cbl
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  • Official Full Name
  • Cas-Br-M (murine) ecotropic retroviral transforming sequence
  • Background
  • The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
  • Synonyms
  • 4732447J05Rik; C CBL; Cas Br M (murine) ecotropic retroviral transforming sequence; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B lineage lymphoma proto oncogene; Casitas B-lineage lymphoma proto-oncogene; CBL 2; cbl; CBL_HUMAN; CBL2; E3 ubiquitin protein ligase CBL; E3 ubiquitin-protein ligase CBL; Oncogene CBL2; Proto oncogene c CBL; Proto-oncogene c-CBL; RGD1561386; RING finger protein 55; RNF55; Signal transduction protein CBL; OTTHUMP00000232087
Cat.#:CBL-1801ATag:His|SUMO
Source (Host):E. coliSpecies:Arabidopsis Thaliana
Product nameRecombinant Arabidopsis Thaliana CBL Protein (70-464 aa), His-SUMO-tagged
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Cat.#:CBL-0457HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CBL Protein, GST-Tagged
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Cat.#:CBL-2727HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CBL Protein, MYC/DDK-tagged
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Cat.#:CBL-1390HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CBL protein, His & GST-tagged
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Cat.#:CBL-26492THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CBL
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Cat.#:CBL-26493THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CBL
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Cat.#:CBL-2779MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CBL Protein
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Cat.#:CBL-638RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CBL Protein, His-tagged
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Cat.#:CBL-5782CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CBL
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Cat.#:CBL-1720ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CBL
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Cat.#:CBL-287HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CBL cell lysate
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Involved Pathway

CBL involved in several pathways and played different roles in them. We selected most pathways CBL participated on our site, such as ErbB signaling pathway, Ubiquitin mediated proteolysis, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
CDKN1BA; EREG; MAPK8; MAP2K4; PIK3CD; PAK1; PRKCA; SHC1; PAK3; PIK3R2
Ubiquitin mediated proteolysis
ERCC8; UBE2D1B; SAE1; UBE3B; MID1; UBE2D2A; PARK2; TRIM32; UBA2; UBA1
Endocytosis
PIP5K1AB; RHOAA; PIP5K1A; TGFBR1A; NTRK1; BF2; SH3GLB2; MHC1UEA; RAB11FIP1; CAPZA3
T cell receptor signaling pathway
PAK1; PIK3CG; NRAS; TNF; ZAP70; PIK3R3; FOS; FYN; PAK3; GSK3B
Insulin signaling pathway
PRKACB; HRASB; MTOR; LIPE; GYS1; EXOC7; PRKCI; CALML3; PRKAA1; EIF4EA
Bacterial invasion of epithelial cells
ITGA5; CTNNA2; WASL; CLTC; SHC4; HCLS1; VCL; PXN; CBL; CAV1
Pathways in cancer
PLCB2; CBLC; APPL1; FGF9; PTCH2; WNT2; CCNE1; WNT4; TRP53; ITGA3
Proteoglycans in cancer
MAP2K2; FLNC; LUM; CTTN; HGF; MMP9; NUDT16L1; ACTB; TLR2; MET
Chronic myeloid leukemia
RELA; PIK3R1; MDM2; CTBP1; SOS1; TGFB2; SHC2; TGFB1; ABL1; IKBKB

Protein Function

CBL has several biochemical functions, for example, SH3 domain binding, calcium ion binding, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBL itself. We selected most functions CBL had, and list some proteins which have the same functions with CBL. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein SH3BGR; INPPL1B; LANCL1; SGIP1; INPPL1; SH3BGRL2; ABI2; FUT8; NCKIPSD; REPS1
Function calcium ion binding
Related Protein CAPNS1A; EFEMP2B; C1S; PLCB4; S100A7A; EFEMP2; MYL12.1; HPGDS; ITIH1; PPP3R1B
Function ephrin receptor binding
Related Protein EFNB2A; EFNA5B; EFNA1B; EFNA1A; EFNB3B; Anks1; PIK3CG; CRK; EFNA4; EPHA4
Function ligase activity
Related Protein RNF25; MARCH5L; TTLL13; MARCH3; ACSF2; PIAS4; MYLIPA; WWP1; RNF40; UBE2F
Function phosphotyrosine binding
Related Protein MAPK1; SHC1; LDLRAP1; ZAP70; CBLB; ACP2; STAP1; CBL; GRB2; CBLC
Function protein binding
Related Protein ARHGEF4; NR4A2; CRKL; CD79B; NAT2; RAB5C; TCEB2; ACP1; CDX1; MAP4
Function signal transducer activity
Related Protein GNA15.1; TAAR14E; GNA13B; EDNRBA; GNG13A; EMR4; PPFIA1; TAAR14J; CCR1L1; GHSRA
Function transcription factor activity, sequence-specific DNA binding
Related Protein TFDP1B; RBPJA; HOXB3A; YEATS4; ZNF71; BHLHE40; HOXB2A; TBX2A; TCF25; CTNNB1
Function ubiquitin protein ligase activity
Related Protein CDC34; HUWE1; CMTM2A; RNF19B; FBXL22; CBLL1; UBR3; TMEM189; TRIM6; RFWD2
Function ubiquitin-protein transferase activity
Related Protein HECTD3; NSMCE1; LMO7; MARCH6; FEM1A; RNF43; RNF141; IRAK1; BTR22; TRIM36
Function zinc ion binding
Related Protein CYLD; FHL2; ABLIM1B; IRGF4; DMD; WT1; UMPS; RNF126; TRIM35-7; DNMT1

Interacting Protein

CBL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBL here. Most of them are supplied by our site. Hope this information will be useful for your research of CBL.
SH3KBP1

CBL Related Articles

Cao, HJ; Zheng, LZ; et al. Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. BONE 74:58-68(2015).
Plani-Lam, JHC; Chow, TC; et al. PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 61:53-62(2015).