CBL
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Official Full Name
Cas-Br-M (murine) ecotropic retroviral transforming sequence
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Overview
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. -
Synonyms
4732447J05Rik; C CBL; Cas Br M (murine) ecotropic retroviral transforming sequence; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B lineage lymphoma proto oncogene; Casitas B-lineage lymphoma proto-oncogene; CBL 2; cbl; CBL_HUMAN; CBL2; E3 ubiquitin protein ligase CBL; E3 ubiquitin-protein ligase CBL; Oncogene CBL2; Proto oncogene c CBL; Proto-oncogene c-CBL; RGD1561386; RING finger protein 55; RNF55; Signal transduction protein CBL; OTTHUMP00000232087;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Arabidopsis Thaliana
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|SUMO
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CBL Related Articles
- CBL Related Research Area
- CBL Related Signal Pathway
CBL involved in several pathways and played different roles in them. We selected most pathways CBL participated on our site, such as ErbB signaling pathway, Ubiquitin mediated proteolysis, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | PRKCBB;SRC;ERBB3A;RPS6KB2;PRKCBA;BADB;ELK1;ABL2;GRB2B |
| Ubiquitin mediated proteolysis | UBE2R2;UBE2Z;SAE1;HERC2;ANAPC11;UBA2;RCHY1;UBE2E3;PARK2 |
| Endocytosis | ARPC5LA;CHMP7;D6WSU116E;VPS35;DNM2A;ARPC1A;CXCR2;RAB5C;HLA-F |
| T cell receptor signaling pathway | ZAP70;VAV2;PPP3CC;PIK3CD;CD247;SLA1;PIK3R1;GRAPA;CD28 |
| Insulin signaling pathway | PRKAG3;RAPGEF1;G6PCA.2;MKNK1;RPS6KB2;RAF1;PRKACBB;PPP1R3DA;CALM1B |
| Bacterial invasion of epithelial cells | CTTN;CBLC;RAC1;PIK3CD;DNM2;SEPT2;CRKL;ARPC2;GAB1 |
| Pathways in cancer | FGF19;TGFB3;RB1;FGF3;AGTR1B;DAPK2;FZD8;BIRC8;FGF6 |
| Proteoglycans in cancer | WNT10B;WNT2B;CDC42;ACTG1;PDPK1;FZD5;ELK1;WNT2;MDM2 |
| Chronic myeloid leukemia | BCR;PIK3R1;STAT5A;RUNX1;RB1;SOS1;MAPK3;CTBP1;MAP2K1 |
CBL has several biochemical functions, for example, SH3 domain binding, calcium ion binding, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBL itself. We selected most functions CBL had, and list some proteins which have the same functions with CBL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | DPYSL3;SHANK2;CYBA;FUT8;ARHGAP6;PARK2;CD3E;LANCL1;MICAL1 |
| calcium ion binding | PLCD4;CPS1;PADI6;S100A14;SPNA2;CAPN12;VCAN;CAPN2B;PLCZ1 |
| ephrin receptor binding | CRK;EFNB2;EFNA3B;EFNA2;NTRK3;PTPN1;CHN1;EFNB3B;EFNA1 |
| ligase activity | UBE2IA;HERC6;LIG4;TRIM22;PELI2;TRIM6;TRIM68;TRIM63;HECTD1 |
| phosphotyrosine binding | ACP2;MAPK1;FGR;SAMSN1;MAPK3;ZAP70;SHC1;CBL;GRB2 |
| protein binding | Il4ra;MUTYH;SMAD9;FER;TRIP10;B2M;IL18R1;DDX41;AKR1A1 |
| signal transducer activity | GMFB;ITGB3BP;GNA15.1;RHOL;TRIM13;RASGRP3;GNG12;GAB1;PKP1 |
| transcription factor activity, sequence-specific DNA binding | MYCL1;SREBF1;TSC22D3;ESR2;NME2;ZNF549;IRF6;FOXQ1B;SNAPC4 |
| ubiquitin protein ligase activity | UBE2B;HERC4;RNF14;RNF19A;BTRC;RNF144B;UBE2W;RNF24;RNF149 |
| ubiquitin-protein transferase activity | TRIM21;FBXO30B;MUL1B;WDSUB1;UBE2W;UBE2E1;HACE1;ZNF738;FBXL7 |
| zinc ion binding | TRIM39;ESRRGB;ZDHHC15A;TRIM65;CPB1;NR4A1;MMP7;MORC3;MARCH5 |
CBL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBL here. Most of them are supplied by our site. Hope this information will be useful for your research of CBL.
SH3KBP1
- Q&As
- Reviews
Q&As (4)
Ask a questionThere are three subtypes of CBL, which are respectively C-CBL, CBL-b and CBL-3.
CBL negatively regulates tyrosine kinase activity in tumor cells and is involved in tumor invasion.
CBL proteins function as ligands and E3 ubiquitin ligases, targeting and degrading a range of proteins.
CBL consists of a tyrosine kinase binding region at the N-terminus, a ring finger region, a proline-rich motif, threonine and tyrosine phosphorylation sites, and a C-terminus with ubiquitin ligase activity.
Customer Reviews (3)
Write a reviewPrompt delivery helped me get satisfactory experimental results in a short period of time.
The CBL proteins purchased from your company is suitable for WB.
The high quality of the purchased protein helped me to obtain satisfactory experimental results.
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