CCR4

  • Official Full Name

    chemokine (C-C motif) receptor 4

  • Overview

    High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
  • Synonyms

    CCR4; chemokine (C-C motif) receptor 4; LESTR; Sdf1r; CHEMR1; Cmkbr4; C-C CKR-4; C-C chemokine receptor type 4; fusin; chemokine (C-C) receptor 4; leukocyte-expressed seven-transmembrane-domain receptor;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • in vitro E. coli
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • Flag
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCR4-49624H Active Recombinant Human CCR4 Full Length Transmembrane protein(VLPs) HEK293 N/A
Human CCR4-273H Active Recombinant Human CCR4 Full Length Transmembrane protein (1-360 aa), His-tagged(VLPs) HEK293 His 1-360aa
Human CCR4-294H Active Recombinant Human CCR4 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CCR4-49623H Active Recombinant Human CCR4 Full Length Transmembrane protein(MNP) HEK293 N/A
Human CCR4-0692H Recombinant Human CCR4 Protein Wheat Germ N/A
Human CCR4-5882H Recombinant Human CCR4 protein, His-SUMO-tagged E.coli His-SUMO 309-360aa
Human CCR4-938H Recombinant Human CCR4 protein, His-tagged E.coli His 1-360aa
Human CCR4-274H Active Recombinant Human CCR4 Full Length Transmembrane protein (1-360 aa), His-tagged In vitro E. coli expression system His 1-360aa
Human CCR4-2724H Recombinant Human CCR4 Protein (1-360 aa), His-tagged in vitro E. coli His 1-360 aa
Human CCR4-1074HFL Recombinant Human CCR4 protein, His&Flag-tagged HEK293 His&Flag 1-360 aa
Human CCR4-3008HF Recombinant Full Length Human CCR4 Protein In Vitro Cell Free System 360 amino acids
Canis lupus familiaris (Dog) (Canis familiaris) RFL12204CF Recombinant Full Length Dog C-C Chemokine Receptor Type 4(Ccr4) Protein, His-Tagged E.coli expression system His Full Length (1-360)
Homo sapiens (Human) RFL36250HF Recombinant Full Length Human C-C Chemokine Receptor Type 4(Ccr4) (Active) Protein, His-Tagged E.coli expression system His Full Length (1-360aa)
Homo sapiens (Human) RFL11104HF Recombinant Full Length Human C-C Chemokine Receptor Type 4(Ccr4)-Vlps (Active) Protein, His-Tagged E.coli expression system His Full Length (1-360aa)
Mus musculus (Mouse) RFL27589MF Recombinant Full Length Mouse C-C Chemokine Receptor Type 4(Ccr4) Protein, His-Tagged E.coli expression system His Full Length (1-360)
Rhesus Macaque CCR4-707R Recombinant Rhesus monkey CCR4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCR4-534R Recombinant Rhesus Macaque CCR4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CCR4-534R-B Recombinant Rhesus Macaque CCR4 Protein Pre-coupled Magnetic Beads HEK293
Kit-0872 D-Lactate Assay Kit N/A
Kit-1152 CCR4 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1151 CCR4 Total GPCR Internalization Assay Kit N/A
  • Other Resource

CCR4 involved in several pathways and played different roles in them. We selected most pathways CCR4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CCR4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CCR4 itself. We selected most functions CCR4 had, and list some proteins which have the same functions with CCR4. You can find most of the proteins on our site.

Function Related Protein

CCR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR4.

Gene Family

Chemokines Cytokines

Research Area

Related articles

Yamauchi, J; Coler-Reilly, A; et al. Mogamulizumab, an Anti-CCR4 Antibody, Targets Human T-Lymphotropic Virus Type 1-infected CD8(+) and CD4(+) T Cells to Treat Associated Myelopathy. JOURNAL OF INFECTIOUS DISEASES 211:238-248(2015).
Ni, X; Jorgensen, JL; et al. Reduction of Regulatory T Cells by Mogamulizumab, a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients with Aggressive/Refractory Mycosis Fungoides and Sezary Syndrome. CLINICAL CANCER RESEARCH 21:274-285(2015).
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