: P35219

Reviews

10/17/2021

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09/18/2021

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08/02/2021

Quick and precise protein quantification services.

Q&As

Are there specific proteins or molecules known to interact with CA8?

CA8 interacts with IP3Rs, affecting calcium signaling in neurons.

How does CA8's role differ from the enzymatically active carbonic anhydrase isoforms?

Unlike enzymatically active isoforms, CA8 doesn't catalyze the hydration of CO2 but instead plays roles in neuronal signaling and function.

Are there genetic mutations in the CA8 gene that are linked to specific diseases?

Mutations in CA8 have been linked to cerebellar ataxia, a movement disorder.

How does CA8 contribute to cellular processes, given its non-enzymatic nature?

CA8 impacts calcium signaling in neurons, affecting neural communication and potentially influencing motor control.

What post-translational modifications are typical for CA8?

Specific modifications, like phosphorylation, can be explored using mass spectrometry or targeted biochemical assays.

What is the primary function of CA8, considering it's a non-enzymatic member of the carbonic anhydrase family?

CA8 acts as a stabilizer for inositol 1,4,5-trisphosphate receptors (IP3Rs) in neurons.

In which human tissues or cell types is CA8 predominantly expressed?

CA8 is mainly expressed in the cerebellum, particularly in Purkinje cells.