CCL19 Protein


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Official Full Name Chemokine (C-C motif) ligand 19
Background Studies have shown that MIP-3B may play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. In addition, this protein may play an important role in trafficking of T- cells in thymus, and T-cell and B cell migration to secondary lymphoid organs. MIP-3B specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. MIP-3B is expressed at high levels in the lymph nodes, thymus and appendix, intermediate levels in colon and trachea, and low levels in spleen, small intestine, lung, kidney and stomach. This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. MIP-3B specifically binds to chemokine receptor CCR7.
Synonyms CCL19; RP11-195F19.11-003; CKb11; ELC; MIP-3b; MIP3B; SCYA19; C-C motif chemokine 19; CC chemokine ligand 19; CK beta-11; EBI1 ligand chemokine; EBI1-ligand chemokine; beta chemokine exodus-3; beta-chemokine exodus-3; epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; small inducible cytokine subfamily A (Cys-Cys), member 19; small-inducible cytokine A19
    • Species :
    • Canine
    • Chicken
    • Cynomolgus Monkey
    • Dog
    • Horse
    • Human
    • Monkey
    • Mouse
    • Rabbit
    • Rat
    • Swine
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cells
    • In Vitro Cell Free System
    • Insect Cells
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • Biotin
    • Fc
    • GST
    • His
    • N/A
    • N-His
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCL19-721H Recombinant Human CCL19 protein, His-tagged E.coli His
    Human CCL19-0618H Recombinant Human CCL19 Protein, GST-Tagged Wheat Germ GST
    Human CCL19-110H Human CCL19 N/A
    Human CCL19-154H Recombinant Human Chemokine (C-C motif) Ligand 19, T7-tagged E.coli T7
    Human CCL19-161H Recombinant Human Chemokine (C-C motif) Ligand 19, MIgG2a Fc-tagged CHO Fc
    Human CCL19-162H Recombinant Human Chemokine (C-C motif) Ligand 19, HIgG1 Fc-tagged, mutant CHO Fc
    Human CCL19-163H Recombinant Human Chemokine (C-C motif) Ligand 19, HIgG1 Fc-tagged CHO Fc
    Human CCL19-27646TH Recombinant Human CCL19, T7-tagged E.coli T7
    Human CCL19-298H Recombinant Human Chemokine (C-C Motif) Ligand 19 E.coli N/A
    Human CCL19-583H Recombinant Human CCL19 HEK293 N/A
    Mouse Ccl19-0620M Recombinant Mouse Ccl19 Protein E.coli N/A
    Mouse CCL19-2962M Recombinant Mouse CCL19 Protein Mammalian Cell His
    Mouse Ccl19-623M Recombinant Mouse Ccl19 protein E.coli N/A
    Mouse Ccl19-722M Recombinant Mouse Ccl19 protein, His-tagged E.coli His
    Rat Ccl19-682R Recombinant Rat Ccl19 E.coli N/A
    Rat Ccl19-723R Recombinant Rat Ccl19 protein, His-tagged E.coli His
    Cynomolgus Monkey CCL19-371C Recombinant Cynomolgus CCL19 Protein, His-tagged Mammalian Cell His
    Dog CCL19-720D Recombinant Dog CCL19 protein, His & GST-tagged E.coli His/GST
    Chicken CCL19-5640C Recombinant Chicken CCL19 Mammalian Cell His
    Human CCL19-7729HCL Recombinant Human CCL19 293 Cell Lysate HEK293 N/A
    Horse CCL19-1112H Recombinant Horse CCL19 Protein, His-tagged E.coli N-His
    Human CCL19-151H Recombinant Human CCL19 Protein, His-tagged Human Cells His
    Human CCL19-2936HF Recombinant Full Length Human CCL19 Protein, GST-tagged In Vitro Cell Free System GST
    Human CCL19-46H Recombinant Human CCL19 Protein E.coli
    Human CCL19-4753H Recombinant Human CCL19 protein, GST-tagged E.coli GST
    Human CCL19-60H Recombinant Human CCL19 Protein, Biotin-tagged E.coli Biotin
    Human CCL19-2891H Recombinant Human CCL19 Protein E.coli N/A
    Mouse Ccl19-2029M Recombinant Mouse Ccl19 Protein HEK293
    Mouse CCL19-2893M Recombinant Mouse CCL19 Protein HEK293 N/A
    Mouse Ccl19-4339M Recombinant Mouse Ccl19 Protein Yeast N/A
    Mouse CCL19-792M Recombinant Mouse CCL19 Protein, His-tagged Insect Cells His
    Canine CCL19-4365C Recombinant Canine CCL19 Protein Yeast N/A
    Rabbit CCL19-4360R Recombinant Rabbit CCL19 Protein Yeast N/A
    Swine CCL19-4359S Recombinant Swine CCL19 Protein Yeast N/A
    Monkey CCL19-4399M Recombinant Monkey CCL19 Protein Yeast N/A

    CCL19 involved in several pathways and played different roles in them. We selected most pathways CCL19 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction TGFB3; LEPA; IL20RB; ACVR2AA; IL10; IL9; FAS; CXCR4; BMPR1AB; VEGFB
    Chemokine signaling pathway GNG3; SHC2; CCR7; SOS1; GRK7; GNB2; XCL1; CCR3; PRKCD; RAC2
    NF-kappa B signaling pathway IKBKB; TLR4; IRAK1; TAB2; TRAF6; VCAM1; RIPK1; ERC1; RELA; BTK

    CCL19 has several biochemical functions, for example, CCR chemokine receptor binding, CCR10 chemokine receptor binding, CCR7 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL19 itself. We selected most functions CCL19 had, and list some proteins which have the same functions with CCL19. You can find most of the proteins on our site.

    Function Related Protein
    CCR chemokine receptor binding CCL33.3; CCL26; CCL38A.4; XCL2; CCL15; CCRL2; CCL13; CCL22; CCL17; CCL19
    CCR10 chemokine receptor binding CXCL13; CCL19; CCL25
    CCR7 chemokine receptor binding CCL21; CCL19
    chemokine activity IL-8; CXCL32B.1; CCL26; CCL21; CCL34A.3; CCL33.2; CCL20; CXL34B.11; CXCL9; CCL1
    chemokine receptor binding XCL1; CCL19; CCRL2; CCL25; CCL21; CXCL12; CCL21B; Ccl21a; Ccl21c; S100A14

    CCL19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL19 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL19.

    Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).
    Carubbi, F; Alunno, A; et al. Is minor salivary gland biopsy more than a diagnostic tool in primary Sjogren's syndrome? Association between clinical, histopathological, and molecular features: A retrospective study. SEMINARS IN ARTHRITIS AND RHEUMATISM 44:314-324(2014).

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