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CCL19

  • Official Full Name

    Chemokine (C-C motif) ligand 19

  • Overview

    Studies have shown that MIP-3B may play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. In addition, this protein may play an important role in trafficking of T- cells in thymus, and T-cell and B cell migration to secondary lymphoid organs. MIP-3B specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. MIP-3B is expressed at high levels in the lymph nodes, thymus and appendix, intermediate levels in colon and trachea, and low levels in spleen, small intestine, lung, kidney and stomach. This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. MIP-3B specifically binds to chemokine receptor CCR7.
  • Synonyms

    CCL19; RP11-195F19.11-003; CKb11; ELC; MIP-3b; MIP3B; SCYA19; C-C motif chemokine 19; CC chemokine ligand 19; CK beta-11; EBI1 ligand chemokine; EBI1-ligand chemokine; beta chemokine exodus-3; beta-chemokine exodus-3; epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; small inducible cytokine subfamily A (Cys-Cys), member 19; small-inducible cytokine A19;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Chicken
  • Cynomolgus Monkey
  • Dog
  • Horse
  • Human
  • Monkey
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Swine
  • CHO
  • E.coli
  • HEK293
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cells
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Biotin
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCL19-163H Active Recombinant Human Chemokine (C-C motif) Ligand 19, HIgG1 Fc-tagged CHO Fc
Human CCL19-298H Active Recombinant Human Chemokine (C-C Motif) Ligand 19 E.coli N/A
Human CCL19-110H Active Human CCL19 N/A
Human CCL19-162H Active Recombinant Human Chemokine (C-C motif) Ligand 19, HIgG1 Fc-tagged, mutant CHO Fc
Human CCL19-161H Active Recombinant Human Chemokine (C-C motif) Ligand 19, MIgG2a Fc-tagged CHO Fc
Human CCL19-721H Recombinant Human CCL19 protein, His-tagged E.coli His Gly22~Ser98 (Accession # Q99731)
Human CCL19-27646TH Recombinant Human CCL19, T7-tagged E.coli T7 77 amino acids
Human CCL19-154H Recombinant Human Chemokine (C-C motif) Ligand 19, T7-tagged E.coli T7
Human CCL19-583H Recombinant Human CCL19 HEK293 N/A Gly22-Ser98
Human CCL19-0618H Recombinant Human CCL19 Protein, GST-Tagged Wheat Germ GST
Human CCL19-7729HCL Recombinant Human CCL19 293 Cell Lysate HEK293 N/A
Human CCL19-60H Recombinant Human CCL19 Protein, Biotin-tagged E.coli Biotin
Human CCL19-2891H Recombinant Human CCL19 Protein E.coli N/A
Human CCL19-151H Recombinant Human CCL19 Protein, His-tagged Human Cells His
Human CCL19-4753H Recombinant Human CCL19 protein, GST-tagged E.coli GST 22-98aa
Human CCL19-3421H Recombinant Human CCL19 Protein (Gly22-Ser98), His tagged E.coli His Gly22-Ser98
Human CCL19-2936HF Recombinant Full Length Human CCL19 Protein, GST-tagged In Vitro Cell Free System GST 98 amino acids
Human CCL19-46H Recombinant Human CCL19 Protein E.coli 77 amino acid
Human CCL19-12H Active Recombinant Human CCL19 Protein E.coli
Human CCL19-013H Recombinant Human CCL19 Protein 98
Human CCL19-014H Recombinant Human CCL19 Protein, Biotinylated 98
Mouse Ccl19-623M Recombinant Mouse Ccl19 protein E.coli N/A 83
Mouse Ccl19-0620M Active Recombinant Mouse Ccl19 Protein E.coli N/A
Mouse CCL19-2962M Recombinant Mouse CCL19 Protein Mammalian Cell His
Mouse Ccl19-722M Recombinant Mouse Ccl19 protein, His-tagged E.coli His Pro22~Val107
Mouse CCL19-792M Recombinant Mouse CCL19 Protein, His-tagged Insect Cells His Met1-Ser108
Mouse Ccl19-2029M Active Recombinant Mouse Ccl19 Protein HEK293 Gly26-Val107-Leu-Glu
Mouse Ccl19-4339M Recombinant Mouse Ccl19 Protein Yeast N/A 83aa
Mouse Ccl19-022C Active Recombinant Mouse Ccl19 Protein (83 aa) E.coli 83
Mouse Ccl19-13M Active Recombinant Mouse CCL19 Protein E.coli
Mouse CCL19-2893M Recombinant Mouse CCL19 Protein HEK293 N/A
Mouse CCL19-1391M Recombinant Mouse CCL19 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CCL19-1391M-B Recombinant Mouse CCL19 Protein Pre-coupled Magnetic Beads HEK293
Rat Ccl19-682R Recombinant Rat Ccl19 E.coli N/A
Rat Ccl19-723R Recombinant Rat Ccl19 protein, His-tagged E.coli His Asp32~Lys103 (Accession # D3ZI84)
Rat Ccl19-6379R-B Recombinant Rat Ccl19 Protein Pre-coupled Magnetic Beads HEK293
Rat Ccl19-6379R Recombinant Rat Ccl19 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Monkey CCL19-4399M Recombinant Monkey CCL19 Protein Yeast N/A 77aa
Rabbit CCL19-4360R Recombinant Rabbit CCL19 Protein Yeast N/A 77aa
Dog CCL19-720D Recombinant Dog CCL19 protein, His & GST-tagged E.coli His/GST Gly24~Ser100 (Accession# Q68AY7)
Canine CCL19-4365C Recombinant Canine CCL19 Protein Yeast N/A 77aa
Cynomolgus Monkey CCL19-371C Recombinant Cynomolgus CCL19 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CCL19-119C Recombinant Cynomolgus Monkey CCL19 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CCL19-119C-B Recombinant Cynomolgus Monkey CCL19 Protein Pre-coupled Magnetic Beads HEK293
Horse CCL19-1112H Recombinant Horse CCL19 Protein, His-tagged E.coli N-His Gly24-Ser100
Rhesus Macaque CCL19-682R Recombinant Rhesus monkey CCL19 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCL19-510R Recombinant Rhesus Macaque CCL19 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CCL19-510R-B Recombinant Rhesus Macaque CCL19 Protein Pre-coupled Magnetic Beads HEK293
Swine CCL19-4359S Recombinant Swine CCL19 Protein Yeast N/A 77aa
Chicken CCL19-5640C Recombinant Chicken CCL19 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CCL19 Related Articles
  • CCL19 Related Gene Family
  • CCL19 Related Research Area

