Recombinant Human CBL Protein, GST-Tagged

• Cat.No.: CBL-0457H
• Product Overview: Human CBL full-length ORF (NP_005179.2, 1 a.a. - 906 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 126 kDa
• AA Sequence: MAGNVKKSSGAGGGSGSGGSGSGGL IGLMKDAFQPHHHHHHHLSPHPPGT VDKKMVEKCWKLMDKVVRLCQNPKL ALKNSPPYILDLLPDTYQHLRTILS RYEGKMETLGENEYFRVFMENLMKK TKQTISLFKEGKERMYEENSQPRRN LTKLSLIFSHMLAELKGIFPSGLFQ GDTFRITKADAAEFWRKAFGEKTIV PWKSFRQALHEVHPISSGLEAMALK STIDLTCNDYISVFEFDIFTRLFQP WSSLLRNWNSLAVTHPGYMAFLTYD EVKARLQKFIHKPGSYIFRLSCTRL GQWAIGYVTADGNILQTIPHNKPLF QALIDGFREGFYLFPDGRNQNPDLT GLCEPTPQDHIKVTQEQYELYCEMG STFQLCKICAENDKDVKIEPCGHLM CTSCLTSWQESEGQGCPFCRCEIKG TEPIVVDPFDPRGSGSLLRQGAEGA PSPNYDDDDDERADDTLFMMKELAG AKVERPPSPFSMAPQASLPPVPPRL DLLPQRVCVPSSASALGTASKAASG SLHKDKPLPVPPTLRDLPPPPPPDR PYSVGAESRPQRRPLPCTPGDCPSR DKLPPVPSSRLGDSWLPRPIPKVPV SAPSSSDPWTGRELTNRHSLPFSLP SQMEPRPDVPRLGSTFSLDTSMSMN SSPLVGPECDHPKIKPSSSANAIYS LAARPLPVPKLPPGEQCEGEEDTEY MTPSSRPLRPLDTSQSSRACDCDQQ IDSCTYEAMYNIQSQAPSITESSTF GEGNLAAAHANTGPEESENEDDGYD VPKPPVPAVLARRTLSDISNASSSF GWLSLDGDPTTNVTEGSQVPERPPK PFPRRINSERKAGSCQQGSGPAASA ATASPQLSSEIENLMSQGYSYQDIQ KALVIAQNNIEMAKNILREFVSISS PAHVAT
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CBL Cbl proto-oncogene, E3 ubiquitin protein ligase [ Homo sapiens ]
• Official Symbol: CBL
• Synonyms: CBL; Cbl proto-oncogene, E3 ubiquitin protein ligase; Cas Br M (murine) ecotropic retroviral transforming sequence, CBL2; E3 ubiquitin-protein ligase CBL; c Cbl; oncogene CBL2; RNF55; proto-oncogene c-Cbl; RING finger protein 55; signal transduction protein CBL; casitas B-lineage lymphoma proto-oncogene; Cas-Br-M (murine) ecotropic retroviral transforming sequence; CBL2; NSLL; C-CBL
• Gene ID: 867
• mRNA Refseq: NM_005188
• Protein Refseq: NP_005179
• MIM: 165360
• UniProt ID: P22681