CCL19 involved in several pathways and played different roles in them. We selected most pathways CCL19 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCXCL9;TNFRSF13C;IL11RA;CCL2;GM2506;PDGFC;CCR3;CSF2;Ifna11
Chemokine signaling pathwayPRKACA;PLCB3;PRKCZ;CXCR4;CCR1;CCL22;ARRB1;CCL3L1;NRAS
NF-kappa B signaling pathwayTNFRSF11A;PTGS2;RIPK1;BIRC2;LCK;TRAF5;TNFSF14;TNFRSF1A;LTA

CCL19 has several biochemical functions, for example, CCR chemokine receptor binding, CCR10 chemokine receptor binding, CCR7 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL19 itself. We selected most functions CCL19 had, and list some proteins which have the same functions with CCL19. You can find most of the proteins on our site.

Function Related Protein
CCR chemokine receptor bindingCCL20;CCRL2;CCL19A.1;CCL19A.2;CCL35.1;CCL38A.4;CCL38A.5;CCL19B;CCL19
CCR10 chemokine receptor bindingCCL25;CXCL13;CCL19
CCR7 chemokine receptor bindingCCL21;CCL19
chemokine activityCCL34A.4;CCL25B;CCL20;CCL16;CXCL11;CCL24;CXCL14;CCL3L1;CXCL12B
chemokine receptor bindingXCL1;Ccl21c;CCL25;CCL21B;Ccl21a;S100A14;CCRL2;CCL21;CCL19

CCL19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL19 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL19.

Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).
Carubbi, F; Alunno, A; et al. Is minor salivary gland biopsy more than a diagnostic tool in primary Sjogren's syndrome? Association between clinical, histopathological, and molecular features: A retrospective study. SEMINARS IN ARTHRITIS AND RHEUMATISM 44:314-324(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What are the limitations of research on CCL19? 10/20/2022

There are still some limitations in the current research on CCL19, such as the lack of in-depth research on its specific mechanism of action and function, and the incomplete understanding of its relationship with diseases. In addition, since CCL19 is a multifunctional protein, regulating it may also have some side effects.

Why is CCL19 related to other chemokines or proteins? 05/29/2022

It has a complex relationship with other chemokines or proteins. For example, it binds to the CCR7 receptor, which directs the migration of immune cells. In addition, CCL19 interacts with other chemokines and cytokines to jointly regulate immune responses.

What are the treatment strategies for CCL19? 05/04/2022

Therapeutic strategies for CCL19 include inhibition of its expression, modulation of its activity, or use of gene therapy. For example, some studies have shown that the use of small molecule inhibitors or antibodies against CCL19 can inhibit its activity and thus treat some CCL19-related diseases. In addition, related diseases can also be treated by regulating the expression level of CCL19.

How can we better understand the role of CCL19 in disease? 02/20/2022

In order to better understand the role of CCL19 in disease, further in-depth study of its specific mechanism of action and function is needed. In addition, it is also necessary to study the changes in its expression level and activity in different diseases, as well as its relationship with the occurrence and development of diseases. At the same time, it is also necessary to explore the clinical application prospects and effects of the therapeutic strategies that regulate them. This will contribute to the development of more effective treatments to improve outcomes and quality of life for patients with CCL19-related diseases.

What is the role of CCL19 in the immune system? 12/19/2021

CCL19 is mainly involved in the recruitment and activation of immune cells. It is able to exert immune defense by binding to receptors on the cell surface to direct immune cells to migrate to the site of inflammation or infection. In addition, CCL19 is also able to regulate the activation and differentiation of immune cells, affecting the type and intensity of immune responses.

Are there new mechanisms of action or functions in recent studies of CCL19? 10/13/2020

Recent studies have found that CCL19 is also involved in the production and maintenance of lymphatic vessels. These processes have an important impact on the migration of immune cells and the regulation of immune responses, and also provide new ideas for the treatment of some diseases related to CCL19.

Customer Reviews (3)

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Reviews
03/29/2021

    The quality of the production is stable, and the batch-to-batch and intra-batch repeatability is good.

    11/10/2020

      CCL19 has a complete range of specifications and is suitable for experiments of different scales.

      03/09/2020

        The preparation is simple and we can do it ourselves.

